Tectonophysics, Год журнала: 2020, Номер 789, С. 228539 - 228539
Опубликована: Июнь 26, 2020
Язык: Английский
Nature Communications, Год журнала: 2020, Номер 11(1)
Опубликована: Май 8, 2020
Abstract Population structure is a key determinant in fostering cooperation among naturally self-interested individuals microbial populations, social insect groups, and human societies. Traditional research has focused on static structures, yet most real interactions are finite duration changing time, forming temporal network. This raises the question of whether can emerge persist despite an intrinsically fragmented population structure. Here we develop framework to study evolution networks. Surprisingly, find that network temporality actually enhances relative comparable networks, fact bursty interaction patterns generally impede cooperation. We resolve this tension by proposing measure quantify amount network, revealing intermediate level maximally boosts Our results open new avenue for investigating other emergent behaviours more realistic structured populations.
Язык: Английский
Процитировано
169
Fungal Diversity, Год журнала: 2021, Номер 109(1), С. 1 - 25
Опубликована: Июль 1, 2021
Язык: Английский
Процитировано
166
Virulence, Год журнала: 2021, Номер 12(1), С. 2509 - 2545
Опубликована: Окт. 6, 2021
Listeria monocytogenes is a saprophytic gram-positive bacterium, and an opportunistic foodborne pathogen that can produce listeriosis in humans animals. It has evolved exceptional ability to adapt stress conditions encountered different environments, resulting ubiquitous distribution. Because some food preservation methods disinfection protocols food-processing environments cannot efficiently prevent contaminations, L. constitutes threat human health challenge safety. In the host, colonizes gastrointestinal tract, crosses intestinal barrier, disseminates through blood target organs. immunocompromised individuals, elderly, pregnant women, cross blood-brain placental barriers, leading neurolisteriosis materno-fetal listeriosis. Molecular cell biology studies of infection have proven be versatile deploys unique strategies invade types, survive move inside eukaryotic host cell, spread from cell. Here, we present multifaceted life cycle comprehensive perspective. We discuss genetic features pathogenic species, analyze factors involved contamination, review bacterial tolerate stresses both during processing along host's tract. Then dissect host-pathogen interactions underlying listerial pathogenesis mammals systemic point view. Finally, summarize epidemiology, pathophysiology, clinical This work aims gather information fields crucial for understanding monocytogenes.
Язык: Английский
Процитировано
127
Journal of Molecular Liquids, Год журнала: 2021, Номер 349, С. 118108 - 118108
Опубликована: Ноя. 14, 2021
Язык: Английский
Процитировано
110
Frontiers in Microbiology, Год журнала: 2020, Номер 11
Опубликована: Май 19, 2020
Continuous contamination of the environment with xenobiotics and related recalcitrant compounds has emerged a serious threat pollution. Bioremediation is key to eliminate persistent contaminants from environment. The traditional bioremediation processes showed limitations, therefore, it necessary discover new technologies for best results. Here, in this review, we have provided an outlook on alternative strategies via synthetic biology, including exploring prerequisites analysis research data developing biological models microbial bioremediation. Moreover, cell coordination community, signaling, quorum sensing are engineered enhanced also described along promising gene editing tools obtaining host target sequences responsible degradation compounds. genetic circuit two-component regulatory system (TCRS) based biosensors detection briefly explained. These developments expected increase efficiency
Язык: Английский
Процитировано
137
Nature Communications, Год журнала: 2020, Номер 11(1)
Опубликована: Сен. 4, 2020
Abstract Due to their controlled size, sensitivity external stimuli, and ease-of-use, microgel colloids are unique building blocks for soft materials made by crosslinking polymers on the micrometer scale. Despite plethora of work published, many questions about internal structure, interactions, phase behavior still open. The reasons this lack understanding challenges arising from small size particles, complex pairwise solvent permeability. Here we describe pathways toward a complete based recent experimental advances in nanoscale characterization, such as super-resolution microscopy, scattering methods, modeling.
Язык: Английский
Процитировано
116
International Biodeterioration & Biodegradation, Год журнала: 2020, Номер 157, С. 105156 - 105156
Опубликована: Дек. 10, 2020
Язык: Английский
Процитировано
99
Scientific Reports, Год журнала: 2021, Номер 11(1)
Опубликована: Авг. 19, 2021
Abstract Flower based nanoparticles has gained a special attention as new sustainable eco-friendly avenue. Rosa floribunda charisma belongs to modern roses with bright yellow, red flowers marvellous rose scent. Different methods were used for the extraction of its floral scent such hexane, microwave, and solid-phase micro-extraction. The latter was most efficient method phenyl ethyl alcohol, unique roses. In current study, magnesium (RcNps) have been synthesized using petals that privileges beyond chemical physical routs. RcNps formation confirmed UV–Visible (UV–Vis) Spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), High Resolution-Transmission Electron Microscope (HR-TEM), Field Emission-Scanning (FE-SEM), Energy dispersive X-ray (EDX), Diffractometer (XRD), photoelectron spectroscopy (XPS). HR-TEM images detected polyhedral shape diverse size ranged within 35.25–55.14 nm. resulting exhibited high radical scavenging activity illustrated by inhibition superoxide, nitric oxide, hydroxyl xanthine oxidase IC 50 values 26.2, 52.9, 31.9 15.9 µg/ml respectively compared ascorbic acid. Furthermore, at concentration 100 significantly reduced (15.9 ± 0.61 µg/ml) acid (12.80 0.32 p < 0.05. Moreover, showed an excellent antiaging demonstrated collagenase, elastase, hyaluronidase tyrosinase enzymes in dose-dependent manner 58.7 1.66 µg/ml, 82.5 2.93 191.4 5.68 158.6 5.20 EGCG respectively. also, promising antibacterial against three skin pathogens delineate significant threat public health, Staphylococcus epidermidis , Streptococcus pyogenes Pseudomonas aeruginosa MIC 15.63, 7.81, 31.25 ciprofloxacin (7.81, 3.9 15.63 µg/ml). suppressed biofilms minimum biofilm inhibitory concentrations 1.95, 7.81 fore mentioned strains, Overall, our findings indicate could be leading natural source care cosmetic industry.
Язык: Английский
Процитировано
94
Geology, Год журнала: 2020, Номер 49(2), С. 150 - 155
Опубликована: Сен. 23, 2020
Abstract East African Rift System plate geometries and surface motions are some of the least constrained in context global motion models. In this study, we used GPS data to constrain Somalian rotation suggest a new tectonic geometry for region. addition, tested geologic from Southwest Indian Ridge on Madagascar determine refined kinematics Lwandle microplate. A zone broad deformation was discovered, extending eastern boundary Rovuma microplate, across Comoros Islands, including parts central northern Madagascar. is fragmenting, with southern rotating microplate piece south-central moving plate. Divergence Nubian-Somalian system involves both diffuse strain accommodation along narrow rift segments that bound rigid blocks.
Язык: Английский
Процитировано
90
Molecular Metabolism, Год журнала: 2021, Номер 51, С. 101222 - 101222
Опубликована: Март 27, 2021
Mitochondrial uncouplers are well-known for their ability to treat a myriad of metabolic diseases, including obesity and fatty liver diseases. However, many years now, mitochondrial have also been evaluated in diverse models cancer vitro vivo. Furthermore, some now clinical trials cancer, although none yet approved the treatment cancer. In this review we summarise published studies which investigated as an anti-cancer therapy preclinical models. cases, show strong effects both single agents, combination therapies, more toxic cells than normal cells. uncoupling mechanism action has described detail, with consistencies inconsistencies between different structural classes uncouplers. For example, decrease ATP levels disrupt key signalling pathways such AMPK/mTOR but on reactive oxygen species (ROS) production. Many these oppose aberrant phenotypes common that ultimately result cell death. We highlight several gaps knowledge need be addressed before clear direction strategy applying agents. There is large body evidence supporting therapeutic use long-term safety remains question it will critical identify patients types would benefit most from
Язык: Английский
Процитировано
88