Neuroscience Bulletin,
Journal Year:
2024,
Volume and Issue:
40(11), P. 1713 - 1731
Published: Nov. 1, 2024
Abstract
The
functional
role
of
glutamatergic
(vGluT2)
neurons
in
the
pedunculopontine
nucleus
(PPN)
modulating
motor
activity
remains
controversial.
Here,
we
demonstrated
that
vGluT2
rostral
PPN
is
correlated
with
locomotion
and
ipsilateral
head-turning.
Beyond
these
functions,
found
PPN-vGluT2
remarkably
respond
to
salient
stimuli.
Furthermore,
systematically
traced
upstream
downstream
projections
identified
two
from
caudal
pontine
reticular
nucleus/anterior
gigantocellular
(PnC/GiA)
zona
incerta
(ZI).
Our
findings
indicate
PnC/GiA
inhibit
movement,
consistent
‘pause-and-play’
behavior,
whereas
those
ZI
promote
locomotion,
others
a
new
‘pause-switch-play’
pattern.
Collectively,
elucidate
multifaceted
influence
on
functions
provide
robust
theoretical
framework
for
understanding
its
physiological
potential
therapeutic
implications.
Cognitive Affective & Behavioral Neuroscience,
Journal Year:
2024,
Volume and Issue:
24(2), P. 228 - 245
Published: Feb. 14, 2024
Abstract
Anxiety
disorders
affect
millions
of
people
worldwide
and
present
a
challenge
in
neuroscience
research
because
their
substantial
heterogeneity
clinical
presentation.
While
great
deal
progress
has
been
made
understanding
the
neurobiology
fear
anxiety,
these
insights
have
not
led
to
effective
treatments.
Understanding
relationship
between
phenotypic
underlying
biology
is
critical
first
step
solving
this
problem.
We
show
translation,
reverse
computational
modeling
can
contribute
refined,
cross-species
anxiety
as
well
disorders.
More
specifically,
we
outline
how
animal
models
be
leveraged
develop
testable
hypotheses
humans
by
using
targeted,
approaches
ethologically
informed
behavioral
paradigms.
discuss
translational
that
guide
prioritize
nontraditional
species.
Finally,
advocate
for
use
harmonize
cross-methodology
into
anxiety.
Together,
approach
will
help
bridge
widening
gap
currently
conceptualize
diagnose
disorders,
aid
discovery
better
treatments
conditions.
Frontiers in Psychology,
Journal Year:
2024,
Volume and Issue:
15
Published: Oct. 2, 2024
The
evidence
base
for
the
effectiveness
of
art
therapy
continues
to
grow,
even
as
a
mechanistic
understanding
how
works
remains
limited.
One
promising
avenue
increasing
our
and
why
is
through
lens
neuroscience.
A
neuroscience-based
approach
provides
opportunities
improving
neural
processes
that
underlie
complex
interaction
between
perception,
cognition,
emotion
behavior
play
out
in
process.
Understanding
therapeutic
change
occurs
can
result
improved
treatment
better
outcomes
clients.
However,
it
be
tricky
connect
psychological
theory
directly
responses.
purposes
this
perspective
are
provide
an
overview
current
limits
neurobiological
concepts
neuroplasticity,
mirror
systems,
interoception
applied
practice,
updated
information
about
outdated
still
actively
used
clinical
practice.
Critical
analysis
scientific
knowledge
then
guide
practice
support
development
hypothesis-based
research
determine
primary
mechanisms
drive
observed
effects
interventions.
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(3), P. 1087 - 1087
Published: Jan. 27, 2025
As
the
first
line
of
host
immune
defense,
innate
immunity
plays
a
key
role
in
warding
off
foreign
pathogens
and
damage.
Drosophila
melanogaster,
as
classical
model
animal
for
more
than
100
years,
is
an
important
research
studying
immunity.
In
recent
scientists
have
made
remarkable
progress
recognition
mechanisms
immunity,
effector
molecules,
modes
their
response
at
cellular
tissue
levels.
However,
interaction
between
other
physiological
functions
remains
relatively
novel
has
yet
to
be
systematically
explored.
Here,
we
briefly
discuss
link
system
regulation,
from
several
representative
perspectives
such
sleep,
insulin,
brain
function.
Then,
using
model,
provide
overview
specifically
summarize
on
regulation
physiology
by
covering
lipid
metabolism,
development,
neurodegenerative
diseases,
memory,
feeding,
lifespan,
movement,
antioxidation.
This
review
provides
valuable
into
how
influences
processes,
providing
deeper
understanding
complex
roles
underlying
