Research progress in cell therapy for oral diseases: focus on cell sources and strategies to optimize cell function

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Март 7, 2024

In recent years, cell therapy has come to play an important therapeutic role in oral diseases. This paper reviews the active of mesenchymal stem cells, immune sources, and other cells disorders, presents data supporting including bone tooth regeneration, mucosal soft tissue defects, salivary gland dysfunction, orthodontic movement. The will first review progress optimization strategies for diseases, use hormones combination with gene-modified regulatory epigenetic regulation drug sheets/aggregates, cell-binding scaffold materials hydrogels, nanotechnology, 3D bioprinting cells. summary, we focus on exploration these different sources diseases application latest strategies.

Язык: Английский

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Non-invasive biomarkers for early diagnosis of Alzheimer’s disease in bodily fluids

S S Korsakov Journal of Neurology and Psychiatry, Год журнала: 2025, Номер 125(1), С. 8 - 8

Опубликована: Фев. 11, 2025

One of the urgent problems modern health care is Alzheimer’s disease (AD) and its early diagnosis. This due to rapid global spread AD, lack pathogenetic therapy, ability stabilize progression cognitive impairment in stages disease. Currently, only an autopsy can confirm diagnosis AD with 100% reliability, classical laboratory instrumental methods verification are difficult implement routine clinical practice several limitations. That why study new available biomarkers identified human bodily fluids promising for AD. The review addresses problem using markers fluids, which be obtained a non-invasive way. Potential saliva, tear fluid, urine, nasal secretion reviewed, their prognostic values as indicators stage evaluated.

Язык: Английский

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An Update of Salivary Biomarkers for the Diagnosis of Alzheimer’s Disease

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2059 - 2059

Опубликована: Фев. 26, 2025

Alzheimer's disease (AD) is characterized by progressive cognition and behavior impairments. Diagnosing AD early important for clinicians to slow down progression preserve brain function. Biomarkers such as tau protein amyloid-β peptide (Aβ) are used aid diagnosis clinical often lags. Additionally, biomarkers can be monitor status evaluate treatment. Clinicians detect these in the using positron emission tomography/computed tomography or cerebrospinal fluid a lumbar puncture. However, methods expensive invasive. In contrast, saliva collection simple, inexpensive, non-invasive, stress-free, repeatable. Moreover, damage parenchyma impact oral cavity some pathogenic molecules could travel back forth from mouth. This has prompted researchers explore saliva. Therefore, this study provides an overview of main finding salivary diagnosis. Based on available studies, Aβ, tau, cholinesterase enzyme activity, lactoferrin, melatonin, cortisol, proteomics, metabolomics, exosomes, microbiome were changed patients' when compared controls. well-designed studies essential confirm reliability validity diagnosing monitoring AD.

Язык: Английский

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Caries Status in People with Dementia: A Systematic Review

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(5), С. 1616 - 1616

Опубликована: Фев. 27, 2025

Background and Objective: People living with dementia typically have poor oral health. However, studies of caries status in this population revealed different results. This systematic review aimed to assess old adults dementia. Method: The PubMed, Web Science, Embase, Scopus databases were searched from inception 13 February 2025. Newcastle–Ottawa Scale (NOS) was used the risk bias case–control studies, Joanna Briggs Institute (JBI) Critical Appraisal Checklist cross-sectional studies. Caries measured by decayed, missing, filled teeth (DMFT) index, surfaces (DMFS) or component DMFT/S. A random effects model pool included data. weighted mean difference (WMD) 95% confidence interval (CI) calculated analyze effect on caries. Results: total 5363 retrieved, 20 study. Meta-analysis showed DMFT index (WMD: 3.76, p < 0.0001; studies), decayed (DT) 0.40, 10 missing (MT) 3.67, = 0.04; 7 studies) values higher group than control group. There no differences (FT) −0.66, 0.09; 9 between Conclusions: poorer people controls. These findings suggest that medical staff caregivers need pay more attention health patients.

Язык: Английский

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Fluid-based biomarkers for neurodegenerative diseases

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102739 - 102739

Опубликована: Март 1, 2025

Язык: Английский

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Salivary lactoferrin levels in Down Syndrome: a case-control study

Brain Behavior & Immunity - Health, Год журнала: 2025, Номер unknown, С. 100999 - 100999

Опубликована: Апрель 1, 2025

Язык: Английский

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The Protective Effect of Annexin A1 on Autophagy Via the CAMK2/BECN1 Signaling Pathway in PC12 Cells Stimulated with H2O2

Neurotoxicity Research, Год журнала: 2025, Номер 43(3)

Опубликована: Апрель 24, 2025

Язык: Английский

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Oxidation, Glycation, and Carbamylation of Salivary Biomolecules in Healthy Children, Adults, and the Elderly: Can Saliva Be Used in the Assessment of Aging?

Journal of Inflammation Research, Год журнала: 2022, Номер Volume 15, С. 2051 - 2073

Опубликована: Март 1, 2022

Aging is inextricably linked to oxidative stress, inflammation, and posttranslational protein modifications. However, no studies evaluate oxidation, glycation, carbamylation of salivary biomolecules as biomarkers aging. Saliva collection non-invasive, painless, inexpensive, which are advantages over other biofluids.The study enrolled 180 healthy subjects divided into six groups according age: 6-13, 14-19, 20-39, 40-59, 60-79, 80-100 years. The number individuals was determined a priori based on our previous experiment (power the test = 0.8; α 0.05). Non-stimulated saliva plasma were collected from participants, in aging by colorimetric, fluorometric, ELISA methods.The have demonstrated that modifications proteins increase with age, manifested decreased total thiol levels increased carbonyl groups, glycation (Nε-(carboxymethyl) lysine, advanced end products (AGE)) (carbamyl-lysine) old individuals. Oxidative lipids (4-hydroxynonenal) nucleic acids (8-hydroxy-2'-deoxyguanosine (8-OHdG)) also age. Salivary redox correlate poorly their levels; however, AGE 8-OHdG generally reflect blood concentrations. In multivariate regression model, they predictor and, receiver operating characteristic (ROC) analysis, significantly differentiate children adolescents (under 15 years old) working-age population (15-64 years) older people (65 older).Salivary most excellent diagnostic utility assessing process. can be used body.

Язык: Английский

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Salivary Xanthine Oxidase as a Potential Biomarker in Stroke Diagnostics

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Май 6, 2022

Stroke is one of the most common cerebrovascular diseases. Despite significant progress in understanding stroke pathogenesis, cases are still increasing. Thus, laboratory biomarkers sought to allow rapid and non-invasive diagnostics. Ischemia-reperfusion injury an inflammatory process with characteristic cellular changes leading microvascular disruption. Several studies have shown that hyperactivation xanthine oxidase (XO) a major pathogenic factor contributing brain dysfunction. Given critical role XO complications, this study aimed evaluate activity enzyme its metabolic products saliva subjects. Thirty patients subacute phase were included study: 15 hemorrhagic ischemic stroke. The control group consisted 30 healthy subjects similar cerebral regarding age, gender, status periodontium, dentition, oral hygiene. number individuals was determined priori based on our previous experiment (power test = 0.8; α 0.05). material mixed non‐stimulated whole (NWS) stimulated (SWS). We showed activity, specific output significantly higher NWS than controls. Hydrogen peroxide uric acid levels also considerably patients. Using receiver operating curve (ROC) analysis, we demonstrated XO-specific distinguishes from (AUC: 0.764) controls 0.973) very high sensitivity specificity. Saliva collection stress-free, requires no specialized medical personnel, allows continuous monitoring patient’s condition through sampling multiple times per day. Salivary differentiates accuracy (100%) specificity (93.75%) between mild moderate cognitive decline (AUC 0.988). salivary assessment may be potential screening tool for comprehensive neuropsychological evaluation. To summarize, demonstrates utility differential diagnosis

Язык: Английский

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Endogenous antioxidants predicted outcome and increased after treatment: A benzoate dose‐finding, randomized, double‐blind, placebo‐controlled trial for Alzheimer's disease

Psychiatry and Clinical Neurosciences, Год журнала: 2022, Номер 77(2), С. 102 - 109

Опубликована: Ноя. 6, 2022

Aim Previous pilot studies suggest that sodium benzoate may be a potential cognitive enhancer for patients with Alzheimer's disease (AD), schizophrenia, or late‐life depression. Especially AD treatment, confirmatory trial predictive biomarkers is urgently needed. This study aimed to confirm as novel treatment and discover its optimal dose biomarkers. Methods A 24‐week, dose‐finding, randomized, double‐blind, placebo‐controlled trial, clinical measurements at weeks 0, 8, 16, 24, was conducted in three major medical centers Taiwan. Among 154 screened AD, 149 were eligible randomized one of the four treatments: (i) 500 group (fixed mg/day); (ii) 750 (500 mg/day first 4 weeks, from 5th week); (iii) 1000 (iv) placebo. The primary outcome measure assessment scale‐cognitive subscale (ADAS‐cog). Results performed best improving ADAS‐cog ( P = 0.026 week 24), female advantage. Higher plasma catalase baseline predicted better outcome. Benzoate receivers tended have higher glutathione than placebo recipients after treatment. intervention groups showed similar safety profiles. Conclusions By enhancing two vital endogenous antioxidants, glutathione, therapy improved cognition predicting response. Supporting oxidative stress theory, results show promise AD.

Язык: Английский

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