Long COVID: a clinical update

The Lancet, Год журнала: 2024, Номер 404(10453), С. 707 - 724

Опубликована: Июль 31, 2024

Язык: Английский

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Autonomic cardiac function in children and adolescents with long COVID: a case-controlled study

European Journal of Pediatrics, Год журнала: 2024, Номер 183(5), С. 2375 - 2382

Опубликована: Март 6, 2024

Although the mechanisms underlying pathophysiology of long COVID condition are still debated, there is growing evidence that autonomic dysfunction may play a role in long-term complications or persisting symptoms observed significant proportion patients after SARS-CoV-2 infection. However, studies focused on have primarily been conducted adults, while function has not yet investigated pediatric subjects. In this study, for first time, we assessed whether with present abnormalities cardiac function. Fifty-six (mean age 10.3 ± 3.8 y) and 27 age-, sex-, body surface area-matched healthy controls 10.4 4.5y) underwent standard 12-lead electrocardiography (ECG) 24-h ECG Holter monitoring. Autonomic was by time-domain frequency-domain heart rate variability parameters. A comprehensive echocardiographic study also obtained two-dimensional echocardiography tissue Doppler imaging. Data analysis showed had changes HRV variables compared to controls: significantly lower r-MSSD (root mean square successive RR interval differences, 47.4 16.9 versus 60.4 29.1, p = 0.02), higher values VLF (very low frequency, 2077.8 1023.3 494.3 1015.5 ms, 0.000), LF (low 1340.3 635.6 354.6 816.8 HF (high 895.7 575.8 278.9 616.7 0.000). No differences were between two groups both systolic diastolic parameters echocardiography. Conclusion: These findings suggest an imbalance toward relative predominance parasympathetic tone, as already reported adult COVID. Further needed clarify clinical significance demonstrate its pathophysiological mechanism COVID, paving way effective therapeutic preventive strategies. What Known: • Long Covid children described globally, but mostly collecting temporal evolution symptoms. New: Cardiac tone children, adults.

Язык: Английский

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Mechanisms underlying exercise intolerance in long COVID: An accumulation of multisystem dysfunction

Physiological Reports, Год журнала: 2024, Номер 12(3)

Опубликована: Фев. 1, 2024

Abstract The pathogenesis of exercise intolerance and persistent fatigue which can follow an infection with the SARS‐CoV‐2 virus (“long COVID”) is not fully understood. Cases were recruited from a long COVID clinic ( N = 32; 44 ± 12 years; 10 (31%) men), age‐/sex‐matched healthy controls (HC) 19; 40 13 6 (32%) men) University College London staff students. We assessed performance, lung cardiac function, vascular health, skeletal muscle oxidative capacity, autonomic nervous system (ANS) function. Key outcome measures for each physiological compared between groups using potential means (95% confidence intervals) adjusted confounders. Long participant outcomes to normative values. When HC, cases exhibited reduced oxygen uptake efficiency slope (1847 (1679, 2016) vs. 2176 (1978, 2373) mL/min, p 0.002) anaerobic threshold (13.2 (12.2, 14.3) 15.6 (14.4, 17.2) mL/kg/min, < 0.001), lower measured near infrared spectroscopy τ : 38.7 (31.9, 45.6) 24.6 (19.1, 30.1) s, 0.001). In cases, ANS fell below normal limits in 39%. associated performance capacity absence evidence microvascular dysfunction, suggesting mitochondrial pathology. There was attendant dysregulation significant proportion. These multisystem factors might contribute impaired tolerance sufferers.

Язык: Английский

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Long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months

Annals of Medicine, Год журнала: 2025, Номер 57(1)

Опубликована: Янв. 16, 2025

The COVID-19 pandemic, caused by SARS-CoV-2, has had profound global impacts since its emergence in late 2019. Whilst acute symptoms are well-documented, increasing evidence suggests long-term consequences extending beyond the phase. This study aimed to investigate cognitive and autonomic effects of young adults. We conducted a cross-sectional comparing adults with history (n = 34) matched controls 34). Cognitive function was assessed using Sternberg Task, Stroop Go/No-Go Task (GNG). Autonomic evaluated heart rate variability (HRV) parameters. average time interval between infection testing 28.2 months. group showed significantly increased reaction 2-item absent condition (p 0.044) errors 4-item present 0.012) neutral response 0.028) normalized for completing task 0.022) Task. No significant differences were found GNG HRV parameters did not differ groups, although trends toward higher overall observed group. Young who approximately 28 months ago show minimal impact on regulation. However, subtle inefficiencies persist, particularly working memory executive tasks. These findings suggest generally favorable prognosis following mild moderate but highlight need further investigation into persistent effects.

Язык: Английский

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Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (Long Covid), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

Qeios, Год журнала: 2024, Номер unknown

Опубликована: Апрель 9, 2024

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies (AAs) related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role these on invading Candida hyphae explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens (epitopes), suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.

Язык: Английский

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Physical impairments in individuals with Long COVID

Frontiers in Sports and Active Living, Год журнала: 2025, Номер 7

Опубликована: Янв. 30, 2025

Objective The primary objective was to compare the physical capacities of individuals with Long COVID [Long group (LCG)] those who had COVID-19 but did not develop persistent symptoms [short (SCG)], and without a history [control (CG)]. secondary objectives were provide comprehensive profile sociodemographic COVID, considering factors such as sex, gender, hospitalization, time since onset, comorbidities, b) identify self-reported clinical measures explaining health-related quality life (HRQoL) in COVID. Methods A total 120 adults included each groups. Participants completed assessments covering HRQoL, pain, sleep, fatigue. Physical handgrip strength (HGS), Short Performance Battery (SPPB), 6-minute-walk-test (6MWT), perceived exertion during 6MWT (Modified-Borg Scale), daily step count 7-day period. Results Mean age (mean [SD]) for LCG, SCG, CG 44.2 [11.2], 42.1 [16.4], 46[15.9], respectively. LCG showed significantly higher fatigue, along lower HRQoL sleep compared other HGS, SPPB, performance also while higher. Finally, number steps per day LCG. Higher prevalence obesity comorbidities identified among hospitalized after COVID-19. Fatigue, Step variables ( R 2: 0.58; F = 35.9). Conclusion individuals, on average 329 [146] days post-infection, experience enduring challenges, significant implications their overall well-being.

Язык: Английский

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Long-Term Effects of COVID-19 on Cardiovascular System and the Risk Markers: A Systematic Review

SN Comprehensive Clinical Medicine, Год журнала: 2025, Номер 7(1)

Опубликована: Фев. 22, 2025

Язык: Английский

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Objective Detection of Chronic Infection-Acquired Physiological Changes via Wearables: Potential Implications for Long COVID

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 14, 2025

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can lead to post-acute sequelae of SARS-CoV-2 (PASC), or Long COVID, a chronic multisystemic condition with diverse symptoms and no objective diagnostic test. In this study, we developed data-driven method objectively detect persistent physiological changes post-COVID-19 using wearable device data. We analyzed data from 663 symptomatic COVID-19-positive cases 2,513 asymptomatic COVID-19-negative controls. Our identified alterations in 9.4% individuals, aligning previous COVID prevalence estimates. Additionally, vaccination reduced the risk these by ~ 40%. Affected individuals exhibited elevated resting heart rates rate variability. findings highlight potential technology identifying monitoring post-infection, offering scalable tool for assessment. This approach could enhance clinical evaluation personalized management cases.

Язык: Английский

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Post-coronavirus Disease 2019 (COVID-19) Cardiovascular Manifestations: A Systematic Review of Long-Term Risks and Outcomes

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Апрель 27, 2025

Язык: Английский

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Sex-specific differences of cardiopulmonary fitness and pulmonary function in exercise-based rehabilitation of patients with long-term post-COVID-19 syndrome

BMC Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 8, 2024

Post-COVID-19 Syndrome (PCS) entails a spectrum of symptoms, including fatigue, reduced physical performance, dyspnea, cognitive impairment, and psychological distress. Given the effectiveness exercise-based rehabilitation for PCS, this study examined efficacy PCS patients, focusing on sex-specific differences.

Язык: Английский

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