Brain Behavior and Immunity, Год журнала: 2025, Номер unknown
Опубликована: Апрель 1, 2025
Язык: Английский
European Journal of Pharmacology, Год журнала: 2024, Номер 983, С. 176994 - 176994
Опубликована: Сен. 12, 2024
Язык: Английский
Процитировано
5
Cell Reports, Год журнала: 2025, Номер 44(2), С. 115253 - 115253
Опубликована: Янв. 30, 2025
Язык: Английский
Процитировано
0
Nature Communications, Год журнала: 2025, Номер 16(1)
Опубликована: Апрель 8, 2025
Clinical observation has identified cerebellar cognitive affective syndrome, which is characterized by various non-motor dysfunctions such as social disorders and anxiety. Increasing evidence revealed reciprocal mono-/poly-synaptic connections of cerebello-cerebral circuits, forming the concept connectome. In this study, we demonstrate that neurons in nuclei (CN) male mice project to a subset zona incerta (ZI) through long-range glutamatergic GABAergic transmissions, both capable encoding acute stress. Furthermore, activating or inhibiting transmissions CN → ZI pathway can positively negatively regulate anxiety place preference presynaptic plasticity-dependent mechanisms, well mediate motor-induced alleviation Our data support close relationship between cerebellum emotional processes suggest targeting outputs may be an effective approach for treating
Язык: Английский
Процитировано
0
Advances in neurotoxicology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Behavioral Neuroscience, Год журнала: 2024, Номер 18
Опубликована: Июль 17, 2024
Introduction Stress and trauma are significant risk factors for many neuropsychiatric disorders diseases, including anxiety disorders. Stress-induced symptoms have been attributed to enhanced excitability in circuits controlling fear, anxiety, aversion. A growing body of evidence has implicated GABAergic neurons the ventral tegmental area (VTA) aversion processing affective behavior. Methods We used an unpredictable footshock (uFS) model, together with electrophysiological behavioral approaches, investigate role VTA GABA anxiety-related behavior mice. Results One day after a single uFS session, C57BL/6J mice exhibited elevated neuron excitability. The was correlated increased glutamatergic input reduction postsynaptic signaling mediated via B receptors. Chemogenetic activation sufficient increase stress-naïve In addition, chemogenetic inhibition suppressed exposed uFS. Discussion These data show that early substrate stress-induced suggest approaches mitigating may hold promise treatment provoked by stress trauma.
Язык: Английский
Процитировано
4
Science Advances, Год журнала: 2025, Номер 11(2)
Опубликована: Янв. 10, 2025
Protein translation is crucial for fear extinction, a process vital adaptive behavior and mental health, yet the underlying cell-specific mechanisms remain elusive. Using Tet-On 3G genetic approach, we achieved precise temporal control over protein in infralimbic medial prefrontal cortex ( IL ) during extinction. In addition, our results reveal that disruption of cytoplasmic polyadenylation element binding 1 (Cpeb1) leads to notable alterations cell type–specific translational programs, thereby affecting Specifically, Cpeb1 deficiency neurons activates heterochromatin 3, which enhances microRNA networks, whereas microglia, it suppresses chemokine receptor Cx3cr1 ), resulting an aged-like microglial phenotype. These coordinated impair spine formation plasticity. Our study highlights critical role extinction provides insight into therapeutic targets disorders with deficits.
Язык: Английский
Процитировано
0
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Янв. 16, 2025
Abstract While CNS microglia have well-established roles in synapse pruning during neurodevelopment, only a few studies identified for formation. These focused on the cortex and primary sensory circuits restricted developmental time periods, leaving substantial gaps our understanding of early functions microglia. Here we investigated how absence impacts synaptic development nucleus accumbens (NAc), region critical emotional regulation motivated behaviors where dysfunction is implicated psychiatric disorders that arise life. Using genetically modified mouse lacks ( Csf1r ΔFIRE/ΔFIRE ), found blunted excitatory formation NAc. This effect was most prominent second third postnatal weeks, when previously to be overproduced, accompanied by an increase presynaptic release probability alterations postsynaptic kinetics. Tissue-level NAc proteomics confirmed microglial impacted numerous proteins involved structure, trans-synaptic signaling, pre-synaptic function. However, did not perturb levels astrocyte-derived cues adhesive promote synaptogenesis, suggesting reduced number may caused microglial-derived synaptogenic cue. Although observed electrophysiological changes were largely normalized adulthood, lasting effects threat avoidance behavior, these behavioral directly associated with neuronal activity. Together, results indicate role regulating landscape developing establishing functional underlying adult repertoires.
Язык: Английский
Процитировано
0
Journal of Affective Disorders, Год журнала: 2025, Номер 375, С. 49 - 63
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0
Frontiers in Psychiatry, Год журнала: 2025, Номер 15
Опубликована: Янв. 27, 2025
Stress is necessary for survival. However, chronic unnecessary stress exposure leads to cardiovascular, gastrointestinal and neuropsychiatric disorders. Thus, understanding the mechanisms involved in initiation maintenance of response essential since it may reveal underpinning pathophysiology these disorders aid development medication treat stress-mediated diseases. Pituitary adenylyl cyclase activating polypeptide (PACAP) its receptors (PAC1, VPAC1 VPAC2) are expressed hypothalamus other brain areas as well adrenal gland. Previous research has shown that this peptide/receptor system serves a modulator response. In addition modulating response, also be connected emerging role neuroprotective against hypoxia, ischemia, neurodegeneration. This article aims review literature regarding PACAP involvement different regions microglia PACAP-mediated modulation long-term adaptation recognizable clinically survival with resilience while manifested anxiety, depression neurobehavioral
Язык: Английский
Процитировано
0
Neurochemical Research, Год журнала: 2025, Номер 50(2)
Опубликована: Янв. 27, 2025
Язык: Английский
Процитировано
0