Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 29, 2023
At
the
turn
of
century,
researchers
discovered
a
unique
subtype
T
helper
cells
that
secretes
IL-17
and
defined
it
as
Th17.
The
latest
study
found
Th17
play
both
positive
negative
definitive
roles
in
regulation
antitumor
immune
responses.
Although
function
tumor
microenvironment
remains
poorly
understood,
more
studies
have
shown
this
paradoxical
dual
role
is
closely
related
to
plasticity
recent
decades.
Further
understanding
characteristics
could
yield
novel
useful
therapeutic
approaches
treat
cancer.
In
review,
we
further
present
high
Th17-producing
immunity.
European Journal of Immunology,
Год журнала:
2021,
Номер
51(12), С. 2708 - 3145
Опубликована: Дек. 1, 2021
Abstract
The
third
edition
of
Flow
Cytometry
Guidelines
provides
the
key
aspects
to
consider
when
performing
flow
cytometry
experiments
and
includes
comprehensive
sections
describing
phenotypes
functional
assays
all
major
human
murine
immune
cell
subsets.
Notably,
contain
helpful
tables
highlighting
differences
between
cells.
Another
useful
feature
this
is
analysis
clinical
samples
with
examples
applications
in
context
autoimmune
diseases,
cancers
as
well
acute
chronic
infectious
diseases.
Furthermore,
there
are
detailing
tips,
tricks
pitfalls
avoid.
All
written
peer‐reviewed
by
leading
experts
immunologists,
making
an
essential
state‐of‐the‐art
handbook
for
basic
researchers.
Immunity,
Год журнала:
2022,
Номер
55(1), С. 14 - 30
Опубликована: Янв. 1, 2022
Adaptive
immune
responses
mediated
by
T
cells
and
B
are
crucial
for
protective
immunity
against
pathogens
tumors.
Differentiation
function
of
require
dynamic
reprogramming
cellular
metabolism.
Metabolic
inputs,
pathways,
enzymes
display
remarkable
flexibility
heterogeneity,
especially
in
vivo.
How
metabolic
plasticity
adaptation
dictate
functional
specialization
is
fundamental
to
our
understanding
therapeutic
modulation
the
system.
Extensive
progress
has
been
made
characterizing
effects
networks
on
cell
fate
discrete
microenvironments
or
immunological
contexts.
In
this
review,
we
summarize
how
rewiring
metabolism
determines
outcome
adaptive
vivo,
with
a
focus
metabolites,
nutrients,
driver
genes
immunometabolism
instruct
programming
during
infection,
inflammation,
cancer
mice
humans.
Understanding
context-dependent
remodeling
will
manifest
legitimate
opportunities
intervention
human
disease.
Journal of Hematology & Oncology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Ноя. 1, 2022
Colorectal
cancer
(CRC)
is
the
third
most
common
and
second
leading
cause
of
cancer-related
death
worldwide.
Countless
CRC
patients
undergo
disease
progression.
As
a
hallmark
cancer,
Warburg
effect
promotes
metastasis
remodels
tumor
microenvironment,
including
promoting
angiogenesis,
immune
suppression,
cancer-associated
fibroblasts
formation
drug
resistance.
Targeting
metabolism
would
be
promising
method
for
treatment
CRC.
In
this
review,
we
summarize
information
about
roles
in
microenvironment
to
elucidate
mechanisms
governing
identify
novel
targets
therapy.
ACS Nano,
Год журнала:
2022,
Номер
16(9), С. 15471 - 15483
Опубликована: Авг. 18, 2022
Both
T-cell
deprivation
and
insufficient
tumor
immunogenicity
seriously
hinder
the
efficacy
of
immune-mediated
destruction
in
melanoma.
In
this
work,
an
amphiphilic
polyethylene
glycol-poly(2-hexoxy-2-oxo-1,3,2-dioxaphospholane)
copolymer
with
a
thermally
sensitive
flowable
core
(mPEG-b-PHEP)
was
chosen
to
incorporate
IR780
dye
manganese
zinc
sulfide
nanoparticles
(ZMS)
form
polymer
micelles
(denoted
PPIR780-ZMS),
which
precisely
controlled
release
ZMS
after
being
triggered
by
near-infrared
light
(NIR).
Mn2+-mediated
chemodynamic
therapy
(CDT)
photothermal
trigger
boosted
generation
reactive
oxygen
species
(ROS),
making
PPIR780-ZMS
smart
bomblets
vivo.
It
demonstrated
that
could
maximize
immunogenic
cell
death
(ICD)
cancer,
is
characterized
abundant
damage-associated
molecular
pattern
(DAMP)
exposure.
As
result,
cytotoxic
T
cells
(CD8+)
helper
(CD4+)
expanded
infiltrated
neoplastic
foci,
further
reprogrammed
suppressive
microenvironment
(TME)
against
primary
pulmonary
metastases
safe
systemic
cytokine
expression.
addition,
cGAS-STING
signaling
pathway
activation
enhanced
antitumor
immunity
nanocomposite,
providing
practical
strategy
for
expanding
use
Mn-based
nanostructures.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Март 14, 2022
T
lymphocytes
(T
cells)
are
divided
into
two
functionally
different
subgroups
the
CD4+
helper
cells
(Th)
and
CD8+
cytotoxic
(CTL).
Adequate
CD4
CD8
cell
activation
to
proliferation,
clonal
expansion
effector
function
is
crucial
for
efficient
clearance
of
infection
by
pathogens.
Failure
do
so
may
lead
exhaustion.
Upon
antigen
presenting
cells,
undergo
metabolic
reprograming
that
support
functions.
In
this
review
we
will
discuss
how
dictates
functionality
during
viral
infections
using
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
human
immunodeficiency
virus
(HIV)
as
examples.
Moreover,
briefly
programs
bacterial
exemplified
Mycobacterium
tuberculosis
(MT)
infection.
Angewandte Chemie International Edition,
Год журнала:
2022,
Номер
61(43)
Опубликована: Авг. 18, 2022
Abstract
Activation
of
the
cyclic
GMP‐AMP
synthase‐stimulator
interferon
gene
(cGAS‐STING)
pathway
is
a
potent
anticancer
immunotherapeutic
strategy,
and
induction
pyroptosis
feasible
way
to
stimulate
immune
responses.
Herein,
two
Pt
II
complexes
(
Pt1
Pt2
)
were
designed
as
photoactivators
cGAS‐STING
pathway.
In
response
light
irradiation,
could
damage
mitochondrial/nuclear
DNA
nuclear
envelope
activate
pathway,
concurrently
induce
in
cancer
cells,
which
evoked
an
intense
vitro
vivo.
Overall,
we
present
first
photoactivator
may
provide
innovative
design
strategy
for
immunotherapy.
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Янв. 27, 2023
Cyclooxygenases-2
(COX-2)
and
Prostaglandin
E2
(PGE2),
which
are
important
in
chronic
inflammatory
diseases,
can
increase
tumor
incidence
promote
growth
metastasis.
PGE2
binds
to
various
prostaglandin
E
receptors
activate
specific
downstream
signaling
pathways
such
as
PKA
pathway,
β-catenin
NF-κB
pathway
PI3K/AKT
all
of
play
roles
biological
pathological
behavior.
Nonsteroidal
anti-inflammatory
drugs
(NSAIDs),
COX-2
inhibitors,
EP
antagonists
anti-tumor
immune
evasion.
The
COX-2-PGE2
promotes
evasion
by
regulating
myeloid-derived
suppressor
cells,
lymphocytes
(CD8+
T
CD4+
cells
natural
killer
cells),
antigen
presenting
(macrophages
dendritic
cells).
Based
on
conventional
treatment,
the
addition
inhibitors
or
may
enhance
immunotherapy
response
escape.
However,
there
still
a
lot
challenges
cancer
immunotherapy.
In
this
review,
we
focus
how
affects
tumor-associated
cells.
