Food & Function,
Год журнала:
2024,
Номер
15(9), С. 4862 - 4873
Опубликована: Янв. 1, 2024
Intestinal
infections
are
strongly
associated
with
infant
mortality,
and
intestinal
immunoglobulin
A
(IgA)
is
important
to
protect
infants
from
after
weaning.
This
study
aims
screen
probiotics
that
can
promote
the
production
of
IgA
weaning
further
explore
their
potential
mechanisms
action.
In
this
study,
promoting
were
screened
in
weanling
mouse
models.
The
results
showed
oral
administration
Bifidobacterium
bifidum
(B.
bifidum)
FL228.1
FL276.1
significantly
enhanced
levels
small
intestine
upregulated
expression
a
proliferation-inducing
ligand
(APRIL)
its
upstream
regulatory
factor
toll-like
receptor
4
(TLR4).
Furthermore,
B.
relative
abundance
Lactobacillus,
while
increased
Marvinbryantia
decreased
Mucispirillum,
elevating
levels.
summary,
induce
tract
mice
by
APRIL
mediating
changes
gut
microbiota,
thus
playing
significant
role
enhancing
local
immunity
infants.
EMBO Molecular Medicine,
Год журнала:
2023,
Номер
15(8)
Опубликована: Июнь 6, 2023
Abstract
In
early
life,
the
intestinal
mucosa
and
immune
system
undergo
a
critical
developmental
process
to
contain
expanding
gut
microbiome
while
promoting
tolerance
toward
commensals,
yet
influence
of
maternal
diet
microbial
composition
on
offspring
maturation
remains
poorly
understood.
We
colonized
germ‐free
mice
with
consortium
14
strains,
fed
them
standard
fiber‐rich
chow
or
fiber‐free
diet,
then
longitudinally
assessed
development
during
weaning
period.
Unlike
pups
born
dams
fiber‐deprived
demonstrated
delayed
colonization
Akkermansia
muciniphila
,
mucin‐foraging
bacterium
that
can
also
use
milk
oligosaccharides.
The
exhibited
an
enrichment
colonic
transcripts
corresponding
defense
response
pathways
peak
in
Il22
expression
at
weaning.
Removal
A
.
from
community,
but
maintenance
was
associated
reduced
proportions
RORγt‐positive
innate
adaptive
cell
subsets.
Our
results
highlight
potent
dietary
fiber
intake
discrete
changes
postnatal
assemblage
development.
Cell Host & Microbe,
Год журнала:
2024,
Номер
32(6), С. 820 - 836
Опубликована: Июнь 1, 2024
Microbial
communities
that
colonize
the
human
gastrointestinal
(GI)
tract
defend
against
pathogens
through
a
mechanism
known
as
colonization
resistance
(CR).
Advances
in
technologies
such
next-generation
sequencing,
gnotobiotic
mouse
models,
and
bacterial
cultivation
have
enhanced
our
understanding
of
underlying
mechanisms
intricate
microbial
interactions
involved
CR.
Rather
than
being
attributed
to
specific
clades,
CR
is
now
understood
arise
from
dynamic
interplay
between
microbes
host
shaped
by
metabolic,
immune,
environmental
factors.
This
evolving
perspective
underscores
significance
contextual
factors,
encompassing
microbiome
composition
conditions,
determining
review
highlights
recent
research
has
shifted
its
focus
toward
elucidating
how
these
factors
interact
either
promote
or
impede
enteric
infections.
It
further
discusses
future
directions
unravel
complex
relationship
host,
microbiota,
determinants
safeguarding
GI
infections
health.
Seminars in Immunology,
Год журнала:
2024,
Номер
73, С. 101885 - 101885
Опубликована: Май 1, 2024
The
gut
microbiota
is
well
known
to
possess
immunomodulatory
capacities,
influencing
a
multitude
of
cellular
signalling
pathways
maintain
host
homeostasis.
Although
the
formation
immune
system
initiates
before
birth
in
sterile
environment,
an
emerging
body
literature
indicates
that
neonatal
influenced
by
first
wave
external
stimuli
includes
signals
from
maternal
microbiota.
A
second
stimulus
begins
after
and
must
be
tightly
regulated
during
period
when
colonization
occurs
concomitantly
with
maturation
system,
requiring
fine
adjustment
between
establishing
tolerance
towards
commensal
preserving
inflammatory
responses
against
pathogenic
invaders.
Besides
integrating
cues
microbes,
also
regulate
triggered
other
environmental
signals,
such
as
dietary
antigens,
which
become
more
complex
introduction
solid
food
weaning
period.
This
"window
opportunity"
early
life
thought
crucial
for
proper
development
setting
tone
subsequent
adulthood
modulating
risk
developing
chronic
metabolic
diseases.
Here
we
review
importance
host-microbiota
interactions
particularly
early-life
period,
highlighting
mechanisms
involved
communication.
discussion
focused
on
recent
data
demonstrating
microbiota-mediated
education
innate
cells
its
role
lymphoid
tissues.
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 616 - 616
Опубликована: Март 8, 2024
Autoimmune
diseases
are
complex
multifactorial
disorders,
and
a
mixture
of
genetic
environmental
factors
play
role
in
their
onset.
In
recent
years,
the
microbiota
has
gained
attention
as
it
helps
to
maintain
host
health
immune
homeostasis
is
relevant
player
interaction
between
our
body
outside
world.
Alterations
(dysbiosis)
its
composition
or
function
have
been
linked
different
pathologies,
including
autoimmune
diseases.
Among
functions,
there
activation/modulation
cells
that
can
protect
against
infections.
However,
if
dysbiosis
occurs,
compromise
host’s
ability
pathogens,
contributing
development
progression
some
cases,
infections
trigger
by
several
mechanisms,
alteration
gut
permeability
activation
innate
produce
pro-inflammatory
cytokines
recruit
autoreactive
T
B
cells.
this
scenario,
we
cannot
neglect
critical
hormones’
roles
regulating
responses.
Different
hormones,
especially
estrogens,
shown
influence
modulating
activity
system
ways.
review,
summarized
main
mechanisms
connection
infections,
microbiota,
immunity,
hormones
diseases’
onset
given
hormone
levels
on
pathogenesis.
detail,
focused
rheumatoid
arthritis,
multiple
sclerosis,
systemic
lupus
erythematosus.
The
mechanisms
of
how
host-microbe
mutualistic
relationships
are
established
at
weaning
contingently
upon
B-cell
surveillance
remain
inadequately
elucidated.
We
found
that
CD138+
plasmacyte
(PC)-mediated
promotion
IgA
response
regulates
the
symbiosis
between
Bacteroides
uniformis
(B.
uniformis)
and
host
during
period.
IgA-skewed
PCs
is
essential
for
B.
to
occupy
a
defined
gut
luminal
niche,
thereby
fostering
stable
colonization.
Furthermore,
within
natural
niche
was
perturbed
in
absence
IgA,
resulting
exacerbated
inflammation
IgA-deficient
mice
weaned
piglets.
Thus,
we
propose
priming
maintenance
intestinal
from
required
host-microbial
symbiosis,
whereas
perturbation
which
would
enhance
process.
Immunological Reviews,
Год журнала:
2024,
Номер
323(1), С. 303 - 315
Опубликована: Март 19, 2024
Besides
its
canonical
role
in
protecting
the
host
from
pathogens,
immune
system
plays
an
arguably
equally
important
maintaining
tissue
homeostasis.
Within
barrier
tissues
that
interface
with
external
microenvironment,
induction
of
tolerance
to
innocuous
antigens,
such
as
commensal,
dietary,
and
environmental
is
key
establishing
The
early
postnatal
period
represents
a
critical
window
opportunity
which
parallel
development
tissue,
cells,
microbiota
allows
for
reciprocal
regulation
shapes
long-term
immunological
tone
subsequent
risk
immune-mediated
diseases.
During
infancy,
appears
sacrifice
pro-inflammatory
functions,
prioritizing
establishment
tolerance.
In
this
review,
we
discuss
mechanisms
underlying
life
windows
intestinal
focus
on
newly
identified
RORγt
The
importance
of
the
microbiota
in
intestinal
tract
for
human
health
has
been
increasingly
recognized.
In
this
perspective,
microbiome
modulation,
a
targeted
alteration
microbial
composition,
gained
interest.
Phage
lysins,
peptidoglycan-degrading
enzymes
encoded
by
bacteriophages,
are
promising
new
class
antibiotics
currently
under
clinical
development
treating
bacterial
infections.
Due
to
their
high
specificity,
lysins
considered
microbiome-friendly.
This
review
explores
opportunities
and
challenges
using
as
modulators.
First,
specificity
endolysins,
which
can
be
further
modulated
protein
engineering
or
delivery
methods,
is
discussed.
Next,
obstacles
possible
solutions
assess
microbiome-friendliness
considered.
Finally,
lysin
discussed,
including
methods
such
particle-based
probiotic
vehicles.
Mapping
hurdles
developing
modulators
identifying
ways
overcome
these
help
development.
way,
application
innovative
antimicrobial
agents
expanded,
thereby
taking
full
advantage
characteristics.
