Neural circuit mechanisms to transform cerebellar population dynamics for motor control in monkeys DOI Creative Commons
David J. Herzfeld, Stephen G. Lisberger

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract We exploit identification of neuron types during extracellular recording to demonstrate how the cerebellar cortex’s well-established architecture transforms inputs into outputs. During smooth pursuit eye movements, floccular complex performs distinct input-output transformations temporal dynamics and directional response properties. The responses different interneuron localize circuit mechanisms each transformation. Mossy fibers unipolar brush cells emphasize position uniformly across cardinal axes; Purkinje molecular layer interneurons code velocity along directionally biased Golgi show unmodulated firing. Differential properties transformation last-order cells. pinpoint site granule Specific cell population allow required in area we study generalize many transformations, providing a complete framework understand computation. Impact statement dissect computations performed by cerebellum an exemplar sensory-motor behavior, taking advantage knowledge architecture, existence discrete types, newfound ability identify from recordings. Our results describe contributions major computations, needed support those create basis set enable temporally-specific motor behavior learning.

Язык: Английский

Characteristics of Cognitive Event-Related Potential Components and N170 Source Analysis in Patients with Acute Cerebellar Infarction DOI

Qirong Ling,

Xiaodong Yuan, Ya Ou

и другие.

The Cerebellum, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 3, 2025

Язык: Английский

Процитировано

0
Toward cognitive models of misophonia DOI Creative Commons
Marie‐Anick Savard, Emily B. J. Coffey

Hearing Research, Год журнала: 2025, Номер unknown, С. 109184 - 109184

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Exploring the Effects of Cerebellar tDCS on Brain Connectivity Using Resting‐State fMRI DOI Creative Commons
Beatriz Catoira, Debora Lombardo, Stefanie De Smet

и другие.

Brain and Behavior, Год журнала: 2025, Номер 15(2)

Опубликована: Фев. 1, 2025

The cerebellum's role extends beyond motor control, impacting various cognitive functions. A growing body of evidence supports the idea that cerebellum optimizes performance across domains, suggesting critical connectivity with neocortex. This study investigates how cerebellar transcranial direct current stimulation (tDCS) targeting right Crus II region modulates functional brain connectivity. Using a within-subject design, 21 healthy participants underwent both sham and anodal tDCS at 2 mA during 20 min concurrent resting-state fMRI sessions. Data was preprocessed, changes were examined using seed-to-voxel analysis. Given potential impact dysfunctions on symptoms associated autism spectrum disorders, we also assessed individual quotient (AQ) scores might influence Moreover, electrical field simulations computed for each participant to explore effects differences. Results indicated increased between inferior frontal gyrus (IFG) active compared stimulation. IFG (part Action Observation Network) plays crucial in understanding actions intentions others, implicating higher-order processes. In addition, linear mixed-effects models revealed an interaction electric strength AQ scores, are based psychobiological Cerebellar significantly altered connectivity, particularly IFG, involved social cognition. These findings contribute our highlighting its processes therapeutic applications, such as disorders.

Язык: Английский

Процитировано

0
Neural circuit mechanisms to transform cerebellar population dynamics for motor control in monkeys DOI Creative Commons
David J. Herzfeld, Stephen G. Lisberger

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract We exploit identification of neuron types during extracellular recording to demonstrate how the cerebellar cortex’s well-established architecture transforms inputs into outputs. During smooth pursuit eye movements, floccular complex performs distinct input-output transformations temporal dynamics and directional response properties. The responses different interneuron localize circuit mechanisms each transformation. Mossy fibers unipolar brush cells emphasize position uniformly across cardinal axes; Purkinje molecular layer interneurons code velocity along directionally biased Golgi show unmodulated firing. Differential properties transformation last-order cells. pinpoint site granule Specific cell population allow required in area we study generalize many transformations, providing a complete framework understand computation. Impact statement dissect computations performed by cerebellum an exemplar sensory-motor behavior, taking advantage knowledge architecture, existence discrete types, newfound ability identify from recordings. Our results describe contributions major computations, needed support those create basis set enable temporally-specific motor behavior learning.

Язык: Английский

Процитировано

0