Translational Neurodegeneration,
Journal Year:
2023,
Volume and Issue:
12(1)
Published: Feb. 27, 2023
Abstract
Physical
exercise
is
of
great
significance
for
maintaining
human
health.
Exercise
can
provide
varying
degrees
benefits
to
cognitive
function
at
all
stages
life
cycle.
Currently,
with
the
aging
world’s
population
and
increase
expectancy,
dysfunction
has
gradually
become
a
disease
high
incidence,
which
accompanied
by
neurodegenerative
diseases
in
elderly
individuals.
Patients
often
exhibit
memory
loss,
aphasia
weakening
orientation
once
diagnosed,
are
unable
have
normal
life.
Cognitive
largely
affects
physical
mental
health,
reduces
quality
life,
causes
economic
burden
society.
At
present,
most
interventions
aimed
maintain
current
level
delay
deterioration
cognition.
In
contrast,
as
nonpharmacological
therapy
advantages
its
nontoxicity,
low
cost
universal
application.
The
molecular
mechanisms
underlying
effect
on
cognition
complex,
studies
been
extensively
centered
neural
plasticity,
direct
target
brain.
addition,
mitochondrial
stability
energy
metabolism
essential
brain
status.
Meanwhile,
organ-brain
axis
responds
induces
release
cytokines
related
this
review,
we
summarize
latest
evidence
effects
cognition,
point
out
directions
future
research.
Genes,
Journal Year:
2019,
Volume and Issue:
10(9), P. 720 - 720
Published: Sept. 17, 2019
Physical
activity
(PA)
has
been
central
in
the
life
of
our
species
for
most
its
history,
and
thus
shaped
physiology
during
evolution.
However,
only
recently
health
consequences
a
sedentary
lifestyle,
highly
energetic
diets,
are
becoming
clear.
It
also
acknowledged
that
lifestyle
diet
can
induce
epigenetic
modifications
which
modify
chromatin
structure
gene
expression,
causing
even
heritable
metabolic
outcomes.
Many
studies
have
shown
PA
reverse
at
least
some
unwanted
effects
contribute
delaying
brain
aging
degenerative
pathologies
such
as
Alzheimer’s
Disease,
diabetes,
multiple
sclerosis.
Most
importantly,
improves
cognitive
processes
memory,
analgesic
antidepressant
effects,
induces
sense
wellbeing,
giving
strength
to
ancient
principle
“mens
sana
corpore
sano”
(i.e.,
sound
mind
body).
In
this
review
we
will
discuss
potential
mechanisms
underlying
on
health,
focusing
hormones,
neurotrophins,
neurotransmitters,
release
is
modulated
by
PA,
well
intra-
extra-cellular
pathways
regulate
expression
genes
involved.
Frontiers in Aging Neuroscience,
Journal Year:
2019,
Volume and Issue:
11
Published: June 24, 2019
Since
first
described
in
the
early
1900s,
Alzheimer's
disease
(AD)
has
risen
exponentially
prevalence
and
concern.
Research
still
drives
to
understand
etiology
pathogenesis
of
this
what
risk
factors
can
attribute
AD.
With
a
majority
AD
cases
being
sporadic
origin,
increasing
exponential
growth
an
aged
population
lack
treatment,
it
is
imperative
discover
easy
accessible
preventative
method
for
Some
increase
propensity
such
as
aging,
sex,
genetics.
Moreover,
there
are
also
modifiable
factors-in
terms
treatable
medical
conditions
lifestyle
choices-that
play
role
developing
These
have
their
own
biological
mechanisms
that
may
contribute
pathological
consequences.
In
review
article,
we
will
discuss
current
literature
how
each
these
interplay
into
development
progression
if
strategically
analyzed
treated,
could
aid
protection
against
neurodegenerative
disease.
