Tantalum–Zirconium Co‐Doped Metal–Organic Frameworks Sequentially Sensitize Radio–Radiodynamic–Immunotherapy for Metastatic Osteosarcoma

Advanced Science, Год журнала: 2023, Номер 10(10)

Опубликована: Фев. 5, 2023

Due to radiation resistance and the immunosuppressive microenvironment of metastatic osteosarcoma, novel radiosensitizers that can sensitize radiotherapy (RT) antitumor immunity synchronously urgently needed. Here, authors developed a nanoscale metal-organic framework (MOF, named TZM) by co-doping high-atomic elements Ta Zr as metal nodes porphyrinic molecules (tetrakis(4-carboxyphenyl)porphyrin (TCPP)) photosensitizing ligand. Given 3D arrays ultra-small heavy metals, porous TZM serves an efficient attenuator absorbing X-ray energy sensitizing hydroxyl radical generation for RT. Ta-Zr narrowed highest occupied molecular orbital-lowest unoccupied orbital (HOMO-LUMO) gap exhibited close levels between singlet triplet photoexcited states, facilitating transfer photosensitizer TCPP oxygen (

Язык: Английский

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Small molecular cyanine dyes for phototheranostics

Coordination Chemistry Reviews, Год журнала: 2024, Номер 516, С. 215986 - 215986

Опубликована: Июнь 2, 2024

Язык: Английский

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Functionalization of luminescent lanthanide complexes for biomedical applications

Coordination Chemistry Reviews, Год журнала: 2022, Номер 474, С. 214866 - 214866

Опубликована: Окт. 8, 2022

Язык: Английский

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A pillar[5]arene noncovalent assembly boosts a full-color lanthanide supramolecular light switch

Chemical Science, Год журнала: 2023, Номер 14(23), С. 6457 - 6466

Опубликована: Янв. 1, 2023

A photo-responsive full-color lanthanide supramolecular switch was constructed from a synthetic 2,6-pyridine dicarboxylic acid (DPA)-modified pillar[5]arene (H) complexing with ion (Ln3+ = Tb3+ and Eu3+) dicationic diarylethene derivative (G1) through noncovalent assembly. Benefiting the strong complexation between DPA Ln3+ 3 : 1 stoichiometric ratio, complex H/Ln3+ presented an emerging emission in aqueous organic phase. Subsequently, network polymer formed by further encapsulating G1via hydrophobic cavity of pillar[5]arene, which greatly contributed to increased intensity lifetime, also resulted formation light switch. Moreover, luminescence, especially white emission, achieved (CIE: 0.31, 0.32) dichloromethane 0.33) solutions adjustment different ratios Eu3+. Notably, photo-reversible luminescence properties assembly were tuned via alternant UV/vis irradiation due conformation-dependent photochromic energy transfer open/closed-ring diarylethene. Ultimately, prepared successfully applied anti-counterfeiting use intelligent multicolored writing inks, presents new opportunities for design advanced stimuli-responsive on-demand color tuning luminescent materials.

Язык: Английский

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Activatable Janus Nanoparticles for Precise NIR‐II Bioimaging and Synergistic Cancer Therapy

Advanced Functional Materials, Год журнала: 2024, Номер 34(27)

Опубликована: Фев. 25, 2024

Abstract Despite multifunctional theranostics hold vast potential in deep tissue bioimaging and tumor therapy, activatable nanomedicine with integration of precise diagnosis effective treatment is usually achieved at the cost complicated synthesis chemistries. Here, a facile way to design bioresponsive Ag 2 S‐Ag Janus probes coated by polyethylene glycol (PEG) (denoted as AAP) showed, active second near‐infrared window (NIR‐II, 1000–1700 nm). In microenvironment, part can yield hydroxyl radicals (·OH) consuming H O for high‐efficiency chemodynamic therapy (CDT), while S has impressive photothermal (PTT). The synergistic benefits from parts further boosted CDT effect AAP high conversion efficiency up 56.8%. Moreover, multiple lines evidence supported that extremely faint fluorescence be significantly activated overexpressed levels , showing bright NIR‐II emission ≈1270 nm over 5.6 × 10 3 ‐fold increase signal intensity. are easily imaging tumor‐specific identification, effectively ablate tissues inhibition rate 96.2%. This study expects probe will open new route achieve window.

Язык: Английский

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Targeted Cyclo[8]pyrrole-Based NIR-II Photoacoustic Tomography Probe for Suppression of Orthotopic Pancreatic Tumor Growth and Intra-abdominal Metastases

Journal of the American Chemical Society, Год журнала: 2024, Номер 146(7), С. 4620 - 4631

Опубликована: Фев. 8, 2024

Pancreatic cancer is highly lethal. New diagnostic and treatment modalities are desperately needed. We report here that an expanded porphyrin, cyclo[8]pyrrole (CP), with a high extinction coefficient (89.16 L/g·cm) within the second near-infrared window (NIR-II), may be formulated αvβ3-specific targeting peptide, cyclic-Arg-Gly-Asp (cRGD), to form cRGD-CP nanoparticles (cRGD-CPNPs) promising NIR-II photothermal (PT) therapeutic photoacoustic (PA) imaging properties. Studies ring-array PA tomography system, coupled analysis of control lacking element (CPNPs), revealed cRGD conjugation promoted delivery NPs through abnormal vessels around tumor solid core. This proved true in both subcutaneous orthotopic pancreatic mice models, as confirmed by immunofluorescent studies. In combination laser photoirradiation, cRGD-CPNPs provided near-baseline growth inhibition PTT vitro vivo. Notably, present photoirradiation was found inhibit intra-abdominal metastases mouse model. The also displayed good biosafety profiles, inferred from tomography, blood analyses, H&E staining. They thus appear for use combined PT cancer.

Язык: Английский

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Rare Earths—The Answer to Everything

Molecules, Год журнала: 2024, Номер 29(3), С. 688 - 688

Опубликована: Фев. 1, 2024

Rare earths, scandium, yttrium, and the fifteen lanthanoids from lanthanum to lutetium, are classified as critical metals because of their ubiquity in daily life. They present magnets cars, especially electric cars; green electricity generating systems computers; steel manufacturing; glass light emission materials for safety lighting lasers; exhaust catalysts supports; artificial rubber production; agriculture animal husbandry; health cancer diagnosis treatment; a variety electronic products essential modern living. have potential replace toxic chromates corrosion inhibition, magnetic refrigeration, new materials, role may expand. This review examines sustainability, environment, recycling, crop production, feedstocks, catalysis, health, well considering future uses.

Язык: Английский

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Luminescent Lanthanides in Biorelated Applications: From Molecules to Nanoparticles and Diagnostic Probes to Therapeutics

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Lanthanides are particularly effective in their clinical applications magnetic resonance imaging and diagnostic assays. They have open-shell 4f electrons that give rise to characteristic narrow, line-like emission which is unique from other fluorescent probes biological systems. Lanthanide luminescence signal offers selection of detection pathways based on the choice ion visible near-infrared with long lifetimes lend themselves time-resolved measurements for optical multiplexing schemes novel bioimaging applications. The delivery lanthanide agents cells allows localized bioresponsive activity therapies. Detection region spectrum coupled technological advances microscopies opens new avenues deep-tissue surgical interventions. This review focuses different ways can be exploited nucleic acid enzyme detection, anion recognition, cellular imaging, tissue photoinduced therapeutic We focused hierarchy designs include luminescent lanthanides as biology considering coordination complexes, multimetallic systems metal-organic frameworks nanoparticles highlighting strategies downshifting, upconversion revealing some opportunities challenges offer potential further development field.

Язык: Английский

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Tunable Multicolor Lanthanide Supramolecular Assemblies with White Light Emission Confined by Cucurbituril[7]

Small, Год журнала: 2023, Номер 19(46)

Опубликована: Июль 13, 2023

Macrocyclic confinement-induced supramolecular luminescence materials have important application value in the fields of bio-sensing, cell imaging, and information anti-counterfeiting. Herein, a tunable multicolor lanthanide assembly with white light emission is reported, which constructed by co-assembly cucurbit[7]uril (CB[7]) encapsulating naphthylimidazolium dicarboxylic acid (G1 )/Ln (Eu3+ /Tb3+ ) complex carbon quantum dots (CD). Benefiting from macrocyclic confinement effect CB[7], not only extends fluorescence intensity G1 36 times, but also increases yield 28 times lifetime 12 times. Furthermore, CB[7]/G1 /Ln can further co-assemble CD diarylethene derivatives (DAE) to realize intelligently-regulated full-color spectrum including light, results competitive encapsulation adamantylamine change pH, photochromic DAE. The multi-level logic gate based on successfully applied anti-counterfeiting system storage, providing an effective method for research new luminescent intelligent materials.

Язык: Английский

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Bioresponsive fluorescent probes active in the second near‐infrared window

iRadiology, Год журнала: 2023, Номер 1(1), С. 36 - 60

Опубликована: Март 1, 2023

Abstract Emerging stimuli‐responsive composite probes active in the second near‐infrared window (NIR‐II, 1000–1700 nm) hold vast potential for improving vivo imaging performance with minimized noise interference. The interactions among external irradiation, shell species, and emissive core are key factors design of smart structures. irradiation provides energy species to generate intense NIR‐II fluorescence signals, while transfer process hinders emission inner structure probes. However, if pathophysiological stimuli interrupt above processes, then signals recovered. This review covers based on diverse fluorescent responding various biological stimuli, including ONOO − , overexpressed reactive sulfur abnormally expressed enzymes, abnormal levels physiological metabolites. Finally, appreciate these advances, challenges perspectives highlighted.

Язык: Английский

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