Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(8), С. 8710 - 8725
Опубликована: Авг. 9, 2024
Hollow
structures
are
essential
for
development
and
physiological
activity.
The
construction
maintenance
of
hollow
never
cease
throughout
the
lives
multicellular
animals.
Epithelial
tissue
closure
is
main
strategy
used
by
living
organisms
to
build
structures.
high
diversity
simplicity
their
in
Drosophila
make
it
an
excellent
model
study
structure
morphogenesis.
In
this
review,
we
summarize
processes
that
give
rise
or
maintain
highlight
molecular
mechanisms
distinct
cell
biology
involved
these
processes.
Cell,
Год журнала:
2024,
Номер
187(14), С. 3461 - 3495
Опубликована: Июнь 20, 2024
Developmental
biology-the
study
of
the
processes
by
which
cells,
tissues,
and
organisms
develop
change
over
time-has
entered
a
new
golden
age.
After
molecular
genetics
revolution
in
80s
90s
diversification
field
early
21st
century,
we
have
phase
when
powerful
technologies
provide
approaches
open
unexplored
avenues.
Progress
has
been
accelerated
advances
genomics,
imaging,
engineering,
computational
biology
emerging
model
systems
ranging
from
tardigrades
to
organoids.
We
summarize
how
revolutionary
led
remarkable
progress
understanding
animal
development.
describe
classic
questions
gene
regulation,
pattern
formation,
morphogenesis,
organogenesis,
stem
cell
are
being
revisited.
discuss
connections
development
with
evolution,
self-organization,
metabolism,
time,
ecology.
speculate
developmental
might
evolve
an
era
synthetic
biology,
artificial
intelligence,
human
engineering.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Integrin
and
focal
adhesion
can
regulate
cytoskeleton
distribution
to
govern
actin-related
force
remodeling
play
an
important
role
in
nuclear
configuration
force-sensing
mechanotransduction
of
stem
cells.
However,
further
exploration
the
interaction
between
actinin
complex
myosin,
kinetics,
molecular
mechanism
structures
nucleate
within
engineered
cells
is
vague.
An
extensive
comprehension
cell
morphogenesis,
remodeling,
essential
reveal
basic
physical
principles
polymerization
force-related
signaling
delivery.
Advanced
microarrays
are
designed
determine
heterogeneous
morphology
behaviors
The
heterogeneity
from
transferred
into
nuclei
by
evaluation
Lamins,
YAP,
BrdU
expression.
Tuning
activation
proteins
nucleators
adjust
mechanics
may
be
underlying
change
response
its
physiological
microarrayed
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101645 - 101645
Опубликована: Март 8, 2025
Polyetheretherketone
(PEEK)
has
potential
to
repair
the
orbital
floor
bone
defects
following
craniofacial
trauma
and
surgery.
However,
inertness
of
material
impedes
soft
tissue
integration
implants,
leading
complications
such
as
implant
migration
infection.
Surface
patterning
modification
on
PEEK
can
promote
surface
hydrophily
enhance
better
integration,
but
it
is
difficult
obtain
uniform
controllable
nano-structure.
In
this
study,
hot-pressing
technology
was
used
produce
nanopores
with
a
diameter
200,
500,
800
nm.
Depending
craft,
surficial
mechanical
properties
be
regulated
assessed
by
finite
element
analysis.
Furthermore,
500
nm
interface
proliferation,
migration,
fibrosis
fibroblasts
achieved
optimal
effects
in
animal
implantation
experiments.
To
explore
mechanism
biological
responses,
transcriptomics
molecular
biology
experiments
revealed
that
Piezo1/TGF-β1
axis
played
critical
role
response
cells
stimulation
PEEK.
Our
study
established
novel
for
constructing
nanostructures
PEEK,
thereby
promoting
tissues
implants
improving
anchoring
effect.
The Journal of Cell Biology,
Год журнала:
2025,
Номер
224(4)
Опубликована: Янв. 22, 2025
The
process
of
folding
the
flat
neuroectoderm
into
an
elongated
neural
tube
depends
on
tissue
fluidity,
a
property
that
allows
epithelial
deformation
while
preserving
integrity.
Neural
also
requires
planar
cell
polarity
(PCP)
pathway.
Here,
we
report
Prickle2
(Pk2),
core
PCP
component,
increases
fluidity
by
promoting
remodeling
apical
junctions
(AJs)
in
Xenopus
embryos.
This
Pk2
activity
is
mediated
unique
evolutionarily
conserved
Ser/Thr-rich
region
(STR)
carboxyterminal
half
protein.
Mechanistically,
effects
require
Rac1
and
are
accompanied
increased
dynamics
C-cadherin
tricellular
junctions,
hotspots
AJ
remodeling.
Notably,
depletion
leads
to
accumulation
mediolaterally
oriented
cells
neuroectoderm,
whereas
overexpression
or
Pk1
containing
Pk2-derived
STR
promotes
elongation
along
anteroposterior
axis.
We
propose
Pk2-dependent
regulation
contributes
response
extrinsic
cues.
