Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
ACS Nano,
Год журнала:
2023,
Номер
17(17), С. 16770 - 16786
Опубликована: Авг. 25, 2023
Paclitaxel
(PTX)-based
chemotherapy
remains
the
main
approach
to
treating
lung
cancer
but
systemic
toxicity
limits
its
use.
As
chimeric
antigen
receptor-T
(CAR-T)
cell-derived
exosomes
contain
tumor-targeted
CARs
and
cytotoxic
granules
(granzyme
B
perforin),
they
are
considered
potential
delivery
vehicles
for
PTX.
However,
low
drug-loading
capacity
hepatotropic
properties
of
obstacles
their
application
extrahepatic
cancer.
Here,
a
hybrid
nanovesicle
named
Lip-CExo@PTX
was
designed
immunochemotherapy
by
fusing
derived
from
bispecific
CAR-T
cells
targeting
both
mesothelin
(MSLN)
programmed
death
ligand-1
(PD-L1)
with
lung-targeted
liposomes.
Due
lung-targeting
ability
liposomes,
over
95%
intravenously
administered
accumulated
in
tissue.
In
addition,
help
anti-MSLN
single-chain
variable
fragment
(scFv),
PTX
inside
were
further
delivered
into
MSLN-positive
tumors.
Notably,
anti-PD-L1
scFv
on
blocked
PD-L1
tumors
avoid
T
cell
exhaustion
promoted
PTX-induced
immunogenic
death.
Furthermore,
prolonged
survival
time
tumor-bearing
mice
CT-26
metastatic
model.
Therefore,
may
deliver
tumor
through
sequential
targeted
enhance
antitumor
effects,
providing
promising
strategy
Abstract
Sonodynamic
therapy
(SDT)
as
a
promising
non‐invasive
anti‐tumor
means
features
the
preferable
penetration
depth,
which
nevertheless,
usually
can't
work
without
sonosensitizers.
Sonosensitizers
produce
reactive
oxygen
species
(ROS)
in
presence
of
ultrasound
to
directly
kill
tumor
cells,
and
concurrently
activate
immunity
especially
after
integration
with
microenvironment
(TME)‐engineered
nanobiotechnologies
combined
therapy.
Current
sonosensitizers
are
classified
into
organic
inorganic
ones,
current
most
reviews
only
cover
highlighted
their
applications.
However,
there
have
few
specific
that
focus
on
including
design
principles,
regulation,
etc.
In
this
review,
first
according
rationales
rather
than
composition,
action
underlying
chemistry
highlighted.
Afterward,
what
how
TME
is
regulated
based
sonosensitizers‐based
SDT
nanoplatform
an
emphasis
targets‐engineered
elucidated.
Additionally,
applications
non‐cancer
diseases
also
outlined.
Finally,
setbacks
challenges,
proposed
potential
solutions
future
directions
pointed
out.
This
review
provides
comprehensive
detailed
horizon
sonosensitizers,
will
arouse
more
attentions
SDT.
Bioactive Materials,
Год журнала:
2024,
Номер
39, С. 14 - 24
Опубликована: Май 14, 2024
Tumor-promoting
niche
after
incomplete
surgery
resection
(SR)
can
lead
to
more
aggressive
local
progression
and
distant
metastasis
with
augmented
angiogenesis-immunosuppressive
tumor
microenvironment
(TME).
Herein,
elevated
neutrophil
extracellular
traps
(NETs)
cancer-associated
neurotransmitters
(CANTs,
e.g.,
catecholamines)
are
firstly
identified
as
two
of
the
dominant
inducements.
Further,
an
injectable
fibrin-alginate
hydrogel
high
tissue
adhesion
has
been
constructed
specifically
co-deliver
NETs
inhibitor
(DNase
I)-encapsulated
PLGA
nanoparticles
unselective
β-adrenergic
receptor
blocker
(propranolol).
The
components
(i.e.,
fibrin
alginate)
respond
triggers
(thrombin
Ca2+,
respectively)
in
postoperative
bleeding
gelate,
shaping
into
interpenetrating
network
(IPN)
featuring
strength.
continuous
release
DNase
I
PR
wreck
antagonize
catecholamines
decrease
microvessel
density,
blockade
myeloid-derived
suppressor
cells,
secrete
various
proinflammatory
cytokines,
potentiate
natural
killer
cell
function
hamper
cytotoxic
T
exhaustion.
reprogrammed
TME
significantly
suppress
locally
residual
tumors,
induce
strong
immune
memory
effects
thus
inhibit
lung
metastasis.
Thus,
targetedly
degrading
blocking
CANTs
enabled
by
this
in-situ
IPN-based
drug
depot
provides
a
simple
efficient
approach
against
SR-induced
cancer
recurrence
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(13)
Опубликована: Март 3, 2024
Abstract
Curcumin,
a
natural
bioactive
polyphenol
with
diverse
molecular
targets,
is
well
known
for
its
anti‐oxidation
and
anti‐inflammatory
potential.
However,
curcumin
exhibits
low
solubility
(<1
µg
mL
−1
),
poor
tissue‐targeting
ability,
rapid
oxidative
degradation,
resulting
in
bioavailability
stability
inflammatory
therapy.
Here,
poly(diselenide‐oxalate‐curcumin)
nanoparticle
(SeOC‐NP)
dual‐reactive
oxygen
species
(ROS)
sensitive
chemical
moieties
(diselenide
peroxalate
ester
bonds)
fabricated
by
one‐step
synthetic
strategy.
The
results
confirmed
that
dual‐ROS
endowed
SeOC‐NP
the
ability
of
targeted
delivery
significantly
suppress
degradation
high‐efficiency
In
detail,
amount
SeOC
about
4‐fold
lower
than
free
an
microenvironment.
As
result,
enhanced
antioxidant
activity
efficacy
vitro
analysis
scavenging
intracellular
ROS
suppressing
secretion
nitric
oxide
pro‐inflammatory
cytokines.
mouse
colitis
models,
orally
administered
can
remarkably
alleviate
symptoms
IBD
maintain
homeostasis
gut
microbiota.
This
work
provided
simple
effective
strategy
to
fabricate
ROS‐responsive
micellar
enhance
oxidation
medicine
precise
therapeutic
inflammation.
