Cancer metabolism: looking forward

Nature reviews. Cancer, Год журнала: 2021, Номер 21(10), С. 669 - 680

Опубликована: Июль 16, 2021

Язык: Английский

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The role of ROS in tumour development and progression

Nature reviews. Cancer, Год журнала: 2022, Номер 22(5), С. 280 - 297

Опубликована: Янв. 31, 2022

Язык: Английский

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Cell-programmed nutrient partitioning in the tumour microenvironment

Nature, Год журнала: 2021, Номер 593(7858), С. 282 - 288

Опубликована: Апрель 7, 2021

Язык: Английский

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Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways

Nature Reviews Clinical Oncology, Год журнала: 2021, Номер 19(1), С. 37 - 50

Опубликована: Сен. 27, 2021

Язык: Английский

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Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Signal Transduction and Targeted Therapy, Год журнала: 2023, Номер 8(1)

Опубликована: Фев. 17, 2023

Abstract Having a hypoxic microenvironment is common and salient feature of most solid tumors. Hypoxia has profound effect on the biological behavior malignant phenotype cancer cells, mediates effects chemotherapy, radiotherapy, immunotherapy through complex mechanisms, closely associated with poor prognosis in various patients. Accumulating studies have demonstrated that normalization tumor vasculature, nanoparticle carriers biocarriers can effectively increase oxygen concentration microenvironment, improve drug delivery efficacy radiotherapy. They also infiltration innate adaptive anti-tumor immune cells to enhance immunotherapy. Furthermore, drugs targeting key genes hypoxia, including hypoxia tracers, hypoxia-activated prodrugs, hypoxia-inducible factors downstream targets, be used for visualization quantitative analysis antitumor activity. However, relationship between an area research requires further exploration. Here, we investigated potential development cancer, changes signaling pathways occur adapt environments, mechanisms hypoxia-induced tolerance, chemotherapeutic enhanced radiation as well insights applications therapy.

Язык: Английский

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Clinical implications of T cell exhaustion for cancer immunotherapy

Nature Reviews Clinical Oncology, Год журнала: 2022, Номер 19(12), С. 775 - 790

Опубликована: Окт. 10, 2022

Язык: Английский

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The role of m6A RNA methylation in cancer metabolism

Molecular Cancer, Год журнала: 2022, Номер 21(1)

Опубликована: Янв. 12, 2022

Abstract Metabolic reprogramming is one of the main characteristics malignant tumors, which due to flexible changes cell metabolism that can meet needs growth and maintain homeostasis tissue environments. Cancer cells obtain metabolic adaptation through a variety endogenous exogenous signaling pathways, not only promote cancer cells, but also start transformation process adapt tumor microenvironment. Studies show m6A RNA methylation widely involved in recombination cells. In eukaryotes, most abundant modification mRNA, almost all cycle stages, including regulation transcription, maturation, translation, degradation stability mRNA. M6A be physiological pathological processes, cancer. this review, we discuss role plays metabolism-related molecules aiming importance targeting regulating metabolism.

Язык: Английский

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Ferroptosis in cancer and cancer immunotherapy

Cancer Communications, Год журнала: 2022, Номер 42(2), С. 88 - 116

Опубликована: Фев. 1, 2022

Abstract The hallmark of tumorigenesis is the successful circumvention cell death regulation for achieving unlimited replication and immortality. Ferroptosis a newly identified type dependent on lipid peroxidation which differs from classical programmed in terms morphology, physiology biochemistry. broad spectrum injury tumor tolerance are main reasons radiotherapy chemotherapy failure. effective rate immunotherapy as new treatment method less than 30%. can be seen radiotherapy, chemotherapy, immunotherapy; therefore, ferroptosis activation may potential strategy to overcome drug resistance mechanism traditional cancer treatments. In this review, characteristics causes by briefly described. addition, three metabolic regulations its crosstalk with signaling pathways summarized. Collectively, these findings suggest vital role based interaction immunotherapy, thus, indicating remarkable treatment.

Язык: Английский

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Hallmarks of T cell aging

Nature Immunology, Год журнала: 2021, Номер 22(6), С. 687 - 698

Опубликована: Май 13, 2021

Язык: Английский

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CD8+ T cell metabolism in infection and cancer

Nature reviews. Immunology, Год журнала: 2021, Номер 21(11), С. 718 - 738

Опубликована: Май 12, 2021

Язык: Английский

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