Genome biology,
Journal Year:
2023,
Volume and Issue:
24(1)
Published: March 14, 2023
Abstract
Background
Genomic
imprinting
affects
gene
expression
in
a
parent-of-origin
manner
and
has
profound
impact
on
complex
traits
including
growth
behavior.
While
the
rat
is
widely
used
to
model
human
pathophysiology,
few
imprinted
genes
have
been
identified
this
murid.
To
systematically
identify
genomic
imprints
rat,
we
use
low
input
methods
for
genome-wide
analyses
of
DNA
methylation
profile
embryonic
extraembryonic
tissues
at
allele-specific
resolution.
Results
We
14
26
these
tissues,
respectively,
with
10
both
tissues.
Comparative
mouse
reveal
that
orthologous
associated
canonical
are
conserved
embryo
proper
Muridae
family.
However,
only
3
paternally
expressed
tissue
murids,
all
which
non-canonical
H3K27me3
imprints.
The
discovery
8
novel
unique
consistent
more
rapid
evolution
imprinting.
Meta-analysis
reveals
multiple
mechanisms
by
species-specific
may
be
established,
deposition
oocyte,
appearance
ZFP57
binding
motifs,
insertion
endogenous
retroviral
promoters.
Conclusions
In
summary,
provide
an
expanded
list
loci
extent
conservation
expression,
potential
responsible
The EMBO Journal,
Journal Year:
2022,
Volume and Issue:
41(22)
Published: Oct. 10, 2022
Abstract
Epigenome
reprogramming
after
fertilization
enables
transcriptionally
quiescent
maternal
and
paternal
chromatin
to
acquire
a
permissive
state
for
subsequent
zygotic
genome
activation
(ZGA).
H3K27
acetylation
(H3K27ac)
is
well‐established
marker
of
active
enhancers
promoters.
However,
dynamics
H3K27ac
during
maternal‐to‐zygotic
transition
(MZT)
in
mammalian
embryos
are
not
well‐studied.
By
profiling
the
allelic
landscape
mouse
MZT,
we
show
that
undergoes
three
waves
rapid
global
transitions
between
oocyte
stage
2‐cell
stage.
Notably,
germinal
vesicle
zygote
globally
hyperacetylated,
with
noncanonical,
broad
domains
correlate
H3K4
trimethylation
(H3K4me3)
open
chromatin.
marks
genomic
regions
primed
including
ZGA
genes,
retrotransposons,
alleles
imprinted
genes.
We
CBP/p300
HDAC
activities
play
important
roles
regulating
essential
preimplantation
development.
Specifically,
acetyltransferase
broadly
deposits
zygotes
induce
opening
condensed
at
putative
ensure
proper
ZGA.
On
contrary,
HDACs
revert
canonical
safeguard
by
preventing
premature
expression
developmental
In
conclusion,
coordinated
MZT
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: April 14, 2023
Abstract
Although
more
studies
are
demonstrating
that
a
father’s
environment
can
influence
child
health
and
disease,
the
molecular
mechanisms
underlying
non-genetic
inheritance
remain
unclear.
It
was
previously
thought
sperm
exclusively
contributed
its
genome
to
egg.
More
recently,
association
have
shown
various
environmental
exposures
including
poor
diet,
toxicants,
stress,
perturbed
epigenetic
marks
in
at
important
reproductive
developmental
loci
were
associated
with
offspring
phenotypes.
The
cellular
routes
underlie
how
transmitted
fertilization,
resist
reprogramming
embryo,
drive
phenotypic
changes
only
now
beginning
be
unraveled.
Here,
we
provide
an
overview
of
state
field
intergenerational
paternal
mammals
present
new
insights
into
relationship
between
embryo
development
three
pillars
inheritance:
chromatin,
DNA
methylation,
non-coding
RNAs.
We
evaluate
compelling
evidence
sperm-mediated
transmission
retention
embryo.
Using
landmark
examples,
discuss
sperm-inherited
regions
may
escape
impact
via
implicate
transcription
factors,
chromatin
organization,
transposable
elements.
Finally,
link
paternally
functional
pre-
post-implantation
Understanding
factors
will
permit
greater
understanding
related
origins
disease.
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2021,
Volume and Issue:
14(6), P. a039677 - a039677
Published: Aug. 16, 2021
Dramatic
nuclear
reorganization
occurs
during
early
development
to
convert
terminally
differentiated
gametes
a
totipotent
zygote,
which
then
gives
rise
an
embryo.
Aberrant
epigenome
resetting
severely
impairs
embryo
and
even
leads
lethality.
How
the
epigenomes
are
inherited,
reprogrammed,
reestablished
in
this
critical
developmental
period
has
gradually
been
unveiled
through
rapid
of
technologies
including
ultrasensitive
chromatin
analysis
methods.
In
review,
we
summarize
latest
findings
on
epigenetic
reprogramming
gametogenesis
embryogenesis,
how
it
contributes
gamete
maturation
parental-to-zygotic
transition.
Finally,
highlight
key
questions
that
remain
be
answered
fully
understand
regulation
development.
