Health outcomes one year after Omicron infection among 12,789 adults: a community-based cross-sectional study

The Lancet Regional Health - Western Pacific, Год журнала: 2025, Номер unknown, С. 101507 - 101507

Опубликована: Март 1, 2025

Characterizing the paradigm and impact of long COVID is crucial for addressing this worldwide health challenge. This study aimed to investigate prevalence one year after primary Omicron infection characterize differences in long-term consequence between participants with persistent those who fully recovered. a community-based cross-sectional conducted from December 2023 March 2024 at China-Japan Friendship Hospital 16 administrative districts Beijing. 12,789 infected 2022 January were recruited through stratified multistage random sampling included final analysis. Of them, 376 229 without matched further physical examinations. The outcome was infection. Secondary outcomes muscle strength, exercise capacity, health-related quality life (HRQoL), mental health, work status, laboratory tests, Among (media [IQR] age, 48.4 [37.3 61.4] years; 7817 females [61.1%]), 995 them (7.8%) experienced within year, 651 (5.1%) having symptoms. Fatigue (598/995 [60.1%]) post-exertional malaise (367/995 [36.9%]) most common Brain fog had lowest resolution proportion as 4.2% year. odds increased reinfections (odds ratios reinfection 2.592 [95% CI: 2.188 3.061]; two or more: 6.171 [3.227 11.557]; all p < 0.001). Participants markedly lower strength (upper-limb: 26.9 ± 12.4 vs. 29.1 14.5 Kg; lower-limb: 40.0 [27.0 62.0] 43.0 [28.0 59.0] s), worse capacity poorer HRQoL, meaningful difference tests results compared COVID. They also exhibited significantly higher proportions abnormal lung function (FEV1 %pred<80%: 13.0% 2.0%; DLco 32.7% 19.9%) imaging abnormalities (23.5% 13.6%). considerable burden progression neurological symptoms following warrant close monitoring. Utilizing professional questionnaires developing reliable diagnostic tools are necessary improving diagnosis treatment supported by Beijing Research Center Respiratory Infectious Diseases (BJRID2024-012), Chinese Academy Medical Sciences Innovation Fund (2022-I2M-CoV19-005/CIFMS 2021-I2M-1-048), National Natural Science Foundation China (82241056/82200114/82200009), New Cornerstone Foundation.

Язык: Английский

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Impact of SARS-CoV-2 Variants and Vaccination on Pediatric Febrile Seizures: A Retrospective Cohort Study

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Objective This study aimed to investigate the associations between SARS-CoV-2 variants, neuroinflammatory markers, vaccination history, and demographic characteristics in relation occurrence of febrile seizures (FS) pediatric patients at a single tertiary medical center. Methods Retrospective cohort data were collected from care institution April 2020 January 2023, encompassing 339 with PCR-confirmed infections. The was separated into FS (n=102) control (n=237) groups. A multivariable logistic regression analysis employed evaluate impact viral variants (Delta Omicron sublineages), inflammatory markers (IL-6, D-dimer, CRP), status (unvaccinated, partially vaccinated, fully vaccinated), variables, while controlling for potential confounders. Results incidence among infants under one year age found be 41.2%, contrast 17.7% older children (OR=3.2, 95% CI: 1.8–5.7; P<0.001). Elevated levels IL-6 exceeding 10 pg/mL D-dimer surpassing 0.5 mg/L independently associated increased severity (adjusted OR [aOR]=2.8 2.1, respectively), as well 3.1-fold increase risk recurrence. Full linked 68% reduction (aOR=0.32, 0.18–0.55), particularly benefiting infants. Additionally, male exhibited 1.8-fold vulnerability (P=0.016). sublineages (BA.5/XBB), which accounted 78.4% cases, correlated heightened biomarker levels. Conclusion findings suggest that serve valuable indicators assessing infected SARS-CoV-2. protective effect on neural tissues, addition its role reducing transmission, is evident, highlighting susceptibility

Язык: Английский

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Spike Protein–Fibrinogen Interaction: A Novel Immune Evasion Strategy of SARS-CoV-2?

ACS Pharmacology & Translational Science, Год журнала: 2025, Номер 8(4), С. 1182 - 1184

Опубликована: Март 19, 2025

The host protein fibrinogen has been found to interact with the N-terminal domain (NTD) of spike in SARS-CoV-2. However, evolutionary benefit this binding virus still remains unclear. Herein, we put forward rationale and supporting evidence that its more conserved NTD is an immune evasion strategy adopted by outsmart targeted neutralizing antibodies.

Язык: Английский

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The impact and projection of the COVID-19 pandemic on the burden of stroke at global, regional, and national levels: a comprehensive analysis for the Global Burden of Disease Study 2021

Journal of Stroke and Cerebrovascular Diseases, Год журнала: 2025, Номер unknown, С. 108320 - 108320

Опубликована: Апрель 1, 2025

We aim to estimate impact and projection of the COVID-19 pandemic on burden stroke at global, regional, national levels METHODS: Utilizing standardized GBD methodologies, we conducted a comprehensive analysis prevalence, incidence, mortality, disability-adjusted life years (DALYs) associated with across 204 countries regions spanning periods from 1990 2019, 2019 2021, 2021. Our study provides detailed estimates accompanied by corresponding 95% uncertainty intervals (UIs), stratified age sex. To elucidate temporal trends in burden, calculated Estimated Annual Percentage Change (EAPC). Additionally, explored relationship between sociodemographic index (SDI) levels. The DALYs attributable various risk factors for were also analyzed. next 20 was predicted. From age-standardized prevalence rates (ASPR), incidence (ASIR), mortality (ASMR), remained stable, diverging declining observed 2021 levels, as indicated both percent change EAPC analysis. This pattern similarly reflected global intracerebral hemorrhage (ICH), subarachnoid (SAH), ischemic (IS). changes stroke, ICH, IS consistent males females. Importantly, remains substantial, irrespective variations SDI. increased years, more attention should be paid young people. Throughout pandemic, exhibited stable trajectory, contrast trend people years. These observations highlight disparities that exist different socioeconomic development. longitudinal epidemiological data presented this provide valuable insights into significant shifts brought about offering crucial information researchers, policymakers, healthcare professionals, other stakeholders.

Язык: Английский

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Pioneering discovery and therapeutics at the brain-vascular-immune interface

Cell, Год журнала: 2024, Номер 187(21), С. 5871 - 5876

Опубликована: Окт. 1, 2024

Язык: Английский

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Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models

Cell Reports, Год журнала: 2024, Номер 43(11), С. 114870 - 114870

Опубликована: Окт. 19, 2024

Язык: Английский

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Detrimental Effects of Anti-Nucleocapsid Antibodies in SARS-CoV-2 Infection, Reinfection, and the Post-Acute Sequelae of COVID-19

Pathogens, Год журнала: 2024, Номер 13(12), С. 1109 - 1109

Опубликована: Дек. 15, 2024

Antibody-dependent enhancement (ADE) is a phenomenon in which antibodies enhance subsequent viral infections rather than preventing them. Sub-optimal levels of neutralizing individuals infected with dengue virus are known to be associated severe disease upon reinfection different serotype. For Severe Acute Respiratory Syndrome Coronavirus type-2 infection, three types ADE have been proposed: (1) Fc receptor-dependent infection cells expressing receptors, such as macrophages by anti-spike antibodies, (2) receptor-independent epithelial and (3) cytokine production anti-nucleocapsid antibodies. This review focuses on the induced examining its potential role COVID-19 during contribution post-acute sequelae COVID-19, i.e., prolonged symptoms lasting at least months after acute phase disease. We also discuss protective effects recently identified that neutralize Omicron variants.

Язык: Английский

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Fibrinaloid microclots in Long COVID: assessing the actual evidence properly

Research and Practice in Thrombosis and Haemostasis, Год журнала: 2024, Номер 8(7), С. 102566 - 102566

Опубликована: Сен. 10, 2024

Язык: Английский

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COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle

Trends in Immunology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Low-Grade Inflammation in Long COVID Syndrome Sustains a Persistent Platelet Activation Associated With Lung Impairment

JACC Basic to Translational Science, Год журнала: 2024, Номер 10(1), С. 20 - 39

Опубликована: Ноя. 27, 2024

In the present study, we provide evidence on potential mechanisms involved in residual pulmonary impairment described long COVID syndrome. Data highlight that lung damage is significantly associated with a proinflammatory platelet phenotype, characterized mainly by formation of platelet-leukocyte aggregates. ex vivo experiments, plasma reproduces activation observed and highlights low-grade inflammation as underpinning mechanism, exploiting synergistic activity between C-reactive protein subthreshold concentrations interleukin-6. The platelet-activated phenotype blunted anti-inflammatory antiplatelet drugs, suggesting therapeutic option this clinical setting.

Язык: Английский

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