The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 374 - 403

Опубликована: Март 1, 2023

Язык: Английский

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Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Июнь 20, 2022

Abstract In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not ICIs, partly caused absence of tumor-infiltrating lymphocytes (TILs), significantly limits application ICIs. Converting these “cold” into “hot” may ICIs is an unsolved question immunotherapy. Since it a general characteristic cancers resist apoptosis, induction non-apoptotic regulated cell death (RCD) emerging as new treatment strategy. Recently, several studies have revealed interaction between RCD and antitumor immunity. Specifically, autophagy, ferroptosis, pyroptosis, necroptosis exhibit synergistic responses while possibly exerting inhibitory effects on responses. Thus, targeted therapies (inducers inhibitors) against combination with exert potent activity, resistant This review summarizes multilevel relationship immunity RCD, including necroptosis, potential targeting improve efficacy malignancy.

Язык: Английский

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Mitochondrial control of inflammation

Nature reviews. Immunology, Год журнала: 2022, Номер 23(3), С. 159 - 173

Опубликована: Июль 25, 2022

Язык: Английский

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Immunogenic Cell Death Activates the Tumor Immune Microenvironment to Boost the Immunotherapy Efficiency

Advanced Science, Год журнала: 2022, Номер 9(22)

Опубликована: Июнь 2, 2022

Abstract Tumor immunotherapy is only effective in a fraction of patients due to low response rate and severe side effects, these challenges clinics can be addressed through induction immunogenic cell death (ICD). ICD elicited from many antitumor therapies release danger associated molecular patterns (DAMPs) tumor‐associated antigens facilitate maturation dendritic cells (DCs) infiltration cytotoxic T lymphocytes (CTLs). The process reverse the tumor immunosuppressive microenvironment improve sensitivity immunotherapy. Nanostructure‐based drug delivery systems (NDDSs) are explored induce by incorporating therapeutic molecules for chemotherapy, photosensitizers (PSs) photodynamic therapy (PDT), photothermal conversion agents (PTT), radiosensitizers radiotherapy (RT). These NDDSs loaded at right dose place time, resulting greater effectiveness lower toxicity. Immunotherapeutic also combined with achieve synergic effect multi‐modality approach. In this review, harnessed load multiple PDT, PTT, RT combination promote reduce effects cancer treatment.

Язык: Английский

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Antibody–drug conjugates come of age in oncology

Nature Reviews Drug Discovery, Год журнала: 2023, Номер 22(8), С. 641 - 661

Опубликована: Июнь 12, 2023

Язык: Английский

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Pathogenesis of autoimmune disease

Nature Reviews Nephrology, Год журнала: 2023, Номер 19(8), С. 509 - 524

Опубликована: Май 10, 2023

Autoimmune diseases are a diverse group of conditions characterized by aberrant B cell and T reactivity to normal constituents the host. These occur widely affect individuals all ages, especially women. Among these diseases, most prominent immunological manifestation is production autoantibodies, which provide valuable biomarkers for diagnosis, classification disease activity. Although cells have key role in pathogenesis, they technically more difficult assay. In general, autoimmune results from an interplay between genetic predisposition environmental factors. Genetic autoimmunity complex can involve multiple genes that regulate function immune populations. Less frequently, result single-gene mutations regulatory pathways. Infection seems be common trigger disease, although microbiota also influence pathogenesis. As shown seminal studies, patients may express autoantibodies many years before appearance clinical or laboratory signs — period called pre-clinical autoimmunity. Monitoring autoantibody expression at-risk populations therefore enable early detection initiation therapy prevent attenuate tissue damage. Autoimmunity not static, however, remission achieved some treated with current agents. host constituents. This Review provides overview basis focus on given their as markers

Язык: Английский

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Meta-hallmarks of aging and cancer

Cell Metabolism, Год журнала: 2023, Номер 35(1), С. 12 - 35

Опубликована: Янв. 1, 2023

Язык: Английский

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Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity

Cancer Discovery, Год журнала: 2022, Номер 13(2), С. 410 - 431

Опубликована: Окт. 27, 2022

Abstract Cellular senescence is a stress response that activates innate immune cells, but little known about its interplay with the adaptive system. Here, we show senescent cells combine several features render them highly efficient in activating dendritic (DC) and antigen-specific CD8 T cells. This includes release of alarmins, activation IFN signaling, enhanced MHC class I machinery, presentation senescence-associated self-peptides can activate In context cancer, immunization cancer elicits strong antitumor protection mediated by DCs Interestingly, this superior to undergoing immunogenic cell death. Finally, induction human primary also augments their ability autologous tumor-infiltrating lymphocytes. Our study indicates be exploited develop protective CD8-dependent responses. Significance: shows are endowed high potential—superior gold standard We harness these properties trigger See related article Chen et al., p. 432. highlighted Issue feature, 247

Язык: Английский

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Emerging evidence for adapting radiotherapy to immunotherapy

Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(8), С. 543 - 557

Опубликована: Июнь 6, 2023

Язык: Английский

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Chronic inflammation and the hallmarks of aging

Molecular Metabolism, Год журнала: 2023, Номер 74, С. 101755 - 101755

Опубликована: Июнь 16, 2023

Recently, the hallmarks of aging were updated to include dysbiosis, disabled macroautophagy, and chronic inflammation. In particular, low-grade inflammation during aging, without overt infection, is defined as "inflammaging," which associated with increased morbidity mortality in population. Emerging evidence suggests a bidirectional cyclical relationship between development age-related conditions, such cardiovascular diseases, neurodegeneration, cancer, frailty. How crosstalk other underlies biological mechanisms disease thus particular interest current geroscience research.

Язык: Английский

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