GeroScience, Год журнала: 2023, Номер 45(5), С. 2785 - 2803
Опубликована: Июнь 1, 2023
Язык: Английский
Science China Life Sciences, Год журнала: 2023, Номер 66(5), С. 893 - 1066
Опубликована: Апрель 11, 2023
Язык: Английский
Процитировано
194
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Май 20, 2024
Abstract Tumor biomarkers, the substances which are produced by tumors or body’s responses to during tumorigenesis and progression, have been demonstrated possess critical encouraging value in screening early diagnosis, prognosis prediction, recurrence detection, therapeutic efficacy monitoring of cancers. Over past decades, continuous progress has made exploring discovering novel, sensitive, specific, accurate tumor significantly promoted personalized medicine improved outcomes cancer patients, especially advances molecular biology technologies developed for detection biomarkers. Herein, we summarize discovery development including history conventional innovative used biomarker classification biomarkers based on tissue origins, application clinical management. In particular, highlight recent advancements biomarker-based anticancer-targeted therapies emerging as breakthroughs promising strategies. We also discuss limitations challenges that need be addressed provide insights perspectives turn into opportunities this field. Collectively, multiple emphasized review may guidance precision medicine, broaden horizons future research directions, expedite patients according their rather than organs origin.
Язык: Английский
Процитировано
134
Immunity & Ageing, Год журнала: 2023, Номер 20(1)
Опубликована: Июнь 8, 2023
Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. entails the immune system characterized by decrease thymic output naïve lymphocytes, an accumulated chronic antigenic stress notably caused infections such as cytomegalovirus (CMV), cell senescence with acquisition inflammatory senescence-associated secretory phenotype (SASP). For this reason, due to SASP originating from other tissues, aging commonly accompanied low-grade inflammation, termed "inflammaging". After decades accumulating evidence regarding age-related processes domain now appears mature enough allow integrative reinterpretation old data. Here, we provide overview topics discussed recent workshop "Aging Chronic Inflammation" which many major players field contributed. We highlight advances systematic measurement interpretation biological markers aging, well their implications for human health longevity interventions that can be envisaged maintain or improve function older people.
Язык: Английский
Процитировано
77
Nature Reviews Cardiology, Год журнала: 2024, Номер 21(9), С. 617 - 631
Опубликована: Апрель 10, 2024
Язык: Английский
Процитировано
68
Nature reviews. Immunology, Год журнала: 2023, Номер 24(1), С. 49 - 63
Опубликована: Июль 14, 2023
Язык: Английский
Процитировано
60
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7047 - 7047
Опубликована: Апрель 11, 2023
Glioblastoma (GBM) is the most common and malignant primary brain cancer in adults. Without treatment mean patient survival approximately 6 months, which can be extended to 15 months with use of multimodal therapies. The low effectiveness GBM therapies mainly due tumor infiltration into healthy tissue, depends on cells’ interaction microenvironment (TME). cells TME involves cellular components such as stem-like cells, glia, endothelial non-cellular extracellular matrix, enhanced hypoxia, soluble factors adenosine, promote GBM’s invasiveness. However, here we highlight role 3D patient-derived glioblastoma organoids cultures a new platform for study modeling In this review, mechanisms involved GBM-microenvironment are described discussed, proposing potential prognosis biomarkers therapeutic targets.
Язык: Английский
Процитировано
56
Frontiers in Endocrinology, Год журнала: 2023, Номер 13
Опубликована: Янв. 16, 2023
Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health expenditures worldwide. Obesity is a significant risk factor for CKD development, partially explained by the high prevalence of diabetes mellitus hypertension in obese patients. However, adipocytes also possess potent endocrine functions, secreting myriad cytokines adipokines that contribute to insulin resistance induce chronic low-grade inflammatory state thereby damaging kidney. development itself associated with various metabolic alterations exacerbate adipose tissue dysfunction resistance. This adipose-renal axis major focus current research, given rising incidence obesity. Cellular senescence biologic hallmark aging, age another obesity CKD. An elevated senescent cell burden predicts renal animal models, senotherapies may alleviate these phenotypes. In this review, we discuss direct mechanisms which contributes emphasizing potential clinical importance such pathways augmenting care
Язык: Английский
Процитировано
46
JCI Insight, Год журнала: 2023, Номер 8(8)
Опубликована: Март 14, 2023
Cisplatin is a widely used chemotherapy drug but it induces both acute and chronic kidney diseases (CKD) in cancer patients. The pathogenesis of cisplatin-induced CKD unclear effective renoprotective approaches are not available. Here, we report that repeated low-dose cisplatin (RLDC) treatment C57BL/6 mice induced cellular senescence tubules, accompanied with tubular degeneration pro-fibrotic phenotype transformation culminated maladaptive repair renal fibrosis. Suppression by senolytic drugs ABT-263 Fisetin attenuated fibrosis improved as indicated restoration regeneration function. In vitro, RLDC also mouse proximal BUMPT cells. eliminated senescent cells following treatment, reversed the increased their clonogenic activity. Moreover, alleviated paracrine effect RLDC-treated on fibroblasts for Consistently, knockdown p16 suppressed post-RLDC fibrotic changes cells, effects fibroblast proliferation. These results indicate persistent induction plays an important role promoting CKD. Targeting may be efficient to improve prevention
Язык: Английский
Процитировано
46
EMBO Reports, Год журнала: 2023, Номер 24(11)
Опубликована: Окт. 9, 2023
Язык: Английский
Процитировано
46
Ageing Research Reviews, Год журнала: 2024, Номер 97, С. 102294 - 102294
Опубликована: Апрель 5, 2024
Язык: Английский
Процитировано
33