Natural Product Reports,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Covering:
2014
to
2023
for
metabolomics,
2002
information
visualizationLC-MS/MS-based
untargeted
metabolomics
is
a
rapidly
developing
research
field
spawning
increasing
numbers
of
computational
tools
assisting
researchers
with
their
complex
data
processing,
analysis,
and
interpretation
tasks.
In
this
article,
we
review
the
entire
workflow
from
perspective
visualization,
visual
analytics
integration.
Data
visualization
crucial
step
at
every
stage
workflow,
where
it
provides
core
components
inspection,
evaluation,
sharing
capabilities.
However,
due
large
number
available
analysis
corresponding
components,
hard
both
users
developers
get
an
overview
what
already
which
are
suitable
analysis.
addition,
there
little
cross-pollination
between
fields
leaving
be
designed
in
secondary
mostly
ad
hoc
fashion.
With
review,
aim
bridge
gap
visualization.
First,
introduce
as
topic
worthy
its
own
dedicated
research,
provide
primer
on
cutting-edge
into
well
active
metabolomics.
We
extend
discussion
best
practices
they
have
emerged
studies.
Second,
practical
roadmap
tool
landscape
use
within
field.
Here,
several
stages
commonly
used
strategies
examples.
context,
will
also
outline
promising
areas
further
development.
end
set
recommendations
how
make
visualizations
more
effective
transparent
communication
results.
Genome Biology and Evolution,
Год журнала:
2024,
Номер
16(8)
Опубликована: Авг. 1, 2024
During
de
novo
emergence,
new
protein
coding
genes
emerge
from
previously
nongenic
sequences.
The
proteins
they
encode
are
dissimilar
in
composition
and
predicted
biochemical
properties
to
conserved
proteins.
However,
functional
indeed
exist.
Both
identification
of
their
structural
characterization
experimentally
laborious.
To
identify
structured
silico,
we
applied
recently
developed
machine
learning
based
tools
found
that
most
different
both
structure
sequence.
some
adopt
known
folds,
participate
cellular
reactions,
form
biomolecular
condensates.
Apart
broadening
our
understanding
evolution,
study
also
provides
a
large
set
testable
hypotheses
for
focused
experimental
studies
on
function
Drosophila.
Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2655 - 2655
Опубликована: Ноя. 21, 2024
Gastrointestinal
cancers
(GIC),
encompassing
colonic,
rectal,
and
gastric
malignancies,
rank
among
the
most
prevalent
cancer
types
globally,
contributing
significantly
to
cancer-related
mortality.
In
scientific
literature,
various
syndromes
associated
with
colorectal
have
been
elucidated,
highlighting
intricate
interplay
between
genetic
factors
disease
manifestation.
The
primary
objective
of
this
study
was
conduct
a
exploration
aimed
at
elucidating
these
associations
identifying
shared
determinants
across
types.
Notably,
considerable
research
has
focused
on
KRAS
gene
mutations,
polymorphisms
in
nucleic
acids,
Wnt
signaling
pathway,
role
chemokine
ligands
tumorigenesis.
While
investigations
into
natural
plant
extracts
as
potential
therapeutic
agents
are
still
their
nascent
stages,
they
represent
promising
avenue
for
future
research.
Ongoing
studies
essential
uncover
suitable
biomarkers
that
could
facilitate
identification
understanding
links
GIC.
This
not
only
seeks
enhance
our
comprehension
underlying
architecture
but
also
aims
inform
development
targeted
therapies
preventive
strategies.
Natural Product Reports,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 2, 2024
Covering:
2014
to
2023
for
metabolomics,
2002
information
visualizationLC-MS/MS-based
untargeted
metabolomics
is
a
rapidly
developing
research
field
spawning
increasing
numbers
of
computational
tools
assisting
researchers
with
their
complex
data
processing,
analysis,
and
interpretation
tasks.
In
this
article,
we
review
the
entire
workflow
from
perspective
visualization,
visual
analytics
integration.
Data
visualization
crucial
step
at
every
stage
workflow,
where
it
provides
core
components
inspection,
evaluation,
sharing
capabilities.
However,
due
large
number
available
analysis
corresponding
components,
hard
both
users
developers
get
an
overview
what
already
which
are
suitable
analysis.
addition,
there
little
cross-pollination
between
fields
leaving
be
designed
in
secondary
mostly
ad
hoc
fashion.
With
review,
aim
bridge
gap
visualization.
First,
introduce
as
topic
worthy
its
own
dedicated
research,
provide
primer
on
cutting-edge
into
well
active
metabolomics.
We
extend
discussion
best
practices
they
have
emerged
studies.
Second,
practical
roadmap
tool
landscape
use
within
field.
Here,
several
stages
commonly
used
strategies
examples.
context,
will
also
outline
promising
areas
further
development.
end
set
recommendations
how
make
visualizations
more
effective
transparent
communication
results.
