Dysbiosis of pro‐inflammatory and anti‐inflammatory salivary cytokines during psoriasis providing a therapeutic window and a valuable diagnostic aid in future

Biotechnology and Applied Biochemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 13, 2024

The objective of this article is to evaluate the salivary levels tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin-2 (IL-2), and IL-10 in patients with active psoriasis compare them those healthy control subjects. This study included 60 subjects who were clinically diagnosed cases (categorized further into 33 mild moderate 27 severe based on Psoriasis Area Severity Index score) age- gender-matched Levels TNF-α, IFN-γ, IL-2, unstimulated saliva determined via enzyme-linked immunosorbent assay (BT Lab). IL-2 significantly higher, whereas concentration was reduced psoriatic comparison controls, difference increased progressing severity disease. Assessment cytokine profiles significant for diagnostic validation monitoring disease severity. Saliva offers an alternate, noninvasive, readily available biological sample evaluating levels. Extensive research field has been recommended better scientifically proven conclusions.

Язык: Английский

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Immune Dysregulation in the Oral Cavity during Early SARS-CoV-2 Infection

Journal of Dental Research, Год журнала: 2024, Номер 103(12), С. 1258 - 1270

Опубликована: Окт. 12, 2024

Tissue-specific immune responses are critical determinants of health-maintaining homeostasis and disease-related dysbiosis. In the context COVID-19, oral reflect local host-pathogen dynamics near site infection serve as important “windows to body,” reflecting systemic invading SARS-CoV-2 virus. This study leveraged multiplex technology characterize salivary SARS-CoV-2–specific immunological landscape (37 cytokines/chemokines 11 antibodies) during early infection. Cytokine/immune profiling was performed on unstimulated cleared whole saliva collected from 227 adult SARS-CoV-2+ participants 37 controls. Statistical analysis modeling revealed significant differential abundance 25 cytokines (16 downregulated, 9 upregulated). Pathway demonstrated is associated with suppression type I/III interferon blunted natural killer–/T-cell responses, a potential novel immune-evasion strategy enabling virus-associated occurred concomitantly upregulation proinflammatory pathways including marked increases in acute phase proteins pentraxin-3 chitinase-3-like-1. Irrespective infection, prior vaccination increased total α-SARS-CoV-2-spike (trimer), -S1 protein, -RBD, -nucleocapsid antibodies, highlighting importance COVID-19 eliciting mucosal responses. Altogether, our findings highlight stable accessible biofluid for monitoring host over time suggest that oral-mucosal dysregulation hallmark possible implications viral evasion mechanisms.

Язык: Английский

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Biomarkers of Cardiovascular Diseases in Saliva and Gingival Crevicular Fluid: A Review

Angiology, Год журнала: 2022, Номер 74(10), С. 909 - 947

Опубликована: Окт. 21, 2022

Due to the fact that cardiovascular diseases (CVDs) have become most serious problem in public health, there is a need for new and efficient methods screening early detection. In recent literature, saliva gingival crevicular fluid (GCF) been gaining recognition as sources of many potential biomarkers various systemic diseases, mainly because correlation between level some compounds blood association composition health status. this review, we summarize published findings patients with atherosclerosis, arterial hypertension, coronary artery disease (CAD), acute syndrome (ACS), stroke context clinical utility GCF diagnosing assessing CVD severity. We hypothesize substances including inflammatory markers, enzymes, or hormones might novel contributors diagnosis CVDs. particular, C-reactive protein (CRP), tumor necrosis alpha (TNFα), cortisol seem be promising. However, further investigation warranted determine effective markers their analysis.

Язык: Английский

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Salivary inflammatory burden in pre‐ and postmenopausal women: Associations with body mass index, patient‐reported health, serum cytokines, and periodontal parameters

Journal of Periodontology, Год журнала: 2023, Номер 95(3), С. 209 - 218

Опубликована: Июль 19, 2023

The decline of estrogen levels during menopause impacts weight, mood, and overall health, both orally systemically. This study assessed salivary tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6), IL-10, IL-7 in postmenopausal (PMW) regularly menstruating premenopausal (RMPW) women, while considering serum cytokine levels, body mass index (BMI), periodontal self-reported physical emotional well-being.

Язык: Английский

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The diagnostic and prognostic value of serum neurogranin in acute ischemic stroke

Journal of Stroke and Cerebrovascular Diseases, Год журнала: 2022, Номер 32(2), С. 106889 - 106889

Опубликована: Дек. 6, 2022

Язык: Английский

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