Adaptative
action
selection
in
threatening
social
contexts,
for
example
when
facing
aggressive
individuals,
is
core
to
behavior.
It
debated
whether,
threat,
initial
opportunities
are
mostly
determined
by
automatic
tendencies
–
i.e.,
reactive
stimulus-response
(SR)
associations
or
rapid
and
implicit
goal-directed
(GD)
processes,
which
depend
on
the
predicted
consequences
of
available
actions.
To
investigate
balance
between
SR
GD,
we
conducted
three
experiments
manipulating
predictability
action-outcomes
associations,
a
novel
approach-avoidance
decision
task
virtual
reality.
Participants
presented
greater
avoidance
rate
from
angry
individuals
action-outcome
association
was
predictable.
Computationally,
this
subtended
more
efficient
evidence
accumulation,
as
indicated
an
increased
drift
rate.
Furthermore,
cardiac
deceleration
around
time
choice
predictable
condition
allowed
value
attributed
outcome
be
better
integrated
into
decision.
Finally,
while
most
participants
avoided
only
under
predictability,
supporting
predominant
role
GD
minority
them
regardless
predictability.
Overall,
our
results
shed
light
computational
architecture
avoidance,
opening
interesting
new
research
clinical
perspectives.
Cognitive Affective & Behavioral Neuroscience,
Год журнала:
2024,
Номер
24(2), С. 228 - 245
Опубликована: Фев. 14, 2024
Abstract
Anxiety
disorders
affect
millions
of
people
worldwide
and
present
a
challenge
in
neuroscience
research
because
their
substantial
heterogeneity
clinical
presentation.
While
great
deal
progress
has
been
made
understanding
the
neurobiology
fear
anxiety,
these
insights
have
not
led
to
effective
treatments.
Understanding
relationship
between
phenotypic
underlying
biology
is
critical
first
step
solving
this
problem.
We
show
translation,
reverse
computational
modeling
can
contribute
refined,
cross-species
anxiety
as
well
disorders.
More
specifically,
we
outline
how
animal
models
be
leveraged
develop
testable
hypotheses
humans
by
using
targeted,
approaches
ethologically
informed
behavioral
paradigms.
discuss
translational
that
guide
prioritize
nontraditional
species.
Finally,
advocate
for
use
harmonize
cross-methodology
into
anxiety.
Together,
approach
will
help
bridge
widening
gap
currently
conceptualize
diagnose
disorders,
aid
discovery
better
treatments
conditions.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1087 - 1087
Опубликована: Янв. 27, 2025
As
the
first
line
of
host
immune
defense,
innate
immunity
plays
a
key
role
in
warding
off
foreign
pathogens
and
damage.
Drosophila
melanogaster,
as
classical
model
animal
for
more
than
100
years,
is
an
important
research
studying
immunity.
In
recent
scientists
have
made
remarkable
progress
recognition
mechanisms
immunity,
effector
molecules,
modes
their
response
at
cellular
tissue
levels.
However,
interaction
between
other
physiological
functions
remains
relatively
novel
has
yet
to
be
systematically
explored.
Here,
we
briefly
discuss
link
system
regulation,
from
several
representative
perspectives
such
sleep,
insulin,
brain
function.
Then,
using
model,
provide
overview
specifically
summarize
on
regulation
physiology
by
covering
lipid
metabolism,
development,
neurodegenerative
diseases,
memory,
feeding,
lifespan,
movement,
antioxidation.
This
review
provides
valuable
into
how
influences
processes,
providing
deeper
understanding
complex
roles
underlying
Animals,
Год журнала:
2024,
Номер
14(2), С. 296 - 296
Опубликована: Янв. 17, 2024
Animals
are
under
constant
threat
of
parasitic
infection.
This
has
influenced
the
evolution
social
behaviour
and
strong
implications
for
sexual
selection
mate
choice.
assess
infection
status
conspecifics
based
on
various
sensory
cues,
with
odours/chemical
signals
olfactory
system
playing
a
particularly
important
role.
The
detection
chemical
cues
subsequent
processing
that
they
pose
facilitates
expression
disgust,
fear,
anxiety,
adaptive
avoidance
behaviours.
In
this
selective
review,
drawing
primarily
from
rodent
studies,
neurobiological
mechanisms
underlying
assessment
their
relations
to
choice
briefly
considered.
Firstly,
we
offer
brief
overview
aspects
relevant
pathogen
avoidance.
Then,
specifically
focus
responses
conspecific
infection,
followed
by
systems
elicitation
disgust
threat.
Throughout,
current
findings
provide
suggestions
future
directions
research.
