Trauma
exposure
is
prevalent
globally
and
a
defining
event
for
the
development
of
posttraumatic
stress
disorder
(PTSD),
characterised
by
intrusive
thoughts,
avoidance
behaviours,
hypervigilance
negative
alterations
in
cognition
mood.
Exposure
to
trauma
elicits
range
physiological
responses
which
can
interact
with
environmental
factors
confer
relative
risk
or
resilience
PTSD.
This
systematic
review
summarises
findings
longitudinal
studies
examining
biological
correlates
predictive
PTSD
symptomology.
Databases
(Pubmed,
Scopus
Web
Science)
were
systematically
searched
using
relevant
keywords
published
between
1
January
2021
31
December
2022.
English
language
included
if
they
original
research
manuscripts
meta-analyses
cohort
investigations
that
assessed
relationships
one
more
molecular-level
measures
either
status
symptoms.
Eighteen
1,042
records
identified
included.
Studies
primarily
military
veterans/personnel,
individuals
admitted
hospitals
after
acute
traumatic
injury,
women
exposed
interpersonal
violence
rape.
Genomic,
inflammation
endocrine
most
commonly
molecular
markers
highlighted
processes
related
inflammation,
responding,
learning
memory.
Quality
assessments
done
Systematic
Appraisal
Observational
Research,
majority
rated
as
being
high
quality,
remainder
moderate
quality.
predominantly
conducted
upper-income
countries.
Those
performed
low-
middle-income
countries
not
broadly
representative
terms
demographic,
type
geographic
profiles,
three
out
four
assessing
only
female
participants,
rape
South
Africa,
respectively.
They
also
did
generate
multimodal
data
use
machine
multilevel
modelling,
potentially
reflecting
greater
resource
limitations
LMICs.
Research
contributions
does
adequately
reflect
global
burden
disorder.
Post-traumatic
stress
disorder
(PTSD)
is
a
psychiatric
that
causes
debilitating
functional
impairment
in
patients.
Observations
from
survivors
of
traumatic
historical
events
solidify
this
disease
not
only
associated
with
personal
experiences
but
can
also
be
inherited
familial
traumas.
Over
the
past
decades,
researchers
have
focused
on
epigenetic
inheritance
to
understand
how
responses
adverse
passed
down
future
generations.
This
review
aims
present
recent
findings
markers
related
PTSD
and
research
intergenerational
trauma.
By
understanding
information,
we
hope
act
as
biochemical
measurements
for
clinical
practice.
Frontiers in Psychiatry,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 7, 2022
Epigenetic
research
in
post-traumatic
stress
disorder
(PTSD)
is
essential,
given
that
environmental
stressors
and
fear
play
such
a
crucial
role
its
development.
As
such,
it
may
provide
framework
for
understanding
individual
differences
the
prevalence
of
treatment
response.
This
paper
reviews
epigenetic
markers
associated
with
PTSD
treatment,
including
candidate
genes
epigenome-wide
studies.
Because
etiopathogenesis
rests
heavily
on
learning
memory,
we
also
draw
upon
animal
neuroepigenetic
acquisition,
update
erasure
focusing
mechanisms
memory
reconsolidation.
Reconsolidation
blockade
(or
impairment)
has
been
studied
clinical
trials
and,
from
neurological
perspective,
hold
promise
identifying
successful
therapy.
We
conclude
this
by
discussing
several
key
considerations
challenges
humans.
Scientific Reports,
Год журнала:
2022,
Номер
12(1)
Опубликована: Окт. 20, 2022
Abstract
Adverse
childhood
experiences
(ACEs,
i.e.,
abuse,
neglect,
household
dysfunction)
represent
a
potential
risk
factor
for
wide
range
of
long-lasting
diseases
and
shorter
life
expectancy.
We
recently
described
1-week
residential
group
program,
based
on
mindfulness
training,
artistic
expression
EMDR
therapy,
that
significantly
reduced
PTSD-related
symptoms
increased
attention/awareness-related
outcomes
in
adolescent
girls
with
multiple
ACEs
randomized
controlled
study.
Since
epigenetic
mechanisms
(i.e.,
DNA
methylation)
have
been
associated
the
effects
ACEs,
present
report
extends
these
prior
findings
by
exploring
genome-wide
methylation
changes
following
program.
Saliva
samples
from
all
participants
(n
=
44)
were
collected
genomic
was
extracted
(T1)
(T2)
intervention.
Genome-wide
analysis
using
MethylationEPIC
beadchip
array
(Illumina)
revealed
49
differentially
methylated
loci
(DML;
p
value
<
0.001;
change
>
10%)
annotated
to
genes
roles
biological
processes
linked
early
adversity
neural,
immune,
endocrine
pathways,
cancer
cardiovascular
disease).
sequences
flanking
DML
showed
significant
enrichment
transcription
binding
sites
involved
inflammation,
cancer,
disease,
brain
development.
Methylation
SIRT5
TRAPPC2L
associations
trauma-related
psychological
measures.
Results
presented
here
suggest
this
multimodal
program
adolescents
victimization
modulates
methylome
at
relevance
health
behavioral
disorders
ACEs.
International Journal of Translational Medicine,
Год журнала:
2024,
Номер
4(3), С. 450 - 462
Опубликована: Июль 11, 2024
It
is
well
known
that
mental
illness
often
the
result
of
genetic
susceptibility
combined
with
environmental
factors.
In
this
context,
it
useful
to
consider
role
changes
in
DNA
expression,
as
epigenetic,
can
play
development
and
progression
psychiatric
disorders.
Accordingly,
psychotherapy,
a
form
pharmacological
strategy
targets
dysfunctional
emotions
behaviors,
may
also
improve
symptoms
via
epigenetic
changes.
This
article
reviews
current
literature
on
induced
by
psychotherapy
disorders,
pointing
out
encouraging
findings
for
borderline
personality
disorder
(BPD),
post-traumatic
stress
(PTSD),
anxiety
disorders
obsessive–compulsive
(OCD).
focuses
genes
are
more
commonly
associated
paves
way
further
research.
European journal of psychotraumatology,
Год журнала:
2023,
Номер
14(2)
Опубликована: Июль 5, 2023
Background:
War-related
trauma
is
associated
with
varying
posttraumatic
stress
disorder
(PTSD)
prevalence
rates
in
refugees.
In
PTSD
development,
differential
DNA
methylation
(DNAm)
levels
exposure
might
be
involved
risk
versus
resilience
processes.
Studies
investigating
DNAm
profiles
related
to
and
among
refugees
remain
sparse.Objective:
The
present
epigenome-wide
association
study
investigated
associations
between
war-related
trauma,
PTSD,
altered
patterns
Burundian
refugee
families
110
children
their
207
female
male
caregivers.Method:
load
symptom
severity
were
assessed
structured
clinical
interviews
standardised
instruments.
Epigenome-wide
quantified
from
buccal
epithelia
using
the
Illumina
EPIC
beadchip.Results:
Controlling
for
biological
confounders,
no
significant
alterations
or
identified
caregivers
(FDRs
>
.05).
Co-methylated
positions
derived
as
modules
weighted
gene
correlation
network
analyses
not
significantly
either
experience
PTSD.Conclusions:
These
results
do
provide
evidence
PTSD.
Cambridge Prisms Global Mental Health,
Год журнала:
2023,
Номер
10
Опубликована: Янв. 1, 2023
Abstract
Trauma
exposure
is
prevalent
globally
and
a
defining
event
for
the
development
of
posttraumatic
stress
disorder
(PTSD),
characterised
by
intrusive
thoughts,
avoidance
behaviours,
hypervigilance
negative
alterations
in
cognition
mood.
Exposure
to
trauma
elicits
range
physiological
responses
which
can
interact
with
environmental
factors
confer
relative
risk
or
resilience
PTSD.
This
systematic
review
summarises
findings
longitudinal
studies
examining
biological
correlates
predictive
PTSD
symptomology.
Databases
(Pubmed,
Scopus
Web
Science)
were
systematically
searched
using
relevant
keywords
published
between
1
January
2021
31
December
2022.
English
language
included
if
they
original
research
manuscripts
meta-analyses
cohort
investigations
that
assessed
relationships
one
more
molecular-level
measures
either
status
symptoms.
Eighteen
1,042
records
identified
included.
Studies
primarily
military
veterans/personnel,
individuals
admitted
hospitals
after
acute
traumatic
injury,
women
exposed
interpersonal
violence
rape.
Genomic,
inflammation
endocrine
most
commonly
molecular
markers
highlighted
processes
related
inflammation,
responding,
learning
memory.
Quality
assessments
done
Systematic
Appraisal
Observational
Research,
majority
rated
as
being
high
quality,
remainder
moderate
quality.
predominantly
conducted
upper-income
countries.
Those
performed
low-
middle-income
countries
not
broadly
representative
terms
demographic,
type
geographic
profiles,
three
out
four
assessing
only
female
participants,
rape
South
Africa,
respectively.
They
also
did
generate
multimodal
data
use
machine
multilevel
modelling,
potentially
reflecting
greater
resource
limitations
LMICs.
Research
contributions
does
adequately
reflect
global
burden
disorder.
Conflicts
and
wars,
particularly
prevalent
in
regions
such
as
Africa,
the
Middle
East
Asia,
have
profound
multifaceted
effects
on
individuals,
spanning
socioeconomic,
medical
psychological
realms.
The
present
review
delves
into
intricate
interplay
between
genetics,
epigenetics
experiences
of
children,
conflict
zones.
Genetics,
study
inherited
traits,
epigenetics,
how
environmental
factors
influence
gene
expression,
jointly
shape
development
response
to
trauma
an
individual.
While
traditionally,
genes
were
considered
sole
determinants
epigenetic
modifications
reveal
significant
role
factors.
Children
war
zones
are
vulnerable,
suffering
from
a
myriad
physical
traumas,
including
post‑traumatic
stress
disorder
depression.
Moreover,
exposure
violence
during
critical
developmental
periods
can
transgenerational
effects,
affecting
mental
health
subsequent
generations.
Recent
research
highlights
changes
individuals
affected
by
historical
Holocaust,
demonstrating
parental
offspring.
Interventions
targeting
mechanisms
show
promise
mitigating
trauma.
Narrative
therapy
other
interventions
been
shown
induce
associated
with
memory
processing,
offering
hope
for
individuals.
Additionally,
influences
periods,
famine
adolescence,
linked
long‑term
outcomes,
risk
developing
colorectal
cancer.
Herein,
shaping
individual
responses
is
underscore.
Further
larger
scale
warranted
validate
expand
upon
these
findings,
insight
potential
avenues
intervention
support
conflict‑related
