Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 9, 2024
Abstract
Radiotherapy-induced
immune
activation
holds
great
promise
for
optimizing
cancer
treatment
efficacy.
Here,
we
describe
a
clinically
used
radiosensitizer
hafnium
oxide
(HfO
2
)
that
was
core
coated
with
MnO
shell
followed
by
glucose
oxidase
(GOx)
doping
nanoplatform
@MnO
@GOx,
HMG)
to
trigger
ferroptosis
adjuvant
effects
glutathione
depletion
and
reactive
oxygen
species
production.
This
cascade
potentiation
further
sensitized
radiotherapy
enhancing
DNA
damage
in
4T1
breast
tumor
cells.
The
combination
of
HMG
nanoparticles
effectively
activated
the
damaged
Mn
2+
-mediated
cGAS-STING
pathway
vitro
vivo.
process
had
significant
inhibitory
on
progression
initiating
an
anticancer
systemic
response
prevent
distant
recurrence
achieve
long-lasting
suppression
both
primary
tumors.
Furthermore,
as-prepared
“turned
on”
spectral
computed
tomography
(CT)/magnetic
resonance
dual-modality
imaging
signals,
demonstrated
favorable
contrast
enhancement
capabilities
under
GSH
microenvironment.
result
highlighted
potential
as
theranostic
achieving
molecular
guided
sensitization
induced
synergistic
immunotherapy.
Molecular Metabolism,
Год журнала:
2023,
Номер
74, С. 101755 - 101755
Опубликована: Июнь 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 24, 2024
Abstract
Aging
is
a
complex
and
multifaceted
process
involving
variety
of
interrelated
molecular
mechanisms
cellular
systems.
Phenotypically,
the
biological
aging
accompanied
by
gradual
loss
function
systemic
deterioration
multiple
tissues,
resulting
in
susceptibility
to
aging-related
diseases.
Emerging
evidence
suggests
that
closely
associated
with
telomere
attrition,
DNA
damage,
mitochondrial
dysfunction,
nicotinamide
adenine
dinucleotide
levels,
impaired
macro-autophagy,
stem
cell
exhaustion,
inflammation,
protein
balance,
deregulated
nutrient
sensing,
altered
intercellular
communication,
dysbiosis.
These
age-related
changes
may
be
alleviated
intervention
strategies,
such
as
calorie
restriction,
improved
sleep
quality,
enhanced
physical
activity,
targeted
longevity
genes.
In
this
review,
we
summarise
key
historical
progress
exploration
important
causes
anti-aging
strategies
recent
decades,
which
provides
basis
for
further
understanding
reversibility
phenotypes,
application
prospect
synthetic
biotechnology
therapy
also
prospected.
Aging and Disease,
Год журнала:
2024,
Номер
15(2), С. 546 - 546
Опубликована: Янв. 1, 2024
Aging
is
one
of
the
most
serious
risk
factors
for
glaucoma,
and
according
to
age-standardized
prevalence,
glaucoma
second
leading
cause
legal
blindness
worldwide.
Cellular
senescence
a
hallmark
aging
that
defined
by
stable
exit
from
cell
cycle
in
response
cellular
damage
stress.
The
potential
mechanisms
underlying
glaucomatous
include
oxidative
stress,
DNA
damage,
mitochondrial
dysfunction,
defective
autophagy/mitophagy,
epigenetic
modifications.
These
phenotypes
interact
generate
sufficiently
network
maintain
senescent
state.
Senescent
trabecular
meshwork
(TM)
cells,
retinal
ganglion
cells
(RGCs)
vascular
endothelial
reportedly
accumulate
with
age
stress
may
contribute
pathologies.
Therapies
targeting
suppression
or
elimination
have
been
found
ameliorate
RGC
death
improve
vision
models,
suggesting
pivotal
role
pathophysiology
glaucoma.
In
this
review,
we
explore
biological
links
between
specifically
delving
into
senescence.
Moreover,
summarize
current
data
on
key
target
associated
development
clinical
Finally,
discuss
therapeutic
management
Foods,
Год журнала:
2025,
Номер
14(3), С. 347 - 347
Опубликована: Янв. 21, 2025
Bee
pollen
is
characterized
by
an
exceptional
diversity
and
abundance
of
micronutrients
bioactive
phytochemicals.
This
richness
remains
very
sparsely
investigated,
but
accumulating
evidence
strongly
supports
a
promising
future
for
bee
in
human
nutrition
medicine.
Epigenetic
regulation
among
the
most
compelling
biomedical
topics
that
remain
completely
untapped
derivative
research.
In
our
current
research,
we
identified
numerous
ubiquitous
compounds
are
consistently
present
this
matrix,
regardless
its
botanical
geographical
origins,
have
been
well
studied
documented
as
epigenetic
regulators
recent
years.
Given
relative
newness
both
research
studies
within
nutritional,
pharmaceutical,
medical
sciences,
review
aims
to
bridge
these
valuable
fields
advance
related
experimental
investigations.
To
best
knowledge,
first
work
has
aimed
comprehensively
investigate
modulatory
potential
compounds.
Our
findings
also
unveiled
several
intriguing
phenomena,
such
dual
effect
same
compound
depending
on
cellular
context
or
some
cross-generational
heritability
traits.
Although
whole
extract
still
lacking,
study
clearly
indicates
avenue
worth
further
We
hope
constitutes
foundational
cornerstone
investigations
