The role of microglia in multiple sclerosis: implications for treatment with Bruton’s tyrosine kinase inhibitors DOI Creative Commons
Patrick Vermersch, Laura Airas, Thomas Berger

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 15, 2025

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), characterized by inflammation and neurodegeneration. The pathophysiology of MS, especially its progressive forms, involves various cellular components, including microglia, primary resident immune cells CNS. This review discusses role microglia in neuroinflammation, tissue repair, neural homeostasis, as well their involvement MS explores potential therapeutic strategies targeting microglial function. A literature search conducted August 2023 updated March 2025, using PubMed database, focused on articles relating to published 2018-2025. Additionally, ongoing clinical trials Bruton's tyrosine kinase (BTK) inhibitors were identified through ClinicalTrials.gov website November 2025. Microglia are highly adaptive exhibit functional states throughout different life stages play critical roles homeostasis. Their altered activity prominent feature contributing pathogenesis. Imaging techniques such magnetic resonance imaging (MRI) positron emission tomography (PET) provide insights into MS. BTK other novel treatments for masitinib frexalimab, show promise modulating function influencing progression rate. multifaceted CNS development, surveillance, particularly pathogenesis highlight functions treatment. Emerging research offers promising avenues developing therapies, potentially improving patient outcomes this debilitating disease.

Язык: Английский

Multiple sclerosis DOI
Dejan Jakimovski, Stefan Bittner, Robert Zivadinov

и другие.

The Lancet, Год журнала: 2023, Номер 403(10422), С. 183 - 202

Опубликована: Ноя. 7, 2023

Язык: Английский

Процитировано

198
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting DOI Creative Commons
Marc Charabati, Michael A. Wheeler, Howard L. Weiner

и другие.

Cell, Год журнала: 2023, Номер 186(7), С. 1309 - 1327

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

123
Microglia in multiple sclerosis: Protectors turn destroyers DOI Creative Commons
V. Wee Yong

Neuron, Год журнала: 2022, Номер 110(21), С. 3534 - 3548

Опубликована: Июль 25, 2022

Язык: Английский

Процитировано

95
Positron Emission Tomography with [18F]‐DPA‐714 Unveils a Smoldering Component in Most Multiple Sclerosis Lesions which Drives Disease Progression DOI Creative Commons
Mariem Hamzaoui, J. Garcia, Giacomo Boffa

и другие.

Annals of Neurology, Год журнала: 2023, Номер 94(2), С. 366 - 383

Опубликована: Апрель 11, 2023

To determine the prognostic value of persisting neuroinflammation in multiple sclerosis (MS) lesions, we developed a 18 kDa-translocator-protein-positron emission tomography (PET) -based classification each lesion according to innate immune cell content and localization. We assessed respective predictive phenotype diffuse inflammation on atrophy disability progression over 2 years.Thirty-six people with MS (disease duration 9 ± 6 years; 12 relapsing-remitting, 13 secondary-progressive, 11 primary-progressive) 19 healthy controls (HCs) underwent dynamic [18 F]-DPA-714-PET. At baseline after years, patients also magnetic resonance imaging (MRI) neurological examination. Based threshold significant defined by comparison F]-DPA-714 binding between HCs, white matter lesions were classified as homogeneously active (active center), rim-active (inactive center periphery), or nonactive. Longitudinal cortical was measured using Jacobian integration.Patients had higher normal-appearing (NAWM) cortex than HCs (respective standardized effect size = 1.15, 0.89, p 0.003 < 0.001). Out 1,335 non-gadolinium-enhancing 53% homogeneously-active (median 17 per patient MS), 6% 1 41% non-active 14 MS). The number homogenously-active strongest predictor longitudinal changes, associating (β 0.49, 0.023) Expanded Disability Status Scale (EDSS) changes 0.35, years. NAWM not associated volumetric clinical changes.The F]-DPA-714-PET revealed that an unexpectedly high proportion have smoldering component, which predicts progression. This suggests following acute phase, most develop chronic inflammatory promoting neurodegeneration ANN NEUROL 2023;94:366-383.

Язык: Английский

Процитировано

44
Lanthanide porphyrinoids as molecular theranostics DOI
Guoqing Jin, Calvin V. Chau, Jonathan F. Arambula

и другие.

Chemical Society Reviews, Год журнала: 2022, Номер 51(14), С. 6177 - 6209

Опубликована: Янв. 1, 2022

This Review summarises the history and ‘state-of-the-art’ development of lanthanide (Ln) porphyrinoids as theranostic agents. Applications such near-infrared (NIR) fluorescence imaging (FL), magnetic resonance (MRI), radiotherapy, chemotherapy phototheranostics will be discussed.

Язык: Английский

Процитировано

63
Imaging Characteristics of Choroid Plexuses in Presymptomatic Multiple Sclerosis DOI Creative Commons
Vito A. G. Ricigliano, Céline Louapre,

Émilie Poirion

и другие.

Neurology Neuroimmunology & Neuroinflammation, Год журнала: 2022, Номер 9(6)

Опубликована: Окт. 13, 2022

Objectives

To explore how e-cigarettes are being promoted at point of sale in the UK and retailers perceive market trends.

Setting

Fixed retail outlets subject to a ban on display tobacco products.

Participants

Observational audit all stores selling products (n=96) 4 Scottish communities, conducted over 2 waves 12 months apart (2013–2014), qualitative interviews with small (n=25) matched communities.

Primary secondary outcome measures

The measured e-cigarette characteristics, advertising materials proximity other products, differences by area-level disadvantage. Interviews explored retailers' perceptions opportunities risks, customer responses.

Results

number point-of-sale units brands displayed increased between waves. E-cigarettes were close interest children 36% stores. Stores more affluent areas less likely have external than those deprived areas. Although delivered high profit margins, confused diversity uncertain sector9s viability. Some customers perceived purchase as cessation aids, others, particularly low-income smokers, cheaper adjunct conventional tobacco.

Conclusions

E-cigarette displays months, potential cause for concern given their lack regulation. Further scrutiny is needed content effects such advertising, potentially normalising placing next children.

Язык: Английский

Процитировано

43
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration DOI Creative Commons
Mattéo Tonietto,

Émilie Poirion,

Andrea Lazzarotto

и другие.

Brain, Год журнала: 2022, Номер 146(1), С. 182 - 194

Опубликована: Сен. 10, 2022

In multiple sclerosis, spontaneous remyelination is generally incomplete and heterogeneous across patients. A high heterogeneity in may also exist lesions within the same individual, suggesting presence of local factors interfering with myelin regeneration. this study we explored vivo regional distribution repair investigated its relationship neurodegeneration. We first took advantage binding property amyloid radiotracer 11C-PiB to conduct a longitudinal PET an original cohort 19 participants relapsing-remitting form followed-up over period 1-4 months. then replicated our results on independent 40 people sclerosis 1 year magnetization transfer imaging, MRI metrics sensitive content. For each imaging method, voxel-wise maps content changes were generated according modality-specific thresholds. demonstrated selective failure periventricular white matter both cohorts. replication cohort, estimated that probability demyelinated voxels remyelinate follow-up increased significantly as function distance from ventricular CSF. Enlarged choroid plexus, recently discovered biomarker linked neuroinflammation, was found be associated two cohorts (r = -0.79, P 0.0018; r -0.40, 0.045, respectively), role brain-CSF barrier affecting surrounding tissues. cohorts, lower thalamic volume 0.86, < 0.0001; 0.33; 0.069, marker Interestingly, showed association between cortical atrophy mediated by number cortex-derived tracts passing through lesions, especially patients at stage. Our findings demonstrate lesion proximity ventricles support hypothesis combination large connecting areas key mechanism contributing damage sclerosis.

Язык: Английский

Процитировано

40
Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders DOI Creative Commons

Yi Song,

Jian Li, Yuzhang Wu

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 4, 2024

Autoimmune disorders are characterized by aberrant T cell and B reactivity to the body's own components, resulting in tissue destruction organ dysfunction. diseases affect a wide range of people many parts world have become one major concerns public health. In recent years, there been substantial progress our understanding epidemiology, risk factors, pathogenesis mechanisms autoimmune diseases. Current approved therapeutic interventions for mainly non-specific immunomodulators may cause broad immunosuppression that leads serious adverse effects. To overcome limitations immunosuppressive drugs treating diseases, precise target-specific strategies urgently needed. date, significant advances made immune tolerance, offering new avenue developing antigen-specific immunotherapies These approaches shown great potential various preclinical animal models recently evaluated clinical trials. This review describes common manifestation with focus on typical including multiple sclerosis, type 1 diabetes, rheumatoid arthritis, systemic lupus erythematosus, sjögren's syndrome. We discuss current therapeutics developed this field, highlight use nanomaterials mRNA vaccine techniques induce tolerance.

Язык: Английский

Процитировано

13
An update on the role of magnetic resonance imaging in predicting and monitoring multiple sclerosis progression DOI Creative Commons
Piriyankan Ananthavarathan, Nitin Sahi, Declan Chard

и другие.

Expert Review of Neurotherapeutics, Год журнала: 2024, Номер 24(2), С. 201 - 216

Опубликована: Янв. 18, 2024

Introduction While magnetic resonance imaging (MRI) is established in diagnosing and monitoring disease activity multiple sclerosis (MS), its utility predicting progression less clear.

Язык: Английский

Процитировано

11
Remyelination in the Central Nervous System DOI
Robin J.M. Franklin, Benedetta Bodini, Steven A. Goldman

и другие.

Cold Spring Harbor Perspectives in Biology, Год журнала: 2024, Номер 16(3), С. a041371 - a041371

Опубликована: Фев. 5, 2024

Robin J.M. Franklin1, Benedetta Bodini2,3 and Steven A. Goldman4,5 1Altos Labs Cambridge Institute of Science, CB21 6GH, United Kingdom 2Sorbonne Université, Paris Brain Institute, CNRS, INSERM, 75013, France 3Saint-Antoine Hospital, APHP, 75012, 4Center for Translational Neuromedicine, University Rochester Medical Center, Rochester, New York 14642, USA 5University Copenhagen Faculty Medicine, 2200, Denmark Correspondence: rfranklin{at}altoslabs.com

Язык: Английский

Процитировано

10