Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(33), С. 8007 - 8032
Опубликована: Янв. 1, 2024
Inflammatory
skin
diseases,
such
as
psoriasis
and
atopic
dermatitis,
pose
significant
health
challenges
due
to
their
long-lasting
nature,
potential
for
serious
complications,
risks,
which
requires
treatments
that
are
both
effective
exhibit
minimal
side
effects.
Hydrogels
offer
an
innovative
solution
biocompatibility,
tunability,
controlled
drug
delivery
capabilities,
enhanced
treatment
adherence
minimized
effects
risk.
This
review
explores
the
mechanisms
guide
design
of
hydrogel
therapeutic
platforms
from
multiple
perspectives,
focusing
on
components
hydrogels,
adjustable
physical
chemical
properties,
interactions
with
cells
drugs
underscore
clinical
potential.
We
also
examine
various
agents
dermatitis
can
be
integrated
into
including
traditional
drugs,
novel
compounds
targeting
oxidative
stress,
small
molecule
biologics,
emerging
therapies,
offering
insights
advantages.
Additionally,
we
trial
data
evaluate
effectiveness
safety
hydrogel-based
in
managing
under
complex
disease
conditions.
Lastly,
discuss
current
future
opportunities
therapeutics
treating
improving
barrier
penetration
developing
multifunctional
highlight
enhance
long-term
stability.
Environment International,
Год журнала:
2024,
Номер
184, С. 108415 - 108415
Опубликована: Янв. 8, 2024
An
increasing
number
of
harmful
environmental
factors
are
causing
serious
impacts
on
human
health,
and
there
is
an
urgent
need
to
accurately
identify
the
toxic
effects
mechanisms
these
factors.
However,
traditional
toxicity
test
methods
(e.g.,
animal
models
cell
lines)
often
fail
provide
accurate
results.
Fortunately,
organoids
differentiated
from
stem
cells
can
more
accurately,
sensitively
specifically
reflect
body.
They
also
suitable
for
specific
studies
frequently
used
in
toxicology
nowadays.
As
a
combination
organ-on-a-chip
technology,
organoids-on-a-chip
has
great
potential
toxicology.
It
controllable
physicochemical
microenvironment
not
easy
be
contaminated.
higher
homogeneity
size
shape
organoids.
In
addition,
it
achieve
vascularization
exchange
nutrients
metabolic
wastes
time.
Multi-organoids-chip
simulate
interactions
different
organs.
These
advantages
facilitate
better
function
maturity
organoids,
which
make
up
shortcomings
common
certain
extent.
This
review
firstly
discussed
limitations
testing
platforms,
leading
introduction
new
platforms:
organoids-on-a-chip.
Next,
applications
were
summarized
prospected.
Since
platforms
have
been
sufficiently
considered
previous
literature,
we
particularly
emphasized
them.
Finally,
this
opportunities
challenges
faced
by
organoids-on-a-chip,
with
expectation
that
readers
will
gain
deeper
understanding
their
value
field
npj Biological Physics and Mechanics.,
Год журнала:
2025,
Номер
2(1)
Опубликована: Фев. 4, 2025
Abstract
The
cancer
metastatic
cascade
includes
a
series
of
mechanical
barrier-crossing
events,
involving
the
physical
movement
cells
from
their
primary
location
to
distant
organ.
This
review
describes
changes
that
influence
tumour
proliferation,
progression,
and
metastasis.
We
identify
potential
signatures
at
every
step
discuss
some
latest
mechanobiology-based
therapeutic
interventions
highlight
importance
interdisciplinary
approaches
in
diagnosis
treatment.
Cancer
stem
cells
(CSCs)
are
central
to
tumor
progression,
metastasis,
immune
evasion,
and
therapeutic
resistance.
Characterized
by
remarkable
self-renewal
adaptability,
CSCs
can
transition
dynamically
between
stem-like
differentiated
states
in
response
external
stimuli,
a
process
termed
"CSC
plasticity."
This
adaptability
underpins
their
resilience
therapies,
including
checkpoint
inhibitors
adoptive
cell
therapies
(ACT).
Beyond
intrinsic
properties,
reside
specialized
microenvironment—the
CSC
niche—which
provides
immune-privileged
protection,
sustains
stemness,
fosters
suppression.
review
highlights
the
critical
role
of
niche
driving
immunotherapy
resistance,
emphasizing
need
for
integrative
approaches
overcome
these
challenges.
The
Ilizarov
technique
has
been
continuously
innovated
to
utilize
tensile
stress
(TS)
for
inducing
a
bone
development-like
regenerative
process,
aiming
achieve
skeletal
elongation
and
reconstruction.
However,
it
remains
uncertain
whether
this
distraction
osteogenesis
(DO)
process
induced
by
TS
involves
the
pivotal
coupling
of
angiogenesis
mediated
type
H
endothelial
cells
(THECs).
In
study,
is
demonstrated
that
induces
formation
metaphysis-like
architecture
composed
THECs,
leading
segmental
regeneration
during
DO
process.
Mechanistically,
cell-matrix
interactions-mediated
activation
yes-associated
protein
(YAP)/transcriptional
co-activator
with
PDZ-binding
motif
(TAZ)
transcriptionally
upregulates
expression
Notch1
Delta-like
ligand
4,
which
act
as
direct
positive
regulators
THECs
phenotype,
in
marrow
(BMECs)
upon
stimulation.
Simultaneously,
Notch
intracellular
domain
enhances
YAP/TAZ
activity
upregulating
YAP
stabilizing
TAZ
protein,
thus
establishing
YAP/TAZ-Notch
circuit.
Additionally,
TS-stimulated
BMECs
secrete
exosomes
enriched
vital
molecules
feedback
pathway,
can
be
utilized
promote
defect
healing,
mimicking
therapeutic
effects
technique.
findings
advance
understanding
TS-induced
establish
foundation
innovative
biological
strategies
aimed
at
activating
THECs.
