Physics of Life Reviews, Journal Year: 2024, Volume and Issue: 51, P. 328 - 342
Published: Oct. 24, 2024
Language: Английский
Nature Reviews Molecular Cell Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 29, 2025
Language: Английский
Citations
2
Cell, Journal Year: 2024, Volume and Issue: 187(14), P. 3461 - 3495
Published: June 20, 2024
Developmental biology-the study of the processes by which cells, tissues, and organisms develop change over time-has entered a new golden age. After molecular genetics revolution in 80s 90s diversification field early 21st century, we have phase when powerful technologies provide approaches open unexplored avenues. Progress has been accelerated advances genomics, imaging, engineering, computational biology emerging model systems ranging from tardigrades to organoids. We summarize how revolutionary led remarkable progress understanding animal development. describe classic questions gene regulation, pattern formation, morphogenesis, organogenesis, stem cell are being revisited. discuss connections development with evolution, self-organization, metabolism, time, ecology. speculate developmental might evolve an era synthetic biology, artificial intelligence, human engineering.
Language: Английский
Citations
11
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 14, 2025
Integrin and focal adhesion can regulate cytoskeleton distribution to govern actin-related force remodeling play an important role in nuclear configuration force-sensing mechanotransduction of stem cells. However, further exploration the interaction between actinin complex myosin, kinetics, molecular mechanism structures nucleate within engineered cells is vague. An extensive comprehension cell morphogenesis, remodeling, essential reveal basic physical principles polymerization force-related signaling delivery. Advanced microarrays are designed determine heterogeneous morphology behaviors The heterogeneity from transferred into nuclei by evaluation Lamins, YAP, BrdU expression. Tuning activation proteins nucleators adjust mechanics may be underlying change response its physiological microarrayed
Language: Английский
Citations
1
Nature Reviews Drug Discovery, Journal Year: 2025, Volume and Issue: unknown
Published: March 18, 2025
Language: Английский
Citations
1
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 211, P. 115362 - 115362
Published: June 19, 2024
Language: Английский
Citations
4
Journal of the Mechanics and Physics of Solids, Journal Year: 2025, Volume and Issue: unknown, P. 106032 - 106032
Published: Jan. 1, 2025
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: March 2, 2025
Mechanical force initiates sterile inflammation, a process implicated in diverse physiological and pathological processes. The timely clearance of apoptotic cells by macrophages via efferocytosis is crucial for the proper resolution inflammation averting excessive tissue damage. Despite this, specific role underlying mechanisms mechanical on macrophage remain obscure. By integrating bioinformatics metabolomics analyses, we uncovered how disrupts "arginine metabolism─TCA cycle─mitochondrial function" metabolic cascade, thereby impairing intensifying inflammation. Notably, discovered that elevating l-arginine levels can ameliorate these crises restoring energy metabolism. Leveraging this insight, engineered microneedle drug delivery system loaded with nitric-oxide driven nanomotors (MSN-LA@MNs) targeted l-arginine. active component, MSN-LA, exploits heightened expression inducible nitric oxide synthase (iNOS) force-loaded tissues as chemoattractant, harnessing NO generated from iNOS-catalyzed autonomous propulsion. In force-induced rat orthodontic tooth movement (OTM) model, confirmed MSN-LA@MNs enhance and, under iNOS guidance, dynamically modulate OTM, thus facilitating OTM process. Collectively, our findings elucidate previously unclear mechanistic links between force, efferocytosis, vantage point, offering promising strategy modulating force-related biological processes such OTM.
Language: Английский
Citations
0
Nature Cell Biology, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
Language: Английский
Citations
0
Current Opinion in Cell Biology, Journal Year: 2025, Volume and Issue: 94, P. 102514 - 102514
Published: April 10, 2025
Language: Английский
Citations
0
The Journal of Cell Biology, Journal Year: 2025, Volume and Issue: 224(4)
Published: Jan. 22, 2025
The process of folding the flat neuroectoderm into an elongated neural tube depends on tissue fluidity, a property that allows epithelial deformation while preserving integrity. Neural also requires planar cell polarity (PCP) pathway. Here, we report Prickle2 (Pk2), core PCP component, increases fluidity by promoting remodeling apical junctions (AJs) in Xenopus embryos. This Pk2 activity is mediated unique evolutionarily conserved Ser/Thr-rich region (STR) carboxyterminal half protein. Mechanistically, effects require Rac1 and are accompanied increased dynamics C-cadherin tricellular junctions, hotspots AJ remodeling. Notably, depletion leads to accumulation mediolaterally oriented cells neuroectoderm, whereas overexpression or Pk1 containing Pk2-derived STR promotes elongation along anteroposterior axis. We propose Pk2-dependent regulation contributes response extrinsic cues.
Language: Английский
Citations
0