Nutrients,
Год журнала:
2023,
Номер
15(8), С. 1853 - 1853
Опубликована: Апрель 12, 2023
Declines
in
physical
performance
and
cognition
are
commonly
observed
older
adults.
The
geroscience
paradigm
posits
that
a
set
of
processes
pathways
shared
among
age-associated
conditions
may
also
serve
as
molecular
explanation
for
the
complex
pathophysiology
frailty,
sarcopenia,
cognitive
decline.
Mitochondrial
dysfunction,
inflammation,
metabolic
alterations,
declines
cellular
stemness,
altered
intracellular
signaling
have
been
muscle
aging.
Neurological
factors
included
determinants
sarcopenia.
Neuromuscular
junctions
(NMJs)
synapses
bridging
nervous
skeletal
systems
with
relevant
role
age-related
musculoskeletal
derangement.
Patterns
circulating
neurotrophic
associated
frailty
These
mostly
related
to
disarrangements
protein-to-energy
conversion
well
reduced
calorie
protein
intake
sustain
mass.
A
link
between
sarcopenia
decline
adults
has
described
possible
muscle-derived
mediators
(i.e.,
myokines)
mediating
muscle–brain
crosstalk.
Herein,
we
discuss
main
mechanisms
involved
axis
their
implication
An
overview
current
behavioral
strategies
allegedly
act
on
is
provided.
Genes,
Год журнала:
2019,
Номер
10(9), С. 720 - 720
Опубликована: Сен. 17, 2019
Physical
activity
(PA)
has
been
central
in
the
life
of
our
species
for
most
its
history,
and
thus
shaped
physiology
during
evolution.
However,
only
recently
health
consequences
a
sedentary
lifestyle,
highly
energetic
diets,
are
becoming
clear.
It
also
acknowledged
that
lifestyle
diet
can
induce
epigenetic
modifications
which
modify
chromatin
structure
gene
expression,
causing
even
heritable
metabolic
outcomes.
Many
studies
have
shown
PA
reverse
at
least
some
unwanted
effects
contribute
delaying
brain
aging
degenerative
pathologies
such
as
Alzheimer’s
Disease,
diabetes,
multiple
sclerosis.
Most
importantly,
improves
cognitive
processes
memory,
analgesic
antidepressant
effects,
induces
sense
wellbeing,
giving
strength
to
ancient
principle
“mens
sana
corpore
sano”
(i.e.,
sound
mind
body).
In
this
review
we
will
discuss
potential
mechanisms
underlying
on
health,
focusing
hormones,
neurotrophins,
neurotransmitters,
release
is
modulated
by
PA,
well
intra-
extra-cellular
pathways
regulate
expression
genes
involved.
Frontiers in Aging Neuroscience,
Год журнала:
2019,
Номер
11
Опубликована: Июнь 24, 2019
Since
first
described
in
the
early
1900s,
Alzheimer's
disease
(AD)
has
risen
exponentially
prevalence
and
concern.
Research
still
drives
to
understand
etiology
pathogenesis
of
this
what
risk
factors
can
attribute
AD.
With
a
majority
AD
cases
being
sporadic
origin,
increasing
exponential
growth
an
aged
population
lack
treatment,
it
is
imperative
discover
easy
accessible
preventative
method
for
Some
increase
propensity
such
as
aging,
sex,
genetics.
Moreover,
there
are
also
modifiable
factors-in
terms
treatable
medical
conditions
lifestyle
choices-that
play
role
developing
These
have
their
own
biological
mechanisms
that
may
contribute
pathological
consequences.
In
review
article,
we
will
discuss
current
literature
how
each
these
interplay
into
development
progression
if
strategically
analyzed
treated,
could
aid
protection
against
neurodegenerative
disease.
