GeroScience, Год журнала: 2023, Номер 45(5), С. 2785 - 2803
Опубликована: Июнь 1, 2023
Язык: Английский
Advanced Science, Год журнала: 2024, Номер 11(13)
Опубликована: Янв. 29, 2024
Abstract Delayed wound healing is a major complication of diabetes, and associated with impaired cellular functions. Current treatments are unsatisfactory. Based on the previous reports microRNA expression in small extracellular vesicles (sEVs), miR‐17‐5p‐engineered sEVs (sEVs 17‐OE ) encapsulated them gelatin methacryloyl (GelMA) hydrogel for diabetic wounds treatment fabricated. SEVs successfully fabricated 16‐fold increase miR‐17‐5p expression. inhibited senescence promoted proliferation, migration, tube formation high glucose‐induced human umbilical vein endothelial cells (HG‐HUVECs). Additionally, also performs promotive effect dermal fibroblasts (HG‐HDFs). Mechanism analysis showed expressions p21 phosphatase tensin homolog (PTEN), as target genes miR‐17‐5p, downregulated significantly by . Accordingly, downstream pathways PTEN, activated. Next, loaded GelMA to fabricate novel bioactive dressing evaluate their effects healing. Gel‐sEVs effectively accelerated promoting angiogenesis collagen deposition. The mechanism may be local cell proliferation. Therefore, loading hydrogel, offering an option chronic management
Язык: Английский
Процитировано
26
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(4), С. 1508 - 1524
Опубликована: Янв. 20, 2024
Macrophage senescence, manifested by the special form of durable cell cycle arrest and chronic low-grade inflammation like senescence-associated secretory phenotype, has long been considered harmful. Persistent senescence macrophages may lead to maladaptation, immune dysfunction, finally development age-related diseases, infections, autoimmune malignancies. However, it is a ubiquitous, multi-factorial, dynamic complex phenomenon that also plays roles in remodeled processes, including wound repair embryogenesis. In this review, we summarize some general molecular changes several specific biomarkers during macrophage which bring new sight recognize senescent different conditions. Also, take an in-depth look at functional macrophages, metabolism, autophagy, polarization, phagocytosis, antigen presentation, infiltration or recruitment. Furthermore, degenerations diseases associated with as well mechanisms relevant genetic regulations are integrated, not only emphasizing possibility regulating benefit age-associated but implication on finding potential targets drugs clinically.
Язык: Английский
Процитировано
21
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Фев. 5, 2024
Abstract Cellular senescence represents an irreversible state of cell-cycle arrest during which cells secrete senescence-associated secretory phenotypes, including inflammatory factors and chemokines. Additionally, these exhibit apoptotic resistance phenotype. serves a pivotal role not only in embryonic development, tissue regeneration, tumor suppression but also the pathogenesis age-related degenerative diseases, malignancies, metabolic kidney diseases. The renal tubular epithelial (RTEC) constitutes critical cellular event progression acute injury (AKI). RTEC inhibits regeneration repair processes and, concurrently, promotes transition AKI to chronic disease via mechanisms underlying are multifaceted include telomere shortening or damage, DNA mitochondrial autophagy deficiency, disorders, endoplasmic reticulum stress, epigenetic regulation. Strategies aimed at inhibiting senescence, targeting clearance senescent RTEC, promoting apoptosis hold promise for enhancing prognosis AKI. This review primarily focuses on characteristics impact intervening AKI, aiming provide foundation understanding providing potentially effective approaches treatment.
Язык: Английский
Процитировано
20
Nature Reviews Gastroenterology & Hepatology, Год журнала: 2024, Номер 21(7), С. 477 - 492
Опубликована: Март 14, 2024
Язык: Английский
Процитировано
19
Cells, Год журнала: 2024, Номер 13(5), С. 441 - 441
Опубликована: Март 2, 2024
Oxidative stress refers to the imbalance between production of reactive oxygen species (ROS) and endogenous antioxidant defense system. Its involvement in cell senescence, apoptosis, series diseases has been demonstrated. Advances carcinogenic research have revealed oxidative as a pivotal pathophysiological pathway tumorigenesis be involved lung cancer, glioma, hepatocellular carcinoma, leukemia, so on. This review combs effects on each phase fate determination, three features are discussed. takes part processes ranging from tumor death via pathways like mitochondrial stress, endoplasmic reticulum ferroptosis. It can affect by engaging complex relationships death, cancer. The influence progression is multi-stage interlaced process that includes two aspects promotion inhibition, with mitochondria core regulation. A deeper more comprehensive understanding conducive exploring therapies.
Язык: Английский
Процитировано
18
Autophagy, Год журнала: 2024, Номер 20(9), С. 2000 - 2016
Опубликована: Май 18, 2024
Bleomycin exhibits effective chemotherapeutic activity against multiple types of tumors, and also induces various side effects, such as pulmonary fibrosis neuronal defects, which limit the clinical application this drug. Macroautophagy/autophagy has been recently reported to be involved in functions bleomycin, yet mechanisms their crosstalk remain insufficiently understood. Here, we demonstrated that reactive oxygen species (ROS) produced during bleomycin activation hampered autophagy flux by inducing lysosomal membrane permeabilization (LMP) obstructing degradation. Exhaustion ROS with N-acetylcysteine relieved LMP defects. Notably, observed blockage preceded emergence cellular senescence treatment. In addition, promoting or inhibiting autophagy-lysosome degradation alleviated exacerbated phenotypes senescence, respectively. This suggests alternation is more a regulatory mechanism than consequence bleomycin-induced senescence. Taken together, reveal specific role mediating defects autophagic further regulating vitro vivo. Our findings, conversely, indicate pathway target for modulating bleomycin. These provide new perspective optimizing clinically applicable chemotherapeutics devoid severe side-effects.
Язык: Английский
Процитировано
18
Nature Reviews Nephrology, Год журнала: 2024, Номер 20(9), С. 603 - 615
Опубликована: Июль 18, 2024
Язык: Английский
Процитировано
18
Metabolism, Год журнала: 2024, Номер 154, С. 155811 - 155811
Опубликована: Фев. 2, 2024
Язык: Английский
Процитировано
16
Cell Metabolism, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
4
Advanced Therapeutics, Год журнала: 2025, Номер unknown
Опубликована: Янв. 6, 2025
Abstract The extracellular matrix (ECM) serves not only as a structural scaffold but also an active regulator of cancer progression, profoundly influencing tumor behaviour and the microenvironment (TME). This review focuses into pivotal role ECM alterations in facilitating metastasis explores therapeutic strategies aimed at counteracting these changes. We analyse targeted interventions against collagen, including approaches to inhibit its biosynthesis disrupt associated signalling pathways critical for architecture cell migration. Additionally, therapies addressing hyaluronan are reviewed, highlighting methods suppress synthesis enzymatic degrade it, thereby mitigating tumor‐promoting effects. discussion extends innovative modulating stiffness, focusing on roles cancer‐associated fibroblasts lysyl oxidases, which key contributors remodelling mechanical signalling. By strategically modifying components, aim enhance efficacy existing treatments, tackle resistance mechanisms, achieve more durable outcomes. Insights from recent studies clinical trials highlight promise overcoming treatment improving patient Advancing our understanding biology leads development effective therapies.
Язык: Английский
Процитировано
2