Advanced Materials,
Год журнала:
2024,
Номер
36(31)
Опубликована: Апрель 18, 2024
Abstract
Peritoneal
metastasis
(PM)
is
considered
one
of
the
most
dreaded
forms
cancer
metastases
for
both
patients
and
physicians.
Aggressive
cytoreductive
surgery
(CRS)
primary
treatment
peritoneal
metastasis.
Unfortunately,
this
intensive
frequently
causes
clinical
complications,
such
as
postoperative
recurrence,
metastasis,
adhesion
formation.
Emerging
evidence
suggests
that
neutrophil
extracellular
traps
(NETs)
released
by
inflammatory
neutrophils
contribute
to
these
complications.
Effective
NET‐targeting
strategies
thus
show
considerable
potential
in
counteracting
complications
but
remain
challenging.
Here,
type
sulfoxide‐containing
homopolymer,
PMeSEA,
with
potent
fouling‐resistant
NET‐inhibiting
capabilities,
synthesized
screened.
Hydrating
sulfoxide
groups
endow
PMeSEA
superior
nonfouling
ability,
significantly
inhibiting
protein/cell
adhesion.
Besides,
polysulfoxides
can
be
selectively
oxidized
ClO
−
which
required
stabilize
NETs
rather
than
H
2
O
,
scavenging
effectively
inhibits
formation
without
disturbing
redox
homeostasis
tumor
cells
quiescent
neutrophils.
As
a
result,
potently
prevents
adhesions,
suppresses
shows
synergetic
antitumor
activity
chemotherapeutic
5‐Fluorouracil.
Moreover,
coupling
CRS
CRS‐induced
metastatic
relapse
adhesions.
Notably,
exhibits
low
vivo
acute
subacute
toxicities,
implying
significant
adjuvant
treatment.
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Июль 31, 2023
Abstract
Cellular
mechanotransduction,
a
critical
regulator
of
numerous
biological
processes,
is
the
conversion
from
mechanical
signals
to
biochemical
regarding
cell
activities
and
metabolism.
Typical
cues
in
organisms
include
hydrostatic
pressure,
fluid
shear
stress,
tensile
force,
extracellular
matrix
stiffness
or
tissue
elasticity,
viscosity.
Mechanotransduction
has
been
expected
trigger
multiple
such
as
embryonic
development,
repair
regeneration.
However,
prolonged
excessive
stimulation
can
result
pathological
multi-organ
fibrosis,
tumorigenesis,
cancer
immunotherapy
resistance.
Although
associations
between
normal
homeostasis
diseases
have
identified,
regulatory
mechanisms
among
different
are
not
yet
comprehensively
illustrated,
no
effective
therapies
currently
available
targeting
cue-related
signaling.
This
review
systematically
summarizes
characteristics
typical
conditions
with
updated
evidence.
The
key
effectors
responding
stimulations
listed,
Piezo
channels,
integrins,
Yes-associated
protein
(YAP)
/transcriptional
coactivator
PDZ-binding
motif
(TAZ),
transient
receptor
potential
vanilloid
4
(TRPV4).
We
also
reviewed
signaling
pathways,
therapeutic
targets
cutting-edge
clinical
applications
related
cues.
Chemical Reviews,
Год журнала:
2023,
Номер
123(18), С. 10920 - 10989
Опубликована: Сен. 15, 2023
Anticancer
nanomedicines
have
been
proven
effective
in
mitigating
the
side
effects
of
chemotherapeutic
drugs.
However,
challenges
remain
augmenting
their
therapeutic
efficacy.
Nanomedicines
responsive
to
pathological
abnormalities
tumor
microenvironment
(TME)
are
expected
overcome
biological
limitations
conventional
nanomedicines,
enhance
efficacies,
and
further
reduce
effects.
This
Review
aims
quantitate
various
TME,
which
may
serve
as
unique
endogenous
stimuli
for
design
stimuli-responsive
provide
a
broad
objective
perspective
on
current
understanding
cancer
treatment.
We
dissect
typical
transport
process
barriers
drug
delivery,
highlight
key
principles
designed
tackle
series
delivery
process,
discuss
"all-into-one"
"one-for-all"
strategies
integrating
needed
properties
nanomedicines.
Ultimately,
we
insight
into
future
perspectives
toward
clinical
translation
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
62(20)
Опубликована: Фев. 3, 2023
Flipper
probes
have
been
introduced
as
small
molecule
fluorophores
to
image
physical
forces,
that
is,
membrane
tension
in
living
systems.
Their
emergence
over
one
decade
is
described,
from
evolution
design
and
synthesis
spectroscopic
properties.
Responsiveness
compression
equilibrium
at
the
ground
state
identified
ideal
origin
of
mechanosensitivity
cells.
A
rich
collection
flippers
described
deliver
release
any
subcellular
interest
a
leaflet-specific
manner.
Chalcogen-bonding
cascade
switching
dynamic
covalent
are
developed
for
super-resolution
imaging
dual-sensing
hydration.
Availability
broad
use
community
validate
flipper
fine
example
power
translational
supramolecular
chemistry,
moving
fundamental
principles
success
on
market.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Июнь 23, 2023
Abstract
Crosstalk
between
ion
channels
and
small
GTPases
is
critical
during
homeostasis
disease,
but
little
known
about
the
structural
underpinnings
of
these
interactions.
TRPV4
a
polymodal,
calcium-permeable
cation
channel
that
has
emerged
as
potential
therapeutic
target
in
multiple
conditions.
Gain-of-function
mutations
also
cause
hereditary
neuromuscular
disease.
Here,
we
present
cryo-EM
structures
human
complex
with
RhoA
ligand-free,
antagonist-bound
closed,
agonist-bound
open
states.
These
reveal
mechanism
ligand-dependent
gating.
Channel
activation
associated
rigid-body
rotation
intracellular
ankyrin
repeat
domain,
state-dependent
interaction
membrane-anchored
constrains
this
movement.
Notably,
many
residues
at
TRPV4-RhoA
interface
are
mutated
disease
perturbing
by
introducing
into
either
or
increases
activity.
Together,
results
suggest
serves
an
auxiliary
subunit
for
TRPV4,
regulating
TRPV4-mediated
calcium
disruption
interactions
can
lead
to
TRPV4-related
insights
will
help
facilitate
therapeutics
development.
Angewandte Chemie International Edition,
Год журнала:
2023,
Номер
63(6)
Опубликована: Окт. 19, 2023
Abstract
The
viscosity
and
crowding
of
biological
environment
are
considered
vital
for
the
correct
cellular
function,
alterations
in
these
parameters
known
to
underly
a
number
pathologies
including
diabetes,
malaria,
cancer
neurodegenerative
diseases,
name
few.
Over
last
decades,
fluorescent
molecular
probes
termed
rotors
proved
extremely
useful
exploring
viscosity,
crowding,
underlying
interactions
biologically
relevant
settings.
In
this
review,
we
will
discuss
basic
principles
underpinning
functionality
review
advances
their
use
as
sensors
lipid
order,
protein
conformation,
temperature
non‐canonical
nucleic
acid
structures
live
cells
other
