Feelings
of
hunger
and
satiety
are
the
key
determinants
for
maintaining
life
humans
animals.
Disturbed
appetite
control
may
disrupt
metabolic
health
host
cause
various
disorders.
A
variety
factors
have
been
implicated
in
control,
including
gut
microbiota,
which
develop
intricate
interactions
to
manipulate
requirements
hedonic
feelings.
Gut
microbial
metabolites
components
act
as
appetite-related
signaling
molecules
regulate
hormone
secretion
immune
system,
or
directly
on
hypothalamic
neurons.
Herein,
we
summarize
effects
microbiota
consider
potential
molecular
mechanisms.
Furthermore,
propose
that
manipulation
represents
a
clinical
therapeutic
lessening
development
consequence
Video
abstract.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Янв. 3, 2020
Abstract
Mitochondria
are
signaling
organelles
that
regulate
a
wide
variety
of
cellular
functions
and
can
dictate
cell
fate.
Multiple
mechanisms
contribute
to
communicate
mitochondrial
fitness
the
rest
cell.
Recent
evidence
confers
new
role
for
TCA
cycle
intermediates,
generally
thought
be
important
biosynthetic
purposes,
as
molecules
with
controlling
chromatin
modifications,
DNA
methylation,
hypoxic
response,
immunity.
This
review
summarizes
by
which
abundance
different
metabolites
controls
function
fate
in
contexts.
We
will
focus
on
how
these
mediated
affect
physiology
disease.
Physiological Reviews,
Год журнала:
2019,
Номер
99(4), С. 1819 - 1875
Опубликована: Авг. 22, 2019
Metabolomics
uses
advanced
analytical
chemistry
techniques
to
enable
the
high-throughput
characterization
of
metabolites
from
cells,
organs,
tissues,
or
biofluids.
The
rapid
growth
in
metabolomics
is
leading
a
renewed
interest
metabolism
and
role
that
small
molecule
play
many
biological
processes.
As
result,
traditional
views
as
being
simply
“bricks
mortar”
cells
just
fuel
for
cellular
energetics
are
upended.
Indeed,
appear
have
much
more
varied
far
important
roles
signaling
molecules,
immune
modulators,
endogenous
toxins,
environmental
sensors.
This
review
explores
how
yielding
new
insights
into
number
physiological
In
particular,
major
focus
on
illustrating
discoveries
made
through
improving
our
understanding
both
normal
physiology
pathophysiology
diseases.
These
influence
organ
function,
nutrient
sensing,
gut
physiology.
Collectively,
this
work
unified
system-wide
perspective
biology
wherein
metabolites,
proteins,
genes
understood
interact
synergistically
modify
actions
functions
organelles,
organisms.
