The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat DOI Creative Commons
Peter W. Stacpoole, Charles E. McCall

Mitochondrion, Год журнала: 2023, Номер 70, С. 59 - 102

Опубликована: Март 1, 2023

Язык: Английский

The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth DOI Creative Commons
Karin E. de Visser, Johanna A. Joyce

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 374 - 403

Опубликована: Март 1, 2023

Язык: Английский

Процитировано

1539

Metastasis DOI Creative Commons

Stefanie Gerstberger,

Qingwen Jiang, Karuna Ganesh

и другие.

Cell, Год журнала: 2023, Номер 186(8), С. 1564 - 1579

Опубликована: Апрель 1, 2023

Язык: Английский

Процитировано

357

Applications of single-cell RNA sequencing in drug discovery and development DOI Creative Commons
Bram Van de Sande, Joon Sang Lee, Euphemia Mutasa-Gottgens

и другие.

Nature Reviews Drug Discovery, Год журнала: 2023, Номер 22(6), С. 496 - 520

Опубликована: Апрель 28, 2023

Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods, together with associated computational tools and the growing availability of public data resources, are transforming drug discovery development. New opportunities emerging in target identification owing to improved disease understanding through cell subtyping, highly multiplexed functional genomics screens incorporating scRNA-seq enhancing credentialling prioritization. ScRNA-seq is also aiding selection relevant preclinical models providing new insights into mechanisms action. In clinical development, can inform decision-making via biomarker for patient stratification more precise monitoring response progression. Here, we illustrate how methods being applied key steps discuss ongoing challenges their implementation pharmaceutical industry. There have been significant recent advances development remarkable Ferran colleagues primarily pipeline, from decision-making. Ongoing potential future directions discussed.

Язык: Английский

Процитировано

199

Biology, vulnerabilities and clinical applications of circulating tumour cells DOI Open Access
Alexander Ring, Bich Doan Nguyen-Sträuli, Andreas Wicki

и другие.

Nature reviews. Cancer, Год журнала: 2022, Номер 23(2), С. 95 - 111

Опубликована: Дек. 9, 2022

Язык: Английский

Процитировано

171

Embracing cancer complexity: Hallmarks of systemic disease DOI Open Access
Charles Swanton, Elsa Bernard,

Chris Abbosh

и другие.

Cell, Год журнала: 2024, Номер 187(7), С. 1589 - 1616

Опубликована: Март 1, 2024

Язык: Английский

Процитировано

161

Circulating tumour cells for early detection of clinically relevant cancer DOI Open Access
Rachel Lawrence,

Melissa Watters,

Caitlin R. Davies

и другие.

Nature Reviews Clinical Oncology, Год журнала: 2023, Номер 20(7), С. 487 - 500

Опубликована: Июнь 2, 2023

Язык: Английский

Процитировано

159

NETworking with cancer: The bidirectional interplay between cancer and neutrophil extracellular traps DOI Creative Commons
José M. Adrover, Sheri A. C. McDowell, Xue‐Yan He

и другие.

Cancer Cell, Год журнала: 2023, Номер 41(3), С. 505 - 526

Опубликована: Фев. 23, 2023

Язык: Английский

Процитировано

139

Spatial biology of cancer evolution DOI
Zaira Seferbekova, Artem Lomakin, Lucy Yates

и другие.

Nature Reviews Genetics, Год журнала: 2022, Номер 24(5), С. 295 - 313

Опубликована: Дек. 9, 2022

Язык: Английский

Процитировано

119

New insights into the correlations between circulating tumor cells and target organ metastasis DOI Creative Commons

Qinru Zhan,

Bixia Liu,

Xiaohua Situ

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Дек. 21, 2023

Organ-specific metastasis is the primary cause of cancer patient death. The distant tumor cells to specific organs depends on both intrinsic characteristics and extrinsic factors in their microenvironment. During an intermediate stage metastasis, circulating (CTCs) are released into bloodstream from metastatic tumors. CTCs harboring aggressive or features can extravasate remote sites for continuous colonizing growth, leading further lesions. In past decade, numerous studies demonstrated that exhibited huge clinical value including predicting assessing prognosis monitoring treatment response et al. Furthermore, increasingly experiments dedicated identifying key molecules inside exploring how they mediate CTC-related organ-specific metastasis. Based above molecules, more inhibitors being developed target utilized completely clean CTCs, which should provide promising prospects administer advanced tumor. Recently, application various nanomaterials microfluidic technologies enrichment technology has assisted improve our deep insights phenotypic biological functions as a potential therapy target, may pave way us make practical strategies. present review, we mainly focus role involved targeted organ especially latest molecular mechanism research intervention strategies related CTCs.

Язык: Английский

Процитировано

54

Novel strategies for cancer immunotherapy: counter-immunoediting therapy DOI Creative Commons
Shaochuan Liu, Qian Sun,

Xiubao Ren

и другие.

Journal of Hematology & Oncology, Год журнала: 2023, Номер 16(1)

Опубликована: Апрель 13, 2023

Abstract The advent of immunotherapy has made an indelible mark on the field cancer therapy, especially application immune checkpoint inhibitors in clinical practice. Although proven its efficacy and safety some tumors, many patients still have innate or acquired resistance to immunotherapy. emergence this phenomenon is closely related highly heterogeneous microenvironment formed by tumor cells after undergoing immunoediting. process immunoediting refers cooperative interaction between system that involves three phases: elimination, equilibrium, escape. During these phases, conflicting interactions result formation a complex microenvironment, which contributes acquisition different levels cells. In review, we summarize characteristics phases corresponding therapeutic tools, propose normalized strategies based immunophenotyping. retrograded through targeted interventions immunoediting, making context precision therapy most promising cure cancer.

Язык: Английский

Процитировано

49