Journal of Neural Transmission,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 4, 2025
Abstract
Aneurysmal
subarachnoid
hemorrhage
(aSAH)
is
a
debilitating
condition
with
significant
morbidity
and
mortality
rates.
Despite
advancements
in
treatment,
understanding
the
underlying
pathophysiology,
particularly
inflammatory
response,
remains
crucial
for
improving
patient
outcomes.
In
this
study,
we
investigated
presence
of
transmembrane
protein
119
(TMEM119)
microglial
cells
cerebrospinal
fluid
(CSF)
as
potential
marker
neuroinflammation
following
aSAH.
CSF
samples
were
collected
from
aSAH
patients,
pathological
healthy
controls,
processed,
analyzed
using
immunocytochemistry.
TMEM119-positive
consistently
identified
exhibiting
amoeboid
morphology
intense
staining.
Importantly,
detected
early
first
day
post-bleeding,
persisting
throughout
acute
phase
some
cases.
Analysis
consecutive
revealed
varying
trends
cell
numbers,
peak
during
initial
followed
by
gradual
decline.
Our
findings
suggest
that
microglia
may
migrate
into
aSAH,
potentially
serving
an
predictor
inflammatory-related
CNS
damage.
This
study
underscores
importance
neuroinflammatory
processes
opens
avenues
further
research
on
role
disorders
liquid
biopsy.
Science,
Год журнала:
2024,
Номер
385(6704), С. 80 - 86
Опубликована: Июль 4, 2024
Classical
migraine
patients
experience
aura,
which
is
transient
neurological
deficits
associated
with
cortical
spreading
depression
(CSD),
preceding
headache
attacks.
It
not
currently
understood
how
a
pathological
event
in
cortex
can
affect
peripheral
sensory
neurons.
In
this
study,
we
show
that
cerebrospinal
fluid
(CSF)
flows
into
the
trigeminal
ganglion,
establishing
nonsynaptic
signaling
between
brain
and
cells.
After
CSD,
~11%
of
CSF
proteome
altered,
up-regulation
proteins
directly
activate
receptors
ganglion.
collected
from
animals
exposed
to
CSD
activates
neurons
naïve
mice
part
by
CSF-borne
calcitonin
gene-related
peptide
(CGRP).
We
identify
communication
pathway
central
nervous
system
might
explain
relationship
migrainous
aura
headache.
Science Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Our
understanding
of
the
meningeal
immune
system
has
recently
burgeoned,
particularly
regarding
how
innate
and
adaptive
effector
cells
are
mobilized
to
meet
brain
challenges.
However,
information
on
immunocytes
guard
homeostasis
in
healthy
individuals
remains
limited.
This
study
highlights
heterogeneous,
polyfunctional
regulatory
T
cell
(T
reg
)
compartment
meninges.
A
subtype
specialized
controlling
interferon-gamma
(IFN-γ)
responses
another
dedicated
regulating
follicular
B
were
substantial
components
this
compartment.
Accordingly,
punctual
ablation
rapidly
unleashed
IFN-γ
production
by
lymphocytes,
unlocked
access
parenchyma,
altered
profiles.
Distally,
hippocampus
assumed
a
reactive
state,
with
morphological
transcriptional
changes
multiple
glial
types.
Within
dentate
gyrus,
neural
stem
underwent
more
death
blocked
from
further
differentiation,
which
coincided
impairments
short-term
spatial-reference
memory.
Thus,
regs
multifaceted
safeguard
at
steady
state.
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(42)
Опубликована: Окт. 7, 2024
The
glymphatic
pathway
was
defined
in
rodents
as
a
network
of
perivascular
spaces
(PVSs)
that
facilitates
organized
distribution
cerebrospinal
fluid
(CSF)
into
the
brain
parenchyma.
To
date,
CSF
and
cerebral
interstitial
exchange
has
not
been
shown
humans.
Using
intrathecal
gadolinium
contrast-enhanced
MRI,
we
show
moves
through
PVS
parenchyma,
supporting
existence
Nature Medicine,
Год журнала:
2024,
Номер
30(10), С. 2947 - 2956
Опубликована: Июль 31, 2024
The
ecosystem
of
brain
tumors
is
considered
immunosuppressed,
but
our
current
knowledge
may
be
incomplete.
Here
we
analyzed
clinical
cell
and
tissue
specimens
derived
from
patients
presenting
with
glioblastoma
or
nonmalignant
intracranial
disease
to
report
that
the
cranial
bone
(CB)
marrow,
in
juxtaposition
treatment-naive
tumors,
harbors
active
lymphoid
populations
at
time
initial
diagnosis.
Clinical
anatomical
imaging,
single-cell
molecular
immune
profiling
quantification
tumor
reactivity
identified
CD8
Science Translational Medicine,
Год журнала:
2024,
Номер
16(766)
Опубликована: Сен. 25, 2024
Neuroimmune
interactions
are
essential
for
the
development
of
neuropathic
pain,
yet
contributions
distinct
immune
cell
populations
have
not
been
fully
unraveled.
Here,
we
demonstrate
critical
role
B
cells
in
promoting
mechanical
hypersensitivity
(allodynia)
after
peripheral
nerve
injury
male
and
female
mice.
Depletion
with
a
single
injection
anti-CD20
monoclonal
antibody
at
time
prevented
allodynia.
cell–deficient
(muMT)
mice
were
similarly
spared
from
Nerve
was
associated
increased
immunoglobulin
G
(IgG)
accumulation
ipsilateral
lumbar
dorsal
root
ganglia
(DRGs)
spinal
cords.
IgG
colocalized
sensory
neurons
macrophages
DRGs
microglia
also
accumulated
DRG
samples
human
donors
chronic
colocalizing
marker
satellite
glia.
RNA
sequencing
revealed
population
naive
mouse
DRGs.
A
transcriptional
signature
enriched
pain.
Passive
transfer
injured
induced
allodynia
muMT
recipient
The
pronociceptive
effects
likely
mediated
through
complexes
interacting
Fc
gamma
receptors
(FcγRs)
expressed
by
neurons,
microglia,
macrophages,
given
that
both
hyperexcitability
dissociated
abolished
nerve-injured
FcγR-deficient
Consistently,
passive
lost
These
data
reveal
cell–IgG–FcγR
axis
is
required
pain
