Novel Thioxothiazolo[3,4-a]quinazolin-5(4H)-one Derivatives as BKCa Channel Activators for Urinary Incontinence DOI
Eun Jung Bae,

Heeji Jo,

Seong Soon Kim

и другие.

ACS Medicinal Chemistry Letters, Год журнала: 2022, Номер 13(7), С. 1052 - 1061

Опубликована: Июнь 21, 2022

Overactive bladder (OAB) is a syndrome causing sudden and unstoppable need to urinate with significant global prevalence. Several drugs are used treat OAB; however, they have various side effects. Therefore, new treatment options for OAB required. A series of novel 5-oxo-N-phenyl-1-thioxo-4,5-dihydro-1H-thiazolo[3,4-a]quinazoline-3-carboxamide derivatives were synthesized evaluated their large-conductance voltage- Ca2+-activated K+ channel activation through cell-based fluorescence assay electrophysiological recordings. compounds, including 7-bromo substituent on the heterocyclic system, showed increased currents. Among derivatives, compound 12h exhibited potent in vitro activity half-maximal effective concentration (EC50) 2.89 μM, good oral pharmacokinetic properties (area under curve half-life), vivo efficacy spontaneously hypertensive rat model.

Язык: Английский

Symptomatic Care in Multiple System Atrophy: State of the Art DOI Creative Commons
Anna Grossauer, Victoria Sidoroff, Beatrice Heim

и другие.

The Cerebellum, Год журнала: 2022, Номер 22(3), С. 433 - 446

Опубликована: Май 17, 2022

Abstract Without any disease-modifying treatment strategy for multiple system atrophy (MSA), the therapeutic management of MSA patients focuses on a multidisciplinary symptom control. In present review, we will focus state art in and additionally give short overview about ongoing randomized controlled trials this field.

Язык: Английский

Процитировано

9
Prescribing cascades: how to detect them, prevent them, and use them appropriately DOI
Tobias Dreischulte,

Faiza Shahid,

Christiane Muth

и другие.

Deutsches Ärzteblatt international, Год журнала: 2022, Номер unknown

Опубликована: Окт. 25, 2022

A prescribing cascade is the treatment of an adverse drug reaction (ADR) with another drug. In this review, we discuss (a) different types and (b) measures that can be taken so they will recognized dealt appropriately, both in hospital outpatient setting.

Язык: Английский

Процитировано

9
The Impact of Anticholinergic Use for Overactive Bladder on Cognitive Changes in Adults with Normal Cognition, Mild Cognitive Impairment, or Dementia DOI
Blayne Welk,

J. Andrew McClure

European Urology Open Science, Год журнала: 2022, Номер 46, С. 22 - 29

Опубликована: Окт. 25, 2022

Язык: Английский

Процитировано

9
Treating Lower Urinary Tract Symptoms in Older Adults: Intravesical Options DOI

Anirban Ganguly,

Shachi Tyagi, Christopher Chermansky

и другие.

Drugs & Aging, Год журнала: 2023, Номер 40(3), С. 241 - 261

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

5
Urinary dysfunction in patients with vascular cognitive impairment DOI Creative Commons
Panpan Zhao, Guimei Zhang, Yanxin Shen

и другие.

Frontiers in Aging Neuroscience, Год журнала: 2023, Номер 14

Опубликована: Янв. 18, 2023

Vascular cognitive impairment (VCI) is caused by vascular pathologies, with the spectrum of disorders ranging from subjective dysfunction to dementia. Particularly among older adults, often complicated urinary (UD); some patients may present UD before owing stroke or even when there are white matter hyperintensities on imaging studies. Patients have both language and movement dysfunction, thus, in VCI can be underdiagnosed remain untreated. has an impact quality life caregivers, leading poor outcomes. Medical history important aspect should taken their caregivers. Clinical assessment including urinalysis, voiding diary, scales impairment, post-void residual volume measurement, uroflowmetry, (video-) urodynamics performed according indication. Although studies few, most them show that overactive bladder (OAB) common type, incontinence symptom. Normal urine storage micturition a specific environment complex processes require sophisticated neural network. many brain–urinary circuit, circuit involving remains unclear. Currently, no disease-modifying pharmacological treatment for anti-acetylcholine drugs, which commonly used treat OAB, cause vicious circle. Therefore, it understand interaction between formulate individualized plans. This review provides overview research advances clinical features, pathological characteristics, options increase subject awareness, facilitate research, improve diagnosis rates.

Язык: Английский

Процитировано

4
Lower urinary tract dysfunction in the central nervous system neurogenic bladder and the real-life treatment outcome of botulinum toxin A DOI Creative Commons

Hann-Chorng Kuo

Tzu Chi Medical Journal, Год журнала: 2024, Номер 36(3), С. 260 - 270

Опубликована: Май 24, 2024

A BSTRACT Neurogenic lower urinary tract dysfunction (NLUTD) is common in patients with central nervous system (CNS) lesions. Cases of cerebrovascular accidents (CVA), Parkinson’s disease, dementia, and other intracranial lesions develop poor bladder control or without difficulty due to loss cortical perception filling sensation coordination urethral sphincter relaxation during reflex micturition. Patients CNS usually have overactive (OAB) symptoms, including urgency, frequency, incontinence, voiding symptoms dysuria, large postvoid residual volume, retention. In elderly severe disease the OAB are difficult adequately relieve by medical treatment, thus, their quality life greatly. Botulinum toxin (BoNT-A) currently licensed has been applied idiopathic neurogenic spinal cord injury multiple sclerosis. However, application BoNT-A treatment incontinence NLUTD chronic not well-documented. Although cohort studies case series support for OAB, urine retention after intravesical injection exacerbated greatly limited its among This article reviews pathophysiology clinical characteristics effects adverse events NLUTD. flowchart was created outline patient selection strategy OAB.

Язык: Английский

Процитировано

1
Risk of dementia associated with the use of anticholinergic medications: a review of recent literature DOI

Hachem Ziadeh,

Stephen Rhodes, David Sheyn

и другие.

Current Opinion in Urology, Год журнала: 2024, Номер 34(6), С. 444 - 451

Опубликована: Авг. 14, 2024

Purpose of review While there is an established association between the use anticholinergic medications and its effects on cognition, extent this impact remains unclear. We outline recent studies addressing topic. Recent findings describe a series articles discussing risk dementia associated with medication in general, further focus overactive bladder (OAB) use, detailing short & long-term effects, variation based age gender, reporting alternative treatment options. Summary Anticholinergic bears increased development, accelerated cognitive decline individuals preexisting dementia, being related to dosages, length exposure, pharmacological profile. β3-adrenoceptor agonists have proven be potent for OAB anticholinergics, owing safe profile regards no clear function, having similar efficacy treatment.

Язык: Английский

Процитировано

1
The Differential Risk of Mortality Among Users of Overactive Bladder Anticholinergic Medications and β3 Agonists DOI
Blayne Welk

European Urology Focus, Год журнала: 2022, Номер 9(1), С. 168 - 171

Опубликована: Авг. 17, 2022

Язык: Английский

Процитировано

7
Evidence-Informed, Interdisciplinary, Multidimensional Action Plan to Advance Overactive Bladder Research and Treatment Initiatives: Directives From State-of-the-Science Conference on Overactive Bladder and Cognitive Impairment DOI
Tatiana V. D. Sanses, Jacqueline Zillioux, Rachel High

и другие.

Urogynecology, Год журнала: 2022, Номер 29(1S), С. S20 - S39

Опубликована: Окт. 21, 2022

This article outlines an evidence-informed, interdisciplinary, multidimensional, comprehensive action plan for the American Urogynecologic Society to improve care of women with overactive bladder (OAB) while minimizing treatment-related adverse events, including cognitive impairment. It is a "call action" advance basic, translational, and clinical research summarizes initiatives developed at State-of-the-Science Conference on OAB Cognitive Impairment (1) develop framework new treatment approach in women, (2) define gaps future priorities, (3) champion health equity diversity considerations treatment, (4) foster community promote education remove stigma surrounding urinary incontinence, (5) elevate visibility impact OAB, by creating partnerships through engagement professionals, industry, private public payers, funding agencies, policymakers.

Язык: Английский

Процитировано

7
Therapeutic efficacy and cognitive adverse events of overactive bladder medication in patients with central nervous system Disorders—A cohort study DOI Creative Commons
Sheng‐Fu Chen, Yao‐Chi Chuang, Chung‐Cheng Wang

и другие.

Journal of the Formosan Medical Association, Год журнала: 2022, Номер 121(10), С. 2101 - 2108

Опубликована: Апрель 18, 2022

This cohort study evaluates therapeutic efficacy and adverse events (AEs) of various overactive bladder (OAB) medications for patients with central nervous system (CNS) disorders.Patients OAB CNS disorders were prospectively enrolled. They randomly allocated to 3 different treatment subgroups: (1) mirabegron 50 mg once daily (2) solifenacin 5 per day, (3) combined daily. Efficacy safety questionnaires objective parameters compared among the subgroups, subgroups between baseline 6 months after treatment. AEs, including cognitive dysfunction, assessed using Mini-Mental State Examination (MMSE).102 (mean age, 71.8 ± 8.7 years) enrolled, 35, 36, 31 received monotherapy, combination therapy, respectively. symptoms scores all significantly improved in subgroup. However, PVR increased VE decreased receiving monotherapy therapy. Dry mouth constipation most common especially subgroups. Mild incidence AEs was noted monotherapy. No significant change MMSE treatment.OAB medication had good who disorders, cerebrovascular accident parkinsonism. or their affected function, whereas minimal mirabegron. Mirabegron could be recommended as first choice managing these patients.

Язык: Английский

Процитировано

5