Association of systemic inflammatory response index with bone mineral density, osteoporosis, and future fracture risk in elderly hypertensive patients

Postgraduate Medicine, Год журнала: 2024, Номер 136(4), С. 406 - 416

Опубликована: Май 16, 2024

This study sought to investigate the relationship between systemic inflammatory response index (SIRI) and bone mineral density (BMD), osteoporosis, future fracture risk in elderly hypertensive patients.

Язык: Английский

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Human Serum Albumin Based Nanodrug Delivery Systems: Recent Advances and Future Perspective

Polymers, Год журнала: 2023, Номер 15(16), С. 3354 - 3354

Опубликована: Авг. 10, 2023

With the success of several clinical trials products based on human serum albumin (HSA) and rapid development nanotechnology, HSA-based nanodrug delivery systems (HBNDSs) have received extensive attention in field nanomedicine. However, there is still a lack comprehensive reviews exploring broader scope HBNDSs biomedical applications beyond cancer therapy. To address this gap, review takes systematic approach. Firstly, it focuses crystal structure potential binding sites HSA. Additionally, provides summary recent progresses for various over past five years, categorized according to type therapeutic drugs loaded onto These categories include small-molecule drugs, inorganic materials bioactive ingredients. Finally, summarizes characteristics current application status drug delivery, also discusses challenges that need be addressed transformation HSA formulations offers future perspectives field.

Язык: Английский

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Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases

Nature Reviews Rheumatology, Год журнала: 2024, Номер 20(7), С. 417 - 431

Опубликована: Июнь 3, 2024

Язык: Английский

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Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

Archives of Pharmacal Research, Год журнала: 2024, Номер 47(4), С. 301 - 324

Опубликована: Апрель 1, 2024

Язык: Английский

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Inflammatory macrophage reprogramming strategy of fucoidan microneedles-mediated ROS-responsive polymers for rheumatoid arthritis

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 271, С. 132442 - 132442

Опубликована: Май 16, 2024

Язык: Английский

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Disease activity of rheumatoid arthritis and kidney function decline: a large prospective registry study

Annals of the Rheumatic Diseases, Год журнала: 2024, Номер 84(2), С. 201 - 209

Опубликована: Авг. 26, 2024

Introduction

Chronic kidney disease (CKD) is a common comorbidity of rheumatoid arthritis (RA). The association longitudinal RA activity with long-term function has remained uncertain.

Method

We analysed multicentre prospective registry in the USA from 2001 to 2022. exposure was updated time-averaged Clinical Disease Activity Index (TA-CDAI) categories study enrolment. primary outcome estimated glomerular filtration rate (eGFR) change. Secondary outcomes included developments CKD stage G3a (eGFR<60 mL/min/1.73 m²) and G3b (eGFR<45 m²). Results were adjusted for relevant time-fixed time-varying covariates.

Results

31 129 patients (median age: 58.0 years, female: 76.3%, median eGFR: 90.7 contributed 234 973 visits 146 778 person-years follow-up. Multivariable mixed-effect linear model showed an average annual eGFR decline during follow-up TA-CDAI-remission group −0.83 m² additional declines (95% CI) –0.09 (–0.15 –0.03) low, –0.17 (−0.23 –0.10) moderate −0.18 (–0.27 –0.08) high patients. Compared TA-CDAI remission, HRs 1.15 (1.01 1.30) 1.22 (1.06 1.40) 1.27 (1.05 1.52) activity; G3b, (0.84 1.76) 1.66 (1.12 2.45) 1.93 (1.16 3.20) activity.

Conclusions

Higher associated accelerated increased risk clinically dysfunction. Future intervention studies should attempt replicate between eGFR.

Язык: Английский

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Relationship between physical function and sarcopenia in the older adults from Amazonas: A cross-sectional study

PLoS ONE, Год журнала: 2025, Номер 20(3), С. e0320079 - e0320079

Опубликована: Март 19, 2025

Physical functioning refers to the ability perform daily living activities, namely basic instrumental, and advanced activities. Poorer performance in these areas may indicate potential presence of sarcopenia. To analyze differences physical function between older people with without sarcopenia investigate associations tests A cross-sectional study based on data from Northern region Brazil year 2018 was conducted. Study participants included 312 aged ≥ 60 years (64.1% female). Sarcopenia defined using updated criteria European Working Group Older People (EWGSOP2). measured functional fitness (30-second chair stand test, sit-and-reach 8-foot Up-and-Go Test, 6-minute walk 4-meter gait speed, Fullerton Advanced Balance Scale). Confirmed detected 29.2% participants, but no participant had severe Most parameters crude analysis were associated confirmed (all p < 0.05), except for back scratch test. In a model adjusted sex, age body mass index, slower speed (OR = 1.29, 95%CI 1.08 1.54), up-and-go test time 1.32, 1.16 1.49), greater 0.97, 0.94 0.99) higher self-reported Composite Function scores 0.94, 0.89 significantly status. EWGSOP2 is prevalent residing Brazil's independently walking rising ability, reduced trunk lower-limb flexibility, as well poorer function.

Язык: Английский

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The interplay of rheumatoid arthritis and osteoporosis: exploring the pathogenesis and pharmacological approaches

Clinical Rheumatology, Год журнала: 2024, Номер 43(5), С. 1421 - 1433

Опубликована: Март 18, 2024

Язык: Английский

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Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Clinical Interventions in Aging, Год журнала: 2024, Номер Volume 19, С. 827 - 841

Опубликована: Май 1, 2024

Abstract: This article focuses on a range of non-pharmacological strategies for managing sarcopenia in chronic diseases, including exercise, dietary supplements, traditional Chinese intestinal microecology, and rehabilitation therapies individuals with limited limb movement. By analyzing multiple studies, the aims to summarize available evidence manage diseases. The results strongly emphasize role resistance training addressing diseases secondary sarcopenia. Maintaining appropriate frequency intensity can help prevent muscle atrophy effectively reduce inflammation. Although aerobic exercise has ability improve skeletal mass, it does have some positive effects physical function. Building upon this, explores potential benefits combined approaches, highlighting their helpfulness overall quality life. Additionally, also highlights importance supplements combating It protein intake, rich essential amino acids omega-3, as well sufficient vitamin D atrophy. Combining appears be an effective strategy preventing sarcopenia, although optimal dosage type supplement remain unclear. Furthermore, microecology Probiotics, prebiotics, bacterial products are suggested new treatment options emerging such whole body vibration training, blood flow restriction, electrical stimulation show promise treating Overall, this provides valuable insights into emphasizes holistic integrated approach that incorporates nutrition, multidisciplinary interventions, which promote health elderly population. Future research should prioritize high-quality randomized controlled trials utilize wearable devices, smartphone applications, other advanced surveillance methods investigate most intervention associated different Keywords: disease, inflammation

Язык: Английский

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Prevalence and risk factors of sarcopenia in patients on maintenance hemodialysis: a retrospective cohort study

BMC Musculoskeletal Disorders, Год журнала: 2024, Номер 25(1)

Опубликована: Май 31, 2024

Abstract Background This study aimed to explore the prevalence and related risk factors of sarcopenia in patients on maintenance hemodialysis (MHD). Methods cohort enrolled 165 MHD. The were divided into non-sarcopenia groups based presence or not. Sarcopenia was diagnosed according consensus Asian Working Group that considers reduced muscle mass decreased strength (19). measured using multi-frequency bioelectrical impedance (Inbody260) skeletal index (SMI) used: <7.0 kg/m 2 (male); <5.7 (female) - with reduction. electronic grip dynamometer used for measuring dominant handgrip (HGS) reflect strength. Male HGS < 28 kg female 18 considered a decrease demographic characteristics, laboratory indexes, anthropometrical measurements, body compositions, InBody score compared between groups. multivariate logistic regression sarcopenia. Results Of MHD, 36 had sarcopenia, 21.82%. Patients group higher ages lower index, serum albumin level, circumference waist, hip, biceps, strength, total water content, protein inorganic salt concentrations, mass, basal metabolic rate, obesity degree, SMI, fat content. showed age, waist circumference, influencing hemodialysis. Conclusion high Higher independent such patients.

Язык: Английский

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