Association between glucose metabolism, the circadian cycle and hypoxia: Evaluation of the NPAS2 and Rev-Erb-α protein serum levels in obstructive sleep apnea patients – a pilot study

Dental and Medical Problems, Год журнала: 2024, Номер 61(3), С. 465 - 469

Опубликована: Май 28, 2024

Background.Obstructive sleep apnea (OSA) is one of the risk factors for diabetes mellitus type 2 (DM2).As OSA associated with disruption circadian rhythm, it affects clock proteins, including neuronal PAS domain protein (NPAS2) and nuclear receptor subfamily 1 group D member (Rev-Erb-α).These proteins have been shown to be related metabolic abnormalities, i.a., insulin resistance.Objectives.The present pilot study aimed investigate NPAS2 Rev-Erb-α serum levels in groups patients severe OSA+DM2 comparison healthy controls, taking into account correlations polysomnography (PSG) parameters (e.g., oxygen saturation (SpO ) variables). Material methods.A total 40 participants were included study.They split 3 as follows: (n = 17; apnea-hypopnea index (AHI) >30, no DM2); 7; AHI > 30 control 16; < 5, DM2).All underwent a nocturnal PSG examination had their blood collected following morning.The assessed using enzyme-linked immunosorbent assay (ELISA). Results.The mean level was significantly lower compared individuals (p 0.017).Additionally, presented group, but only tendency observed 0.094).No differences concentration noticed.Furthermore, negative correlation between during rapid eye movement (REM) (r -0.478;p 0.002).Conclusions.Serum might involved dysregulation among patients, while mechanism itself may REM sleep.

Язык: Английский

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Endocrine toxicity of atrazine and its underlying mechanisms

Toxicology, Год журнала: 2024, Номер 505, С. 153846 - 153846

Опубликована: Май 28, 2024

Язык: Английский

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Revisiting the Role of Serotonin in Sleep-Disordered Breathing

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1483 - 1483

Опубликована: Янв. 25, 2024

Serotonin or 5-hydroxytryptamine (5-HT) is a ubiquitous neuro-modulator–transmitter that acts in the central nervous system, playing major role control of breathing and other physiological functions. The midbrain, pons, medulla regions contain several serotonergic nuclei with distinct roles, including regulating hypercapnic ventilatory response, upper airway patency, sleep–wake states. Obesity risk factor development sleep-disordered (SDB), such as obstructive sleep apnea (OSA), recurrent closure during sleep, obesity hypoventilation syndrome (OHS), condition characterized by daytime hypercapnia sleep. Approximately 936 million adults have OSA, 32 OHS worldwide. 5-HT on receptor subtypes modulate neural patency. This article reviews SDB current advances 5-HT-targeted treatments for SDB.

Язык: Английский

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Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(6), С. 3160 - 3160

Опубликована: Март 9, 2024

The relationship between sleep, glial cells, and the endocannabinoid system represents a multifaceted regulatory network with profound implications for neuroinflammation cognitive function. molecular underpinnings of sleep modulation by its influence on cell activity are discussed, shedding light reciprocal relationships that govern these processes. Emphasis is placed understanding role cells in mediating neuroinflammatory responses their patterns. Additionally, this review examines how interfaces glia-immune signaling to regulate inflammatory cascades within central nervous system. Notably, consequences disrupted neuroinflammation, dysfunction addressed, encompassing neurodegenerative disorders, mood disturbances, decline. Insights into bidirectional function context explored, providing comprehensive perspective potential mechanisms underlying impairments associated disturbances. Furthermore, therapeutic avenues targeting mitigate restore homeostasis, normalize identification novel targets intricate holds promise addressing conditions characterized dysfunction. This work aims examine complexities neural regulation identify intervention.

Язык: Английский

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The Influence of Serotonergic Signaling on Quality of Life, Depression, Insomnia, and Hypoxia in Obstructive Sleep Apnea Patients: Cross-Sectional Study

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 445 - 445

Опубликована: Янв. 12, 2025

Background/Objectives: Serotonin and the serotonin transporter (SERT) may have a multifaceted, but not fully understood, role in obstructive sleep apnea (OSA) its impact on mental health this group of patients. This study aimed to investigate changes their association with depressive insomnia symptoms. Methods: included 76 participants (OSA group: n = 36, control (CG): 40) who underwent polysomnography, while venous blood samples (evening morning) were analyzed for SERT using ELISA. mRNA expression peripheral leukocytes was measured via quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Participants evaluated depression, insomnia, quality life (QoL). Results: found no significant differences or between OSA CG. In CG, individuals without mood disorders had higher baseline levels evening/morning ratios than those depression. Among participants, good QoL elevated evening (p 0.028) morning 0.043) compared poor QoL. Baseline protein CG group. Linear regression models showed 13.3% 13.1% non-rapid eye movement (NREM) apnea/hypopnea index (AHI) AHI variability, respectively, which accounted by level, 30.8% arousal variability explained level. Conclusions: Serotonergic signaling influence life, OSA, as well severity disease itself. Stratifying patients clinical laboratory phenotypes could enable more personalized treatment.

Язык: Английский

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Serotonergic psychedelics as potential therapeutics for post-COVID-19 syndrome (or Long COVID): A comprehensive review

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2025, Номер unknown, С. 111279 - 111279

Опубликована: Фев. 1, 2025

Язык: Английский

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Association between sleep bruxism and snoring in adults: An observational study

Sleep Medicine, Год журнала: 2024, Номер 124, С. 276 - 281

Опубликована: Сен. 12, 2024

Язык: Английский

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Impact of CPAP Therapy on Cognition and Fatigue in Patients with Moderate to Severe Sleep Apnea: A Longitudinal Observational Study

Clocks & Sleep, Год журнала: 2024, Номер 6(4), С. 789 - 816

Опубликована: Дек. 23, 2024

Continued solicitation of cognitive resources eventually leads to fatigue (CF), i.e., a decrease in efficiency that develops during sustained demands conditions constrained processing time, independently sleepiness. The expression CF and its impact on cognition are partly contingent upon prior sleep quality restorative effects. Sleep obstructive apnea (OSA) may be largely restored through the use continuous positive airway pressure (CPAP) treatment, contributing gradual improvement quality. In this longitudinal observational study, we investigated immediate longer-term behavioral effects CPAP treatment functioning, evaluating outcomes after initiation at three six months, compliant CPAP-treated OSA patients. Results indicate therapy significantly enhances subjective functions, including episodic memory, inhibition, attention, working executive control. Noticeable performance improvements were observed CF-inducing tasks, particularly months use. Participants also reported substantial gains life, reduced daytime sleepiness, improved mood. These results confirm not only alleviates physiological disturbances associated with OSA, but supports recovery enhanced overall daily functioning.

Язык: Английский

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Shedding light on neurofilament involvement in cognitive decline in obstructive sleep apnea and its possible role as a biomarker

Frontiers in Psychiatry, Год журнала: 2023, Номер 14

Опубликована: Ноя. 30, 2023

Obstructive sleep apnea is one of the most common disorders with a high estimated global prevalence and large number associated comorbidities in general as well specific neuropsychiatric complications such cognitive impairment. The complex pathogenesis effects disorder including chronic intermittent hypoxia fragmentation may lead to enhanced neuronal damage, thereby contributing pathologies. has been described an independent risk factor for several neurodegenerative diseases, Alzheimer's disease all-cause dementia. influence obstructive on deficits still topic recent debate, mechanisms, neurodegeneration depression-related dysfunction, underlying this correlation are taken into consideration. differentiation between both pathomechanisms impairment clinical issue, requiring use multiple costly diagnostic methods. studies conducted neuroprotection biomarkers, brain-derived neurotrophic factors neurofilaments, recently gaining ground cognition assessment patients. Neurofilaments neuron-specific cytoskeletal proteins could be useful non-invasive indicators brain conditions neurodegeneration, which already observed many neurological diseases leading deficits. Additionally, neurofilaments play important role biomarker other insomnia. Thus, review summarizes current knowledge involvement decline patients discusses its possible these changes.

Язык: Английский

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Association of Sleep Pattern and Genetic Susceptibility with Obstructive Sleep Apnea: A Prospective Analysis of the UK Biobank

Nature and Science of Sleep, Год журнала: 2024, Номер Volume 16, С. 503 - 515

Опубликована: Май 1, 2024

Purpose: The prevalence of obstructive sleep apnea (OSA) is high worldwide. This study aimed to quantify the relationship between incidence OSA and patterns genetic susceptibility. Methods: A total 355,133 white British participants enrolled in UK Biobank 2006 2010 with follow-up data until September 2021 were recruited. We evaluated using a customized scoring method based on low-risk phenotype, defined as follows: morning chronotype, 7– 8 hours per day, never/rarely experience insomnia, no snoring, frequent daytime sleepiness, nap, easily getting up early. polygenic risk score was calculated assess susceptibility OSA. Cox proportional hazard models used evaluate associations Results: During mean 12.57 years, 4618 diagnosed (age: 56.83 ± 7.69 women: 31.3%). Compared those poor pattern, normal (HR: 0.42, 95% CI: 0.38– 0.46), ideal 0.21, 0.19– 0.24), or optimal 0.15, 0.12– 0.18) pattern significantly more likely have 173,239 calculated, results showed that 3.67, 2.95– 4.57) 1.89, 1.66– 2.16) can increase for Conclusion: large-scale prospective provides evidence suggesting across seven phenotypes may protect against individuals varying degrees Keywords: apnea, healthy score, susceptibility,

Язык: Английский

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