
Mitochondrion, Год журнала: 2023, Номер 70, С. 59 - 102
Опубликована: Март 1, 2023
Язык: Английский
Mitochondrion, Год журнала: 2023, Номер 70, С. 59 - 102
Опубликована: Март 1, 2023
Язык: Английский
Cancer Cell, Год журнала: 2023, Номер 41(3), С. 374 - 403
Опубликована: Март 1, 2023
Язык: Английский
Процитировано
1539Cell, Год журнала: 2023, Номер 186(8), С. 1564 - 1579
Опубликована: Апрель 1, 2023
Язык: Английский
Процитировано
357Nature Reviews Drug Discovery, Год журнала: 2023, Номер 22(6), С. 496 - 520
Опубликована: Апрель 28, 2023
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods, together with associated computational tools and the growing availability of public data resources, are transforming drug discovery development. New opportunities emerging in target identification owing to improved disease understanding through cell subtyping, highly multiplexed functional genomics screens incorporating scRNA-seq enhancing credentialling prioritization. ScRNA-seq is also aiding selection relevant preclinical models providing new insights into mechanisms action. In clinical development, can inform decision-making via biomarker for patient stratification more precise monitoring response progression. Here, we illustrate how methods being applied key steps discuss ongoing challenges their implementation pharmaceutical industry. There have been significant recent advances development remarkable Ferran colleagues primarily pipeline, from decision-making. Ongoing potential future directions discussed.
Язык: Английский
Процитировано
199Nature reviews. Cancer, Год журнала: 2022, Номер 23(2), С. 95 - 111
Опубликована: Дек. 9, 2022
Язык: Английский
Процитировано
171Cell, Год журнала: 2024, Номер 187(7), С. 1589 - 1616
Опубликована: Март 1, 2024
Язык: Английский
Процитировано
161Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(7), С. 487 - 500
Опубликована: Июнь 2, 2023
Язык: Английский
Процитировано
159Cancer Cell, Год журнала: 2023, Номер 41(3), С. 505 - 526
Опубликована: Фев. 23, 2023
Язык: Английский
Процитировано
139Nature Reviews Genetics, Год журнала: 2022, Номер 24(5), С. 295 - 313
Опубликована: Дек. 9, 2022
Язык: Английский
Процитировано
119Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)
Опубликована: Дек. 21, 2023
Organ-specific metastasis is the primary cause of cancer patient death. The distant tumor cells to specific organs depends on both intrinsic characteristics and extrinsic factors in their microenvironment. During an intermediate stage metastasis, circulating (CTCs) are released into bloodstream from metastatic tumors. CTCs harboring aggressive or features can extravasate remote sites for continuous colonizing growth, leading further lesions. In past decade, numerous studies demonstrated that exhibited huge clinical value including predicting assessing prognosis monitoring treatment response et al. Furthermore, increasingly experiments dedicated identifying key molecules inside exploring how they mediate CTC-related organ-specific metastasis. Based above molecules, more inhibitors being developed target utilized completely clean CTCs, which should provide promising prospects administer advanced tumor. Recently, application various nanomaterials microfluidic technologies enrichment technology has assisted improve our deep insights phenotypic biological functions as a potential therapy target, may pave way us make practical strategies. present review, we mainly focus role involved targeted organ especially latest molecular mechanism research intervention strategies related CTCs.
Язык: Английский
Процитировано
54Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)
Опубликована: Апрель 13, 2023
Abstract The advent of immunotherapy has made an indelible mark on the field cancer therapy, especially application immune checkpoint inhibitors in clinical practice. Although proven its efficacy and safety some tumors, many patients still have innate or acquired resistance to immunotherapy. emergence this phenomenon is closely related highly heterogeneous microenvironment formed by tumor cells after undergoing immunoediting. process immunoediting refers cooperative interaction between system that involves three phases: elimination, equilibrium, escape. During these phases, conflicting interactions result formation a complex microenvironment, which contributes acquisition different levels cells. In review, we summarize characteristics phases corresponding therapeutic tools, propose normalized strategies based immunophenotyping. retrograded through targeted interventions immunoediting, making context precision therapy most promising cure cancer.
Язык: Английский
Процитировано
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