Association of systemic inflammatory response index with bone mineral density, osteoporosis, and future fracture risk in elderly hypertensive patients

Postgraduate Medicine, Journal Year: 2024, Volume and Issue: 136(4), P. 406 - 416

Published: May 16, 2024

This study sought to investigate the relationship between systemic inflammatory response index (SIRI) and bone mineral density (BMD), osteoporosis, future fracture risk in elderly hypertensive patients.

Language: Английский

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Human Serum Albumin Based Nanodrug Delivery Systems: Recent Advances and Future Perspective

Polymers, Journal Year: 2023, Volume and Issue: 15(16), P. 3354 - 3354

Published: Aug. 10, 2023

With the success of several clinical trials products based on human serum albumin (HSA) and rapid development nanotechnology, HSA-based nanodrug delivery systems (HBNDSs) have received extensive attention in field nanomedicine. However, there is still a lack comprehensive reviews exploring broader scope HBNDSs biomedical applications beyond cancer therapy. To address this gap, review takes systematic approach. Firstly, it focuses crystal structure potential binding sites HSA. Additionally, provides summary recent progresses for various over past five years, categorized according to type therapeutic drugs loaded onto These categories include small-molecule drugs, inorganic materials bioactive ingredients. Finally, summarizes characteristics current application status drug delivery, also discusses challenges that need be addressed transformation HSA formulations offers future perspectives field.

Language: Английский

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Osteoporosis and fracture risk are multifactorial in patients with inflammatory rheumatic diseases

Nature Reviews Rheumatology, Journal Year: 2024, Volume and Issue: 20(7), P. 417 - 431

Published: June 3, 2024

Language: Английский

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Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies

Archives of Pharmacal Research, Journal Year: 2024, Volume and Issue: 47(4), P. 301 - 324

Published: April 1, 2024

Language: Английский

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Inflammatory macrophage reprogramming strategy of fucoidan microneedles-mediated ROS-responsive polymers for rheumatoid arthritis

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 271, P. 132442 - 132442

Published: May 16, 2024

Language: Английский

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The interplay of rheumatoid arthritis and osteoporosis: exploring the pathogenesis and pharmacological approaches

Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(5), P. 1421 - 1433

Published: March 18, 2024

Language: Английский

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Disease activity of rheumatoid arthritis and kidney function decline: a large prospective registry study

Annals of the Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 84(2), P. 201 - 209

Published: Aug. 26, 2024

Introduction

Chronic kidney disease (CKD) is a common comorbidity of rheumatoid arthritis (RA). The association longitudinal RA activity with long-term function has remained uncertain.

Method

We analysed multicentre prospective registry in the USA from 2001 to 2022. exposure was updated time-averaged Clinical Disease Activity Index (TA-CDAI) categories study enrolment. primary outcome estimated glomerular filtration rate (eGFR) change. Secondary outcomes included developments CKD stage G3a (eGFR<60 mL/min/1.73 m²) and G3b (eGFR<45 m²). Results were adjusted for relevant time-fixed time-varying covariates.

Results

31 129 patients (median age: 58.0 years, female: 76.3%, median eGFR: 90.7 contributed 234 973 visits 146 778 person-years follow-up. Multivariable mixed-effect linear model showed an average annual eGFR decline during follow-up TA-CDAI-remission group −0.83 m² additional declines (95% CI) –0.09 (–0.15 –0.03) low, –0.17 (−0.23 –0.10) moderate −0.18 (–0.27 –0.08) high patients. Compared TA-CDAI remission, HRs 1.15 (1.01 1.30) 1.22 (1.06 1.40) 1.27 (1.05 1.52) activity; G3b, (0.84 1.76) 1.66 (1.12 2.45) 1.93 (1.16 3.20) activity.

Conclusions

Higher associated accelerated increased risk clinically dysfunction. Future intervention studies should attempt replicate between eGFR.

Language: Английский

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Molecular crosstalk and potential causal mechanisms of rheumatoid arthritis and sarcopenia co-morbidity: A gene integration analysis

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 203, P. 112729 - 112729

Published: March 11, 2025

Rheumatoid arthritis (RA) promotes the onset and progression of sarcopenia, yet mechanisms co-morbidity between RA sarcopenia are under-explored. Therefore, this study integrated Gene Expression Omnibus (GEO) Genome-wide association studies (GWAS) data to comprehensively identify shared genes, associated mechanisms, biological pathways in sarcopenia. Utilizing two GEO datasets-GSE226151, which includes 60 RNA-seq samples skeletal muscle from healthy aged, pre-sarcopenia, individuals, GSE55235, with 20 synovial tissue joints-we performed differentially expressed genes analysis, weighted gene co-expression network analysis crosstalk enrichment for these genes. Using relevant GWAS datasets, SMR analyses cis-eQTL were performed. We further validated identified key explored potential causal associations sarcopenia-related traits. 25 involved immune-inflammatory response pathways, including neutrophil extracellular trap formation Fc gamma receptor-mediated phagocytosis. six core genes: NCF1, FCGR2A, FCGR3A, SORL1, FCGR3B, ITGAX (PSMR < 0.05). showed that FCGR2A might have a negative appendicular lean mass, whole body fat-free positive (P Overall, is first reveal molecular identifying response-related pathways. Further conducted validate emerging as drug target RA-associated These findings provide new insights into comorbid offering therapeutic targets both conditions.

Language: Английский

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Relationship between physical function and sarcopenia in the older adults from Amazonas: A cross-sectional study

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(3), P. e0320079 - e0320079

Published: March 19, 2025

Physical functioning refers to the ability perform daily living activities, namely basic instrumental, and advanced activities. Poorer performance in these areas may indicate potential presence of sarcopenia. To analyze differences physical function between older people with without sarcopenia investigate associations tests A cross-sectional study based on data from Northern region Brazil year 2018 was conducted. Study participants included 312 aged ≥ 60 years (64.1% female). Sarcopenia defined using updated criteria European Working Group Older People (EWGSOP2). measured functional fitness (30-second chair stand test, sit-and-reach 8-foot Up-and-Go Test, 6-minute walk 4-meter gait speed, Fullerton Advanced Balance Scale). Confirmed detected 29.2% participants, but no participant had severe Most parameters crude analysis were associated confirmed (all p < 0.05), except for back scratch test. In a model adjusted sex, age body mass index, slower speed (OR = 1.29, 95%CI 1.08 1.54), up-and-go test time 1.32, 1.16 1.49), greater 0.97, 0.94 0.99) higher self-reported Composite Function scores 0.94, 0.89 significantly status. EWGSOP2 is prevalent residing Brazil's independently walking rising ability, reduced trunk lower-limb flexibility, as well poorer function.

Language: Английский

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Inflammatory profile in patients with rheumatoid arthritis and sarcopenia

Clinical Rheumatology, Journal Year: 2024, Volume and Issue: 43(6), P. 1865 - 1870

Published: April 26, 2024

Language: Английский

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