Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Фев. 18, 2023
Abstract
A
pro-inflammatory
intestinal
microbiome
is
characteristic
of
Parkinson’s
disease
(PD).
Prebiotic
fibers
change
the
and
this
study
sought
to
understand
utility
prebiotic
for
use
in
PD
patients.
The
first
experiments
demonstrate
that
fermentation
patient
stool
with
increased
production
beneficial
metabolites
(short
chain
fatty
acids,
SCFA)
changed
microbiota
demonstrating
capacity
respond
favorably
prebiotics.
Subsequently,
an
open-label,
non-randomized
was
conducted
newly
diagnosed,
non-medicated
(
n
=
10)
treated
participants
wherein
impact
10
days
intervention
evaluated.
Outcomes
well
tolerated
(primary
outcome)
safe
(secondary
associated
biological
changes
microbiota,
SCFA,
inflammation,
neurofilament
light
chain.
Exploratory
analyses
indicate
effects
on
clinically
relevant
outcomes.
This
proof-of-concept
offers
scientific
rationale
placebo-controlled
trials
using
ClinicalTrials.gov
Identifier:
NCT04512599.
Protein & Cell,
Год журнала:
2023,
Номер
14(10), С. 713 - 725
Опубликована: Май 2, 2023
With
the
gradual
maturity
of
sequencing
technology,
many
microbiome
studies
have
published,
driving
emergence
and
advance
related
analysis
tools.
R
language
is
widely
used
platform
for
data
powerful
functions.
However,
tens
thousands
packages
numerous
similar
tools
brought
major
challenges
researchers
to
explore
data.
How
choose
suitable,
efficient,
convenient,
easy-to-learn
from
has
become
a
problem
researchers.
We
organized
324
common
classified
them
according
application
categories
(diversity,
difference,
biomarker,
correlation
network,
functional
prediction,
others),
which
could
help
quickly
find
relevant
analysis.
Furthermore,
we
systematically
sorted
integrated
(phyloseq,
microbiome,
MicrobiomeAnalystR,
Animalcules,
microeco,
amplicon)
analysis,
summarized
advantages
limitations,
will
appropriate
Finally,
thoroughly
reviewed
most
content
in
formed
suitable
pipeline
This
paper
accompanied
by
hundreds
examples
with
10,000
lines
codes
GitHub,
can
beginners
learn,
also
analysts
compare
test
different
sorts
providing
an
important
theoretical
basis
practical
reference
development
better
future.
All
code
available
at
GitHub
github.com/taowenmicro/EasyMicrobiomeR.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Фев. 18, 2023
Abstract
A
pro-inflammatory
intestinal
microbiome
is
characteristic
of
Parkinson’s
disease
(PD).
Prebiotic
fibers
change
the
and
this
study
sought
to
understand
utility
prebiotic
for
use
in
PD
patients.
The
first
experiments
demonstrate
that
fermentation
patient
stool
with
increased
production
beneficial
metabolites
(short
chain
fatty
acids,
SCFA)
changed
microbiota
demonstrating
capacity
respond
favorably
prebiotics.
Subsequently,
an
open-label,
non-randomized
was
conducted
newly
diagnosed,
non-medicated
(
n
=
10)
treated
participants
wherein
impact
10
days
intervention
evaluated.
Outcomes
well
tolerated
(primary
outcome)
safe
(secondary
associated
biological
changes
microbiota,
SCFA,
inflammation,
neurofilament
light
chain.
Exploratory
analyses
indicate
effects
on
clinically
relevant
outcomes.
This
proof-of-concept
offers
scientific
rationale
placebo-controlled
trials
using
ClinicalTrials.gov
Identifier:
NCT04512599.
