Molecular Neurodegeneration,
Год журнала:
2020,
Номер
15(1)
Опубликована: Ноя. 4, 2020
Abstract
Investigations
of
apolipoprotein
E
(
APOE
)
gene,
the
major
genetic
risk
modifier
for
Alzheimer’s
disease
(AD),
have
yielded
significant
insights
into
pathogenic
mechanism.
Among
three
common
coding
variants,
APOE*ε4
increases,
whereas
APOE*ε2
decreases
late-onset
AD
compared
with
APOE*ε3
.
Despite
increased
understanding
detrimental
effect
,
it
remains
unclear
how
confers
protection
against
AD.
Accumulating
evidence
suggests
that
protects
through
both
amyloid-β
(Aβ)-dependent
and
independent
mechanisms.
In
addition,
has
been
identified
as
a
longevity
suggesting
systemic
on
aging
process.
However,
is
not
entirely
benign;
carriers
exhibit
certain
cerebrovascular
diseases
neurological
disorders.
Here,
we
review
from
human
animal
studies
demonstrating
protective
propose
working
model
depicting
potential
underlying
Finally,
discuss
therapeutic
strategies
designed
to
leverage
APOE2
treat
Ageing Research Reviews,
Год журнала:
2020,
Номер
64, С. 101045 - 101045
Опубликована: Март 19, 2020
As
the
population
ages,
number
of
people
with
dementia
is
expected
to
increase
in
coming
decades,
consequences
at
societal
and
individual
levels.
In
this
narrative
review,
we
provide
a
summary
scientific
evidence
concerning
prevention,
focus
on
following
three
strategies:
1)
Targeting
body
protect
brain,
including
prevention
treatment
cardiovascular
morbidity;
2)
Compensatory
interventions
counteract
brain
ageing,
education
life-long
engagement
cognitively
socially
stimulating
activities;
3)
Lifespan
health
promotion,
such
as
physically
active
lifestyle,
smoking
cessation,
healthy
balanced
diet.
Next,
consider
biological
mechanisms
by
which
these
strategies
may
act
taking
into
account
main
pathways
implicated
development
progression
dementia:
neurodegeneration,
resilience,
vascular
damage,
neuroinflammation,
oxidative
stress.
Based
current
evidence,
line
declining
trends
incidence
high-income
countries,
conclude
that
timely
multidomain
preventive
actions
are
promising
reduce
epidemic
worldwide.
There
still
considerable
gap
between
epidemiological
its
underlying
mechanisms.
Filling
will
be
crucial
move
forward
