Physiological Reviews,
Год журнала:
2022,
Номер
103(3), С. 2057 - 2170
Опубликована: Ноя. 17, 2022
Repeated,
episodic
bouts
of
skeletal
muscle
contraction
undertaken
frequently
as
structured
exercise
training
are
a
potent
stimulus
for
physiological
adaptation
in
many
organs.
Specifically,
muscle,
remarkable
plasticity
is
demonstrated
by
the
remodeling
structure
and
function
terms
muscular
size,
force,
endurance,
contractile
velocity
result
functional
demands
induced
various
types
training.
This
plasticity,
mechanistic
basis
adaptations
to
response
training,
underpinned
activation
and/or
repression
molecular
pathways
processes
each
individual
acute
session.
These
include
transduction
signals
arising
from
neuronal,
mechanical,
metabolic,
hormonal
stimuli
through
complex
signal
networks,
which
linked
myriad
effector
proteins
involved
regulation
pre-
posttranscriptional
processes,
protein
translation
degradation
processes.
review
therefore
describes
exercise-induced
responses
including
emerging
concepts
such
epigenetic
degradation.
A
critical
appraisal
methodological
approaches
current
state
knowledge
informs
series
recommendations
offered
future
directions
field.
Circulation Research,
Год журнала:
2021,
Номер
128(7), С. 993 - 1020
Опубликована: Апрель 1, 2021
A
link
between
oxidative
stress
and
hypertension
has
been
firmly
established
in
multiple
animal
models
of
but
remains
elusive
humans.
While
initial
studies
focused
on
inactivation
nitric
oxide
by
superoxide,
our
understanding
relevant
reactive
oxygen
species
(superoxide,
hydrogen
peroxide,
peroxynitrite)
how
they
modify
complex
signaling
pathways
to
promote
expanded
significantly.
In
this
review,
we
summarize
recent
advances
delineating
the
primary
secondary
sources
(nicotinamide
adenine
dinucleotide
phosphate
oxidases,
uncoupled
endothelial
synthase,
endoplasmic
reticulum,
mitochondria),
posttranslational
modifications
induce
protein
targets
important
for
redox
signaling,
their
interplay
with
endogenous
antioxidant
systems,
role
inflammasome
activation
reticular
development
hypertension.
We
highlight
different
organ
systems
contributes
hypertension,
describe
new
that
have
clarified
importance
specific
proteins,
discuss
clinical
shed
light
these
processes
are
altered
human
Finally,
focus
promise
proteomics
biology
help
us
fully
understand
relationship
ROS
potential
designing
evaluating
novel
antihypertensive
therapies.
