A specific circuit in the midbrain detects stress and induces restorative sleep

Science, Год журнала: 2022, Номер 377(6601), С. 63 - 72

Опубликована: Июнь 30, 2022

In mice, social defeat stress (SDS), an ethological model for psychosocial stress, induces sleep. Such sleep could enable resilience, but how promotes is unclear. Activity-dependent tagging revealed a subset of ventral tegmental area γ-aminobutyric acid (GABA)-somatostatin (VTA

Язык: Английский

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Antagonistic circuits mediating infanticide and maternal care in female mice

Nature, Год журнала: 2023, Номер 618(7967), С. 1006 - 1016

Опубликована: Июнь 7, 2023

Язык: Английский

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Hypothalamic control of innate social behaviors

Science, Год журнала: 2023, Номер 382(6669), С. 399 - 404

Опубликована: Окт. 26, 2023

Sexual, parental, and aggressive behaviors are central to the reproductive success of individuals species survival thus supported by hardwired neural circuits. The behavior control column (RBCC), which comprises medial preoptic nucleus (MPN), ventrolateral part ventromedial hypothalamus (VMHvl), ventral premammillary (PMv), is essential for all social behaviors. RBCC integrates diverse hormonal metabolic cues adjusts an animal's physical activity, hence chance encounters. further engages mesolimbic dopamine system maintain interest reinforces actions that time-locked with We propose brainstem form a dual-control generating moment-to-moment actions. This Review summarizes recent progress regarding identities cells their pathways drive different aspects

Язык: Английский

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Microglia govern the extinction of acute stress-induced anxiety-like behaviors in male mice

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 10, 2024

Abstract Anxiety-associated symptoms following acute stress usually become extinct gradually within a period of time. However, the mechanisms underlying how individuals cope with to achieve extinction anxiety are not clear. Here we show that restraint causes an increase in activity GABAergic neurons CeA (GABA ) male mice, resulting anxiety-like behaviors 12 hours; meanwhile, elevated GABA neuronal CX3CL1 secretion via MST4 (mammalian sterile-20-like kinase 4)-NF-κB-CX3CL1 signaling consequently activates microglia CeA. Activated turn inhibit engulfment their dendritic spines, ultimately leading induced by stress. These findings reveal dynamic molecular and cellular mechanism which drive negative feedback activity, thus facilitating maintenance brain homeostasis response

Язык: Английский

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An ACC–VTA–ACC positive-feedback loop mediates the persistence of neuropathic pain and emotional consequences

Nature Neuroscience, Год журнала: 2024, Номер 27(2), С. 272 - 285

Опубликована: Янв. 3, 2024

Язык: Английский

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TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male mice

Neuron, Год журнала: 2024, Номер 112(11), С. 1795 - 1814.e10

Опубликована: Март 21, 2024

Язык: Английский

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Sexually dimorphic dopaminergic circuits determine sex preference

Science, Год журнала: 2025, Номер 387(6730)

Опубликована: Янв. 9, 2025

Sociosexual preference is critical for reproduction and survival. However, neural mechanisms encoding social decisions on sex remain unclear. In this study, we show that both male female mice exhibit but shift to when facing survival threats; their mediated by the dimorphic changes in excitability of ventral tegmental area dopaminergic (VTA DA ) neurons. males, VTA projections nucleus accumbens (NAc) mediate preference, those medial preoptic preference. females, firing-pattern (phasic-like versus tonic-like) alteration -NAc projection determines sociosexual preferences. These findings define neurons as a key node decision-making reveal sexually circuit underlying

Язык: Английский

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Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents

Science, Год журнала: 2025, Номер 387(6736)

Опубликована: Фев. 20, 2025

Whereas humans exhibit emergency responses to assist unconscious individuals, how nonhuman animals react unresponsive conspecifics is less well understood. We report that mice stereotypic behaviors toward or dead social partners, which escalate from sniffing and grooming more forceful actions such as mouth tongue biting pulling. The latter intense actions, prominent in familiar pairs, begin after prolonged immobility unresponsiveness cease when the partner regains activity. Their consequences, including improved airway opening clearance accelerated recovery unconsciousness, suggest rescue-like efforts. Oxytocin neurons hypothalamic paraventricular nucleus respond differentially presence of versus active their activation, along with oxytocin signaling, required for reviving-like actions. This tendency members may enhance group cohesion survival species.

Язык: Английский

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Parental Behavior in Rodents

Advances in neurobiology, Год журнала: 2022, Номер unknown, С. 1 - 53

Опубликована: Янв. 1, 2022

Язык: Английский

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A noradrenergic-hypothalamic neural substrate for stress-induced sleep disturbances

Proceedings of the National Academy of Sciences, Год журнала: 2022, Номер 119(45)

Опубликована: Ноя. 4, 2022

In our daily life, we are exposed to uncontrollable and stressful events that disrupt sleep. However, the underlying neural mechanisms deteriorating quality of non-rapid eye movement sleep (NREMs) REM largely unknown. Here, show in mice acute psychosocial stress disrupts by increasing brief arousals (microarousals [MAs]), reducing spindles, impairing infraslow oscillations spindle band electroencephalogram during NREMs, while REMs. This poor was reflected an increased number calcium transients activity noradrenergic (NE) neurons locus coeruleus (LC) NREMs. Opto- chemogenetic LC-NE activation naïve is sufficient change microarchitecture similar stress. Conversely, chemogenetically inhibiting reduced MAs NREMs normalized their after Specifically projecting preoptic area hypothalamus (POA) decreased enhanced spindles REMs Optrode recordings revealed stimulating fibers POA indeed suppressed spiking activated inactivated MAs. Our findings reveal changes dynamics stress-regulatory negatively affect quality, partially through interaction with POA.

Язык: Английский

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