Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
170, С. 116074 - 116074
Опубликована: Дек. 25, 2023
Hepatocellular
carcinoma
(HCC)
remains
a
major
global
health
burden,
and
sorafenib,
multi-kinase
inhibitor,
has
shown
effectiveness
in
the
treatment
of
HCC
is
considered
as
first-line
therapy
for
advanced
HCC.
However,
response
to
sorafenib
varies
among
patients,
development
drug
resistance
poses
prevalent
obstacle.
Ferroptosis,
newly
characterized
form
cell
death
featured
by
iron-dependent
lipid
peroxidation,
emerged
critical
player
reaction
The
induction
ferroptosis
been
augment
anticancer
benefits
sorafenib.
it
also
observed
contribute
resistance.
This
review
presents
comprehensive
thorough
analysis
that
elucidates
intricate
relationship
between
over
recent
years,
aiming
formulate
effective
therapeutic
approaches
liver
cancer.
Based
on
this
exploration,
we
propose
innovative
strategies
intended
overcome
via
targeted
modulation
ferroptosis.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Март 8, 2024
Ferroptosis
is
a
non-apoptotic
form
of
regulated
cell
death
characterized
by
the
lethal
accumulation
iron-dependent
membrane-localized
lipid
peroxides.
It
acts
as
an
innate
tumor
suppressor
mechanism
and
participates
in
biological
processes
tumors.
Intriguingly,
mesenchymal
dedifferentiated
cancer
cells,
which
are
usually
resistant
to
apoptosis
traditional
therapies,
exquisitely
vulnerable
ferroptosis,
further
underscoring
its
potential
treatment
approach
for
cancers,
especially
refractory
cancers.
However,
impact
ferroptosis
on
extends
beyond
direct
cytotoxic
effect
cells.
induction
not
only
inhibits
but
also
promotes
development
due
negative
anticancer
immunity.
Thus,
comprehensive
understanding
role
crucial
successful
translation
therapy
from
laboratory
clinical
applications.
In
this
review,
we
provide
overview
recent
advancements
cancer,
covering
molecular
mechanisms,
functions,
regulatory
pathways,
interactions
with
microenvironment.
We
summarize
applications
immunotherapy,
radiotherapy,
systemic
therapy,
well
inhibition
various
conditions.
finally
discuss
markers,
current
challenges
future
directions
cancer.
Redox Biology,
Год журнала:
2024,
Номер
75, С. 103211 - 103211
Опубликована: Май 30, 2024
Ferroptosis
is
a
pervasive
non-apoptotic
form
of
cell
death
highly
relevant
in
various
degenerative
diseases
and
malignancies.
The
hallmark
ferroptosis
uncontrolled
overwhelming
peroxidation
polyunsaturated
fatty
acids
contained
membrane
phospholipids,
which
eventually
leads
to
rupture
the
plasma
membrane.
unique
that
it
essentially
spontaneous,
uncatalyzed
chemical
process
based
on
perturbed
iron
redox
homeostasis
contributing
process,
but
nonetheless
modulated
by
many
metabolic
nodes
impinge
cells'
susceptibility
ferroptosis.
Among
affecting
sensitivity,
several
have
emerged
as
promising
candidates
for
pharmacological
intervention,
rendering
ferroptosis-related
proteins
attractive
targets
treatment
numerous
currently
incurable
diseases.
Herein,
current
members
Germany-wide
research
consortium
focusing
research,
well
key
external
experts
who
made
seminal
contributions
this
rapidly
growing
exciting
field
gathered
provide
comprehensive,
state-of-the-art
review
Specific
topics
include:
basic
mechanisms,
vivo
relevance,
specialized
methodologies,
tools,
potential
contribution
disease
etiopathology
progression.
We
hope
article
will
not
only
established
scientists
newcomers
with
an
overview
multiple
facets
ferroptosis,
also
encourage
additional
efforts
characterize
further
molecular
pathways
modulating
ultimate
goal
develop
novel
pharmacotherapies
tackle
associated
-
or
caused
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 6, 2023
Regulation
of
cell
mortality
for
disease
treatment
has
been
the
focus
research.
Ferroptosis
is
an
iron-dependent
regulated
death
whose
mechanism
extensively
studied
since
its
discovery.
A
large
number
studies
have
shown
that
regulation
ferroptosis
brings
new
strategies
various
benign
and
malignant
diseases.
Iron
excess
lipid
peroxidation
are
primary
metabolic
features.
Therefore,
genes
involved
in
iron
metabolism
can
regulate
overload
through
direct
or
indirect
pathways,
thereby
regulating
ferroptosis.
In
addition,
glutathione
(GSH)
body’s
non-enzymatic
antioxidants
plays
a
pivotal
role
struggle
against
peroxidation.
GSH
functions
as
auxiliary
substance
peroxidase
4
(GPX4)
to
convert
toxic
peroxides
their
corresponding
alcohols.
Here,
we
reviewed
researches
on
recent
years,
comprehensively
analyzed
regulatory
process
from
metabolism,
then
described
detail
GPX4
main
antioxidant
vivo
.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1314 - 1314
Опубликована: Янв. 21, 2024
Mitochondria
are
critical
for
providing
energy
to
maintain
cell
viability.
Oxidative
phosphorylation
involves
the
transfer
of
electrons
from
substrates
oxygen
produce
adenosine
triphosphate.
also
regulate
proliferation,
metastasis,
and
deterioration.
The
flow
in
mitochondrial
respiratory
chain
generates
reactive
species
(ROS),
which
harmful
cells
at
high
levels.
stress
caused
by
ROS
accumulation
has
been
associated
with
an
increased
risk
cancer,
cardiovascular
liver
diseases.
Glutathione
(GSH)
is
abundant
cellular
antioxidant
that
primarily
synthesized
cytoplasm
delivered
mitochondria.
Mitochondrial
glutathione
(mGSH)
metabolizes
hydrogen
peroxide
within
A
long-term
imbalance
ratio
mGSH
can
cause
dysfunction,
apoptosis,
necroptosis,
ferroptosis,
may
lead
disease.
This
study
aimed
review
physiological
functions,
anabolism,
variations
organ
tissue
accumulation,
delivery
GSH
mitochondria
relationships
between
levels,
GSH/GSH
disulfide
(GSSG)
ratio,
programmed
death,
ferroptosis.
We
discuss
diseases
deficiency
related
therapeutics.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
171, С. 116115 - 116115
Опубликована: Янв. 5, 2024
Ferroptosis
and
cuproptosis,
regulated
forms
of
cell
death
resulting
from
metal
ion
accumulation,
are
closely
related
in
terms
occurrence,
metabolism,
signaling
pathways,
drug
resistance.
Notably,
it
is
now
understood
that
these
processes
play
crucial
roles
regulating
physiological
pathological
processes,
especially
tumor
development.
Consequently,
ferroptosis
cuproptosis
have
gained
increasing
significance
as
potential
targets
for
anti-cancer
This
article
systematically
outlines
the
molecular
mechanisms
cross-talk
components
both
elucidating
their
impacts
on
cancer.
Furthermore,
investigates
clinical
perspective
targeted
cancer
chemotherapy,
immunotherapy,
radiotherapy.
Our
discussion
extends
to
a
comparative
analysis
nanoparticles
developed
based
cancer,
contrasting
them
with
current
conventional
therapies.
Opportunities
challenges
treatment
explored,
emphasizing
therapeutic
direction
co-targeting
cuproptosis.
The
also
attempts
analyze
applications
this
approach
while
summarizing
existing
barriers
require
overcoming.
Journal of Hematology & Oncology,
Год журнала:
2024,
Номер
17(1)
Опубликована: Июнь 6, 2024
Abstract
Ferroptosis,
an
iron-dependent
form
of
cell
death
characterized
by
uncontrolled
lipid
peroxidation,
is
governed
molecular
networks
involving
diverse
molecules
and
organelles.
Since
its
recognition
as
a
non-apoptotic
pathway
in
2012,
ferroptosis
has
emerged
crucial
mechanism
numerous
physiological
pathological
contexts,
leading
to
significant
therapeutic
advancements
across
wide
range
diseases.
This
review
summarizes
the
fundamental
mechanisms
regulatory
pathways
underlying
ferroptosis,
including
both
GPX4-dependent
-independent
antioxidant
mechanisms.
Additionally,
we
examine
involvement
various
conditions,
cancer,
neurodegenerative
diseases,
sepsis,
ischemia–reperfusion
injury,
autoimmune
disorders,
metabolic
disorders.
Specifically,
explore
role
response
chemotherapy,
radiotherapy,
immunotherapy,
nanotherapy,
targeted
therapy.
Furthermore,
discuss
pharmacological
strategies
for
modulating
potential
biomarkers
monitoring
this
process.
Lastly,
elucidate
interplay
between
other
forms
regulated
death.
Such
insights
hold
promise
advancing
our
understanding
context
human
health
disease.
