The molecular signals that regulate activity-dependent synapse refinement in the brain DOI
Sivapratha Nagappan-Chettiar, Masahiro Yasuda, Erin Johnson‐Venkatesh

et al.

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 79, P. 102692 - 102692

Published: Feb. 17, 2023

Language: Английский

Prolonged partner separation erodes nucleus accumbens transcriptional signatures of pair bonding in male prairie voles DOI Creative Commons
Julie M. Sadino,

Xander G Bradeen,

Conor J. Kelly

et al.

eLife, Journal Year: 2023, Volume and Issue: 12

Published: Feb. 28, 2023

The loss of a spouse is often cited as the most traumatic event in person’s life. However, for people, severity grief and its maladaptive effects subside over time via an understudied adaptive process. Like humans, socially monogamous prairie voles ( Microtus ochrogaster ) form opposite-sex pair bonds, upon partner separation, show stress phenotypes that diminish time. We test hypothesis extended separation diminishes bond-associated behaviors causes bond transcriptional signatures to erode. Opposite-sex or same-sex paired males were cohoused 2 weeks then either remained separated 48 hours 4 before collecting fresh nucleus accumbens tissue RNAseq. In separate cohort, we assessed partner-directed affiliation at these points. found persist despite prolonged both voles. bonding led changes accumbal transcription stably maintained while animals but eroded following separation. Eroded genes are associated with gliogenesis myelination, suggesting previously undescribed role glia loss. Further, pioneered neuron-specific translating ribosomal affinity purification Neuronally enriched revealed dopaminergic-, mitochondrial-, steroid hormone signaling-associated gene clusters sensitive acute disruption adaptation. Our results suggest erodes transcriptomic core behavioral features remaining intact, revealing potential molecular processes priming vole be able new bond.

Language: Английский

Citations

20
Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice DOI
Tsai-Yi Lu,

Priyanka Hanumaihgari,

Eric T. Hsu

et al.

Nature Neuroscience, Journal Year: 2023, Volume and Issue: 26(10), P. 1739 - 1750

Published: Sept. 11, 2023

Language: Английский

Citations

17
A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System DOI

Zexuan Ma,

Wei Zhang, C. Wang

et al.

Neuroscience Bulletin, Journal Year: 2024, Volume and Issue: 40(10), P. 1573 - 1589

Published: July 23, 2024

Language: Английский

Citations

7
Microglia as hunters or gatherers of brain synapses DOI

Marta Pereira-Iglesias,

Joel Maldonado-Teixidó,

Alejandro Melero

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Language: Английский

Citations

6
The molecular signals that regulate activity-dependent synapse refinement in the brain DOI
Sivapratha Nagappan-Chettiar, Masahiro Yasuda, Erin Johnson‐Venkatesh

et al.

Current Opinion in Neurobiology, Journal Year: 2023, Volume and Issue: 79, P. 102692 - 102692

Published: Feb. 17, 2023

Language: Английский

Citations

15