Molecular Cell, Год журнала: 2023, Номер 84(1), С. 34 - 54
Опубликована: Ноя. 13, 2023
Язык: Английский
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Июль 22, 2022
Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-apoptotic and anti-inflammatory properties, plays an important role in treatment of aging-related diseases. Sirtuin 1 (SIRT1), member NAD+-dependent deacetylase enzyme family, is extensively explored as potential therapeutic target for attenuating aging-induced disorders. SIRT1 possess beneficial effects against diseases such Alzheimer's disease (AD), Parkinson's (PD), Huntington's (HD), Depression, Osteoporosis, Myocardial ischemia (M/I) reperfusion (MI/R), Atherosclerosis (AS), Diabetes. Previous studies have reported that aging increases tissue susceptibility, whereas, regulates cellular senescence multiple processes, including SIRT1/Keap1/Nrf2/HO-1 SIRTI/PI3K/Akt/GSK-3β mediated oxidative stress, SIRT1/NF-κB SIRT1/NLRP3 regulated inflammatory response, SIRT1/PGC1α/eIF2α/ATF4/CHOP SIRT1/PKD1/CREB controlled phosphorylation, SIRT1-PINK1-Parkin mitochondrial damage, SIRT1/FoxO autophagy, SIRT1/FoxG1/CREB/BDNF/Trkβ-catenin neuroprotective effects. In this review, we summarized improvement attenuation effect quercetin on relationship between relevant signaling pathways by SIRT1. Moreover, functional regulation markers function, autophagy apoptosis through was discussed. Finally, prospects extracellular vesicles (EVs) loading delivery, SIRT1-mediated EVs signal carriers treating diseases, well discussed ferroptosis alleviation to protect via activating Generally, may serve promising inhibiting reducing responses, restoring dysfunction.
Язык: Английский
Процитировано
204
Science China Life Sciences, Год журнала: 2023, Номер 66(5), С. 893 - 1066
Опубликована: Апрель 11, 2023
Язык: Английский
Процитировано
194
Nature reviews. Immunology, Год журнала: 2022, Номер 23(2), С. 75 - 89
Опубликована: Июль 13, 2022
Язык: Английский
Процитировано
184
Nature Communications, Год журнала: 2020, Номер 11(1)
Опубликована: Ноя. 5, 2020
Abstract Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to dysfunction of marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) an essential intermediate tricarboxylic acid (TCA) cycle. Studies have revealed that αKG extends lifespan worms maintains pluripotency embryonic stem (ESCs). Here, we show administration increases mass aged mice, attenuates age-related loss, accelerates regeneration rodents. ameliorates senescence-associated (SA) phenotypes MSCs derived from as well promoting their proliferation, colony formation, migration, osteogenic potential. Mechanistically, decreases accumulations H3K9me3 H3K27me3, subsequently upregulates BMP signaling Nanog expression. Collectively, our findings illuminate role rejuvenating ameliorating osteoporosis, with a promising therapeutic potential diseases.
Язык: Английский
Процитировано
173
Nature Reviews Genetics, Год журнала: 2022, Номер 23(10), С. 585 - 605
Опубликована: Май 2, 2022
Язык: Английский
Процитировано
168
International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(1), С. 401 - 401
Опубликована: Янв. 2, 2021
Aging represents the multifactorial decline in physiological function of every living organism. Over past decades, several hallmarks aging have been defined, including epigenetic deregulation. Indeed, multiple events were found altered across different species during aging. Epigenetic changes directly contributing to and aging-related diseases include accumulation histone variants, chromatin accessibility, loss histones heterochromatin, aberrant modifications, deregulated expression/activity miRNAs. As a consequence, cellular processes are affected, which results development or progression human pathologies, cancer, diabetes, osteoporosis, neurodegenerative disorders. In this review, we focus on mechanisms underlying various describe how these deregulations contribute diseases.
Язык: Английский
Процитировано
166
Nature Aging, Год журнала: 2022, Номер 2(3), С. 243 - 253
Опубликована: Март 7, 2022
Язык: Английский
Процитировано
160
Ageing Research Reviews, Год журнала: 2022, Номер 81, С. 101743 - 101743
Опубликована: Окт. 4, 2022
Язык: Английский
Процитировано
140
Nature, Год журнала: 2022, Номер 607(7918), С. 249 - 255
Опубликована: Июль 13, 2022
Язык: Английский
Процитировано
120
Nucleic Acids Research, Год журнала: 2021, Номер 49(8), С. 4203 - 4219
Опубликована: Март 1, 2021
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging aging-related diseases. However, the role SIRT3 in regulating human stem cell homeostasis remains unclear. Here we found that expression was downregulated senescent mesenchymal cells (hMSCs). CRISPR/Cas9-mediated depletion led compromised nuclear integrity, loss heterochromatin accelerated senescence hMSCs. Further analysis indicated interacted with envelope proteins heterochromatin-associated proteins. deficiency resulted detachment genomic lamina-associated domains (LADs) from lamina, increased chromatin accessibility aberrant repetitive sequence transcription. The re-introduction rescued disorganized phenotypes. Taken together, our study reveals novel for stabilizing counteracting hMSC senescence, providing new potential therapeutic targets ameliorate
Язык: Английский
Процитировано
115