Biology,
Год журнала:
2023,
Номер
12(2), С. 256 - 256
Опубликована: Фев. 6, 2023
Each
cell
in
a
multicellular
organism
has
its
own
phenotype
despite
sharing
the
same
genome.
Epigenetics
is
somatic,
heritable
pattern
of
gene
expression
or
cellular
mediated
by
structural
changes
chromatin
that
occur
without
altering
DNA
sequence.
Epigenetic
modification
an
important
factor
determining
level
and
timing
response
to
endogenous
exogenous
stimuli.
There
also
growing
evidence
concerning
interaction
between
epigenetics
metabolism.
Accordingly,
several
enzymes
consume
vital
metabolites
as
substrates
cofactors
are
used
during
catalysis
epigenetic
modification.
Therefore,
altered
metabolism
might
lead
diseases
pathogenesis,
including
endocrine
disorders
cancer.
In
addition,
it
been
demonstrated
influences
system
immune
response-related
pathways.
this
regard,
may
impact
levels
hormones
regulating
growth,
development,
reproduction,
energy
balance,
Altering
function
negative
health
consequences.
Furthermore,
disruptors
(EDC)
have
significant
on
system,
causing
abnormal
functioning
their
receptors,
resulting
various
disorders.
Overall,
review
focuses
with
Abstract
Epigenome
reprogramming
after
fertilization
enables
transcriptionally
quiescent
maternal
and
paternal
chromatin
to
acquire
a
permissive
state
for
subsequent
zygotic
genome
activation
(ZGA).
H3K27
acetylation
(H3K27ac)
is
well‐established
marker
of
active
enhancers
promoters.
However,
dynamics
H3K27ac
during
maternal‐to‐zygotic
transition
(MZT)
in
mammalian
embryos
are
not
well‐studied.
By
profiling
the
allelic
landscape
mouse
MZT,
we
show
that
undergoes
three
waves
rapid
global
transitions
between
oocyte
stage
2‐cell
stage.
Notably,
germinal
vesicle
zygote
globally
hyperacetylated,
with
noncanonical,
broad
domains
correlate
H3K4
trimethylation
(H3K4me3)
open
chromatin.
marks
genomic
regions
primed
including
ZGA
genes,
retrotransposons,
alleles
imprinted
genes.
We
CBP/p300
HDAC
activities
play
important
roles
regulating
essential
preimplantation
development.
Specifically,
acetyltransferase
broadly
deposits
zygotes
induce
opening
condensed
at
putative
ensure
proper
ZGA.
On
contrary,
HDACs
revert
canonical
safeguard
by
preventing
premature
expression
developmental
In
conclusion,
coordinated
MZT
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Апрель 14, 2023
Abstract
Although
more
studies
are
demonstrating
that
a
father’s
environment
can
influence
child
health
and
disease,
the
molecular
mechanisms
underlying
non-genetic
inheritance
remain
unclear.
It
was
previously
thought
sperm
exclusively
contributed
its
genome
to
egg.
More
recently,
association
have
shown
various
environmental
exposures
including
poor
diet,
toxicants,
stress,
perturbed
epigenetic
marks
in
at
important
reproductive
developmental
loci
were
associated
with
offspring
phenotypes.
The
cellular
routes
underlie
how
transmitted
fertilization,
resist
reprogramming
embryo,
drive
phenotypic
changes
only
now
beginning
be
unraveled.
Here,
we
provide
an
overview
of
state
field
intergenerational
paternal
mammals
present
new
insights
into
relationship
between
embryo
development
three
pillars
inheritance:
chromatin,
DNA
methylation,
non-coding
RNAs.
We
evaluate
compelling
evidence
sperm-mediated
transmission
retention
embryo.
Using
landmark
examples,
discuss
sperm-inherited
regions
may
escape
impact
via
implicate
transcription
factors,
chromatin
organization,
transposable
elements.
Finally,
link
paternally
functional
pre-
post-implantation
Understanding
factors
will
permit
greater
understanding
related
origins
disease.
Cold Spring Harbor Perspectives in Biology,
Год журнала:
2021,
Номер
14(6), С. a039677 - a039677
Опубликована: Авг. 16, 2021
Dramatic
nuclear
reorganization
occurs
during
early
development
to
convert
terminally
differentiated
gametes
a
totipotent
zygote,
which
then
gives
rise
an
embryo.
Aberrant
epigenome
resetting
severely
impairs
embryo
and
even
leads
lethality.
How
the
epigenomes
are
inherited,
reprogrammed,
reestablished
in
this
critical
developmental
period
has
gradually
been
unveiled
through
rapid
of
technologies
including
ultrasensitive
chromatin
analysis
methods.
In
review,
we
summarize
latest
findings
on
epigenetic
reprogramming
gametogenesis
embryogenesis,
how
it
contributes
gamete
maturation
parental-to-zygotic
transition.
Finally,
highlight
key
questions
that
remain
be
answered
fully
understand
regulation
development.
