Fungicides, herbicides and bees: A systematic review of existing research and methods

PLoS ONE, Год журнала: 2019, Номер 14(12), С. e0225743 - e0225743

Опубликована: Дек. 10, 2019

Bees and the pollination services they deliver are beneficial to both food crop production, for reproduction of many wild plant species. Bee decline has stimulated widespread interest in assessing hazards risks bees from environment which live. While there is increasing knowledge on how use broad-spectrum insecticides agricultural systems may impact bees, little known about effects other pesticides (or protection products; PPPs) such as herbicides fungicides, used more widely than at a global scale. We adopted systematic approach review existing research potential impacts fungicides with aim identifying approaches determining gaps. acknowledging that herbicide can affect forage availability this focussed these compounds could have directly themselves. found most studies been carried out Europe USA, investigated honeybees. Furthermore, certain effects, those mortality, well represented literature comparison others, sub-lethal effects. More lab field, oral exposure frequently contact exposure. suggest number areas further improve base This will allow better assessment important inform future management decisions around sustainable PPPs.

Язык: Английский

---

Sweet solutions: nectar chemistry and quality

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2022, Номер 377(1853)

Опубликована: Май 2, 2022

Nectar, the main floral reward for pollinators, varies greatly in composition and concentration. The assumption that nectar quality is equivalent to its sugar (energy) concentration too simple. Diverse non-sugar components, especially amino acids secondary metabolites, play various roles nutrition health of pollinators. Many compounds have indirect effects by altering foraging behaviour pollinators or protecting them from disease. This review also emphasizes water component nectar, often ignored because evaporative losses difficulties sampling small volumes. Nectar properties vary with environmental factors, pollinator visits microbial contamination. Pollination mutualisms depend on ability insect vertebrate cope benefit variation diversity chemistry. article part theme issue 'Natural processes influencing health: chemistry landscapes'.

Язык: Английский

---

Fungicides and bees: a review of exposure and risk

Environment International, Год журнала: 2022, Номер 165, С. 107311 - 107311

Опубликована: Май 19, 2022

Fungicides account for more than 35% of the global pesticide market and their use is predicted to increase in future. While fungicides are commonly applied during bloom when bees likely foraging on crops, whether real-world exposure these chemicals - alone or combination with other stressors constitutes a threat health still subject great uncertainty. The first step estimating risks understand how what extent exposed active ingredients. Here we review current knowledge that exists about experience field, link quantitative data acute chronic risk lethal endpoints honey (Apis mellifera). From 702 publications screened, 76 studies contained residue detections bee matrices, further 47 provided qualitative information range taxa through various routes. We compiled 90 metabolites have been detected honey, beebread, pollen, beeswax, bodies bees. posed by fungicide residues was estimated EPA Risk Quotient (RQ) approach. Based concentrations pollen/beebread, none reported exceeded levels concern (LOC) set regulatory agencies risk, while 3 12 European Food Safety Authority (EFSA) LOC wild bees, respectively. When considering all most include many broad-spectrum systemic fungicides, as well widely used contact chlorothalonil. In addition providing detailed overview frequency environment, identified important research gaps suggest future directions move towards comprehensive understanding mitigation including synergistic co-exposure pesticides pathogens.

Язык: Английский

---

Effects of the Herbicide Glyphosate on Honey Bee Sensory and Cognitive Abilities: Individual Impairments with Implications for the Hive

Insects, Год журнала: 2019, Номер 10(10), С. 354 - 354

Опубликована: Окт. 18, 2019

The honeybee Apis mellifera is an important pollinator in both undisturbed and agricultural ecosystems. Its great versatility as experimental model makes it excellent proxy to evaluate the environmental impact of agrochemicals using current methodologies procedures toxicology. increase agrochemical use, including those that do not target insects directly, can have deleterious effects if carried out indiscriminately. This seems be case herbicide glyphosate (GLY), most widely used worldwide. presence honey has been reported samples obtained from different environments. Hence, understand its potential risks for this become essential only study on colonies located settings, but also under laboratory conditions. Subtle detected approaches. GLY negatively affects associative learning processes foragers, cognitive sensory abilities young hive bees promotes delays brood development. An integrated approach considers behavior, physiology, development allows determine eusocial insect perspective, infer putative disturbed environments where omnipresent.

Язык: Английский

---

CRAF Methylation by PRMT6 Regulates Aerobic Glycolysis–Driven Hepatocarcinogenesis via ERK‐Dependent PKM2 Nuclear Relocalization and Activation

Hepatology, Год журнала: 2019, Номер 71(4), С. 1279 - 1296

Опубликована: Авг. 30, 2019

Most tumor cells use aerobic glycolysis (the Warburg effect) to support anabolic growth and promote tumorigenicity drug resistance. Intriguingly, the molecular mechanisms underlying this phenomenon are not well understood. In work, using gain-of-function loss-of-function in vitro studies patient-derived organoid cell cultures as vivo positron emission tomography-magnetic resonance imaging animal models, we showed that protein arginine N-methyltransferase 6 (PRMT6) regulates human hepatocellular carcinoma (HCC) through nuclear relocalization of pyruvate kinase M2 isoform (PKM2), a key regulator effect.We found PRMT6 methylate CRAF at 100, interfering with its RAS/RAF binding potential, therefore altering extracellular signal-regulated (ERK)-mediated PKM2 translocation into nucleus. This altered PRMT6-ERK-PKM2 signaling axis was further confirmed both HCC mouse model endogenous knockout clinical samples. We also identified target hypoxia transcriptional repressor element 1-silencing transcription factor, linking driving glycolytic events. Finally, proof concept therapeutic potential 2-deoxyglucose, inhibitor, reverse sorafenib resistance mediated by deficiency HCC.Our findings indicate regulatory is an important determinant effect cells, provide mechanistic link among tumorigenicity, resistance, glucose metabolism.

Язык: Английский

---

Mixtures of an insecticide, a fungicide and a herbicide induce high toxicities and systemic physiological disturbances in winter Apis mellifera honey bees

Ecotoxicology and Environmental Safety, Год журнала: 2020, Номер 203, С. 111013 - 111013

Опубликована: Июль 21, 2020

Язык: Английский

---

Fungicide and insecticide exposure adversely impacts bumblebees and pollination services under semi-field conditions

Environment International, Год журнала: 2021, Номер 157, С. 106813 - 106813

Опубликована: Авг. 26, 2021

Sulfoximines, the next generation systemic insecticides developed to replace neonicotinoids, have been shown negatively impact pollinator development and reproduction. However, field-realistic studies on sulfoximines are few consequences pollination services unexplored. Moreover, impacts of other agrochemicals such as fungicides, their combined effects with remain poorly investigated. Here, we show in a full factorial semi-field experiment that spray applications both product Closer containing insecticide sulfoxaflor Amistar fungicide azoxystrobin, affected individual foraging performance bumblebees (Bombus terrestris). Insecticide exposure further reduced colony growth size whereas decreased pollen deposition. We found indications for resource limitation might exacerbated pesticide bumblebee colonies. Our work demonstrates can adversely before bloom may be insufficient mitigation measure prevent its negative pollinators. use during could reduce services.

Язык: Английский

---

Pollen nutrition fosters honeybee tolerance to pesticides

Royal Society Open Science, Год журнала: 2021, Номер 8(9), С. 210818 - 210818

Опубликована: Сен. 1, 2021

A reduction in floral resource abundance and diversity is generally observed agro-ecosystems, along with widespread exposure to pesticides. Therefore, a better understanding on how the availability quality of pollen diets can modulate honeybee sensitivity pesticides required. For that purpose, we evaluated toxicity acute chronic exposures field realistic higher concentrations azoxystrobin (fungicide) sulfoxaflor (insecticide) honeybees provided differing qualities (named S BQ pollens). We found intake reduced doses Contrary azoxystrobin, increased by 1.5- 12-fold bee mortality, which was intake. Most importantly, risk death upon high concentration significantly lower for diet when compared diet. This pesticide associated gene expression vitellogenin, glycoprotein promotes longevity, faster metabolization phytochemical p -coumaric acid, known upregulate detoxification enzymes. Thus, our study revealed influence ability bees metabolize withstand their detrimental effects, providing another strong argument restoration suitable foraging habitat.

Язык: Английский

---

The effects of glyphosate, pure or in herbicide formulation, on bumble bees and their gut microbial communities

The Science of The Total Environment, Год журнала: 2023, Номер 872, С. 162102 - 162102

Опубликована: Фев. 9, 2023

Язык: Английский

---

Metabolomics unveils the influence of dietary phytochemicals on residual pesticide concentrations in honey bees

Environment International, Год журнала: 2021, Номер 152, С. 106503 - 106503

Опубликована: Март 20, 2021

The losses of honey bee colonies and declines other insect pollinators have been associated with negative effects pesticides. Honey bees as well are nectar pollen foragers thus exposed to an extensive range phytochemicals. Understanding the synergistic, additive, antagonistic plant secondary metabolites pesticides in may help protect against agrochemicals. In this study, we used untargeted metabolomics investigate impact dietary phytochemical composition on residual concentration three pesticides: imidacloprid, tau-fluvalinate tebuconazole bees. were given different diets based or from four plants: Reseda odorata, Borago officinalis, Phacelia tanacetifolia, Trifolium repens for two days. Thereafter, they orally 10 ng/bee imidacloprid contact-exposed 0.9 μg/bee 5 tebuconazole. After 1 h oral exposure 24 contact exposure, anaesthetised CO2, sacrificed by freezing, extracted a validated QuEChERS method, pesticide concentrations determined LC-QTRAP-MS/MS. profiled UHPLC-Q Exactive-MS/MS. results revealed that has noteworthy influence correlation coefficient analysis demonstrated flavonoids reducing effect also highlighted impaired metabolism sugars Exploiting flavonoid-rich plants hold promise forage future beekeeping.

Язык: Английский

---