Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles

eLife, Год журнала: 2023, Номер 12

Опубликована: Фев. 28, 2023

The loss of a spouse is often cited as the most traumatic event in person’s life. However, for people, severity grief and its maladaptive effects subside over time via an understudied adaptive process. Like humans, socially monogamous prairie voles ( Microtus ochrogaster ) form opposite-sex pair bonds, upon partner separation, show stress phenotypes that diminish time. We test hypothesis extended separation diminishes bond-associated behaviors causes bond transcriptional signatures to erode. Opposite-sex or same-sex paired males were cohoused 2 weeks then either remained separated 48 hours 4 before collecting fresh nucleus accumbens tissue RNAseq. In separate cohort, we assessed partner-directed affiliation at these points. found persist despite prolonged both voles. bonding led changes accumbal transcription stably maintained while animals but eroded following separation. Eroded genes are associated with gliogenesis myelination, suggesting previously undescribed role glia loss. Further, pioneered neuron-specific translating ribosomal affinity purification Neuronally enriched revealed dopaminergic-, mitochondrial-, steroid hormone signaling-associated gene clusters sensitive acute disruption adaptation. Our results suggest erodes transcriptomic core behavioral features remaining intact, revealing potential molecular processes priming vole be able new bond.

Язык: Английский

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Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice

Nature Neuroscience, Год журнала: 2023, Номер 26(10), С. 1739 - 1750

Опубликована: Сен. 11, 2023

Язык: Английский

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A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System

Neuroscience Bulletin, Год журнала: 2024, Номер 40(10), С. 1573 - 1589

Опубликована: Июль 23, 2024

Язык: Английский

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Microglia as hunters or gatherers of brain synapses

Nature Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Дек. 11, 2024

Язык: Английский

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The molecular signals that regulate activity-dependent synapse refinement in the brain

Current Opinion in Neurobiology, Год журнала: 2023, Номер 79, С. 102692 - 102692

Опубликована: Фев. 17, 2023

Язык: Английский

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