An antioxidant potential analysis of herbal silver nanoparticles synthesized from methanolic leaf extract of Cassia siamea DOI Open Access
Pratap Chand Mali, Neha Bharti,

Prity Yadav

и другие.

IP International Journal of Comprehensive and Advanced Pharmacology, Год журнала: 2024, Номер 9(4), С. 275 - 283

Опубликована: Ноя. 15, 2024

ynthesis and evaluation of in vitro antioxidant potential silver nanoparticles (AgNPs) made from methanolic leaf extract Cassia siamea, To develop a herbal, potential, cost-effective source antioxidative agents. Herbal matter have been good nutrition agents the ages, to fulfil requirements one by its natural phytoconstituents. Present study compiles the, green synthesis AgNPs using C. siamea. Synthesized were characterized used for detection their potential. The activity was analysed through DPPH FRAP assays. While is known, use siamea this purpose relatively underexplored, making significant contribution field nanotechnology antioxidants. findings highlight plant-mediated future applications biomedicine, particularly as natural, eco-friendly collection identification plant done University Campus. several techniques UV-Vis spectrophotometry, FTIR, XRD, particle size Zeta analysis, SEM, confirming formation stable AgNPs. synthesized evaluated assays, with ascorbic acid serving reference standard. By current can be concluded that after successful characterization AgNPs, Assay demonstrated had concentration-dependent % scavenging action, considerable radical inhibition at all examined levels, but they are lower than acid. Similarly, assay reducing power which increased concentration. IC values obtained both assays indicate possess substantial activity. bioactive chemicals play an important role nanoparticle stability. These suggest green-synthesized exhibit them promising candidates biomedicine nanotechnology. This contributes growing body research on such

Язык: Английский

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review DOI Creative Commons
Gayathri Unnikrishnan, Anjumol Joy,

M. Megha

и другие.

Discover Nano, Год журнала: 2023, Номер 18(1)

Опубликована: Дек. 19, 2023

The nanosystems for delivering drugs which have evolved with time, are being designed greater drug efficiency and lesser side-effects, also complemented by the advancement of numerous innovative materials. In comparison to organic nanoparticles, inorganic nanoparticles stable, a wide range physicochemical, mechanical, magnetic, optical characteristics, capability get modified using some ligands enrich their attraction towards molecules at target site, makes them appealing bio-imaging delivery applications. One strong benefits nanoparticles-drug conjugate is possibility affected cells locally, thus reducing side-effects like cytotoxicity, facilitating higher efficacy therapeutic drug. This review features direct indirect effects such gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, CeO2 in developing effective carrier systems. article has remarked peculiarities these nanoparticle-based systems pulmonary, ocular, wound healing, antibacterial deliveries as well across Blood-Brain-Barrier (BBB) acting agents cancer theranostics. Additionally, sheds light on plausible modifications that can be carried out from researcher's perspective, could open new pathway.

Язык: Английский

Процитировано

50
Nanotechnology for Healthcare: Plant-Derived Nanoparticles in Disease Treatment and Regenerative Medicine DOI Creative Commons
Arun Karnwal,

Amar Yasser Jassim,

Ameer A. Mohammed

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1711 - 1711

Опубликована: Дек. 18, 2024

Nanotechnology has revolutionised biomedical research, offering innovative healthcare solutions. Plant-based nanotechnology is emerging as a sustainable alternative, minimising environmental impacts and enhancing therapeutic effectiveness. This paper explores the potential of plant-derived nanoparticles (PNPs) in medicine, highlighting their biocompatibility, multifunctionality, eco-friendliness. PNPs, synthesised through green methods, have demonstrated promising applications drug delivery, cancer therapy, antimicrobial treatments, tissue regeneration. Their unique properties, such high surface area bioactive components, enable improved targeting, controlled release, reducing side effects treatment efficacy. Additionally, compounds’ inherent antioxidant retained within platinum (PNPs), present opportunities for combating resistance promoting wound healing. Despite potential, challenges remain standardising PNP synthesis, ensuring consistency, scaling up production industrial applications. review emphasises need further research on toxicity, regulatory frameworks to fully harness capabilities clinical commercial represents promising, greener alternative advancing solutions, aligning with global sustainability goals.

Язык: Английский

Процитировано

7
Uptake, Translocation, Toxicity, and Impact of Nanoparticles on Plant Physiological Processes DOI Creative Commons
M. Djanaguiraman, Anbazhagan Veerappan, Om Parkash Dhankher

и другие.

Plants, Год журнала: 2024, Номер 13(22), С. 3137 - 3137

Опубликована: Ноя. 7, 2024

The application of nanotechnology in agriculture has increased rapidly. However, the fate and effects various nanoparticles on soil, plants, humans are not fully understood. Reports indicate that exhibit positive negative impacts biota due to their size, surface property, concentration within system, species or cell type under test. In translocated either by apoplast symplast pathway both. Also, it is clear whether entering plant system remain as biotransformed into ionic forms other organic compounds. Controversial results toxicity nanomaterials available. general, nanomaterial was exerted producing reactive oxygen species, leading damage denaturation biomolecules. intensity cyto- geno-toxicity depends physical chemical properties nanoparticles. Based literature survey, observed growth, photosynthesis, primary secondary metabolism plants both negative; response these processes nanoparticle associated with nanoparticle, tissue, crop stage growth. Future studies should focus addressing key knowledge gaps understanding responses at all levels through global transcriptome, proteome, metabolome assays evaluating field conditions realistic exposure concentrations determine level entry food chain assess impact ecosystem.

Язык: Английский

Процитировано

6
Pharmacokinetics and toxicity of inorganic nanoparticles and the physicochemical properties/factors affecting them DOI Creative Commons
Ranim Saker, Géza Regdon, Tamás Sovány

и другие.

Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 99, С. 105979 - 105979

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

5
Synthesis of Silver Nanoparticles Using Extracts from Different Parts of the Paullinia cupana Kunth Plant: Characterization and In Vitro Antimicrobial Activity DOI Creative Commons
Alan Kelbis Oliveira Lima, Lucas Marcelino dos Santos Souza, Guilherme Fonseca Reis

и другие.

Pharmaceuticals, Год журнала: 2024, Номер 17(7), С. 869 - 869

Опубликована: Июль 2, 2024

The green synthesis of silver nanoparticles (AgNPs) can be developed using safe and environmentally friendly routes, replace potentially toxic chemical methods, increase the scale production. This study aimed to synthesize AgNPs from aqueous extracts guarana (Paullinia cupana) leaves flowers, collected in different seasons year, as a source active biomolecules capable reducing ions (Ag+) promoting stabilization colloidal (Ag0). plant were characterized regarding their metabolic composition by liquid chromatography coupled high-resolution mass spectrometry (UHPLC-HRMS/MS), phenolic compound content, antioxidant potential against free radicals. synthesized UV/Vis spectrophotometry, dynamic light scattering (DLS), nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), scanning energy-dispersive X-ray (EDX). results demonstrated that characterization indicated presence secondary metabolites many classes compounds studied studied, but alkaloids flavonoids predominant, which are widely recognized for capabilities. It was possible notice subtle changes properties nanostructures depending on parameters such seasonality part used, with showing surface plasmon resonance bands between 410 420 nm leaf extract 440 460 when prepared flower extract. Overall, average hydrodynamic diameters similar among samples (61.98 101.6 nm). Polydispersity index remained range 0.2 0.4, indicating stability did not change storage time. Zeta above −30 mV after one month analysis, is adequate biological applications. TEM images showed 40.72 48.85 particles morphologies. EDX content weight 24.06 28.81%. exhibited antimicrobial efficacy various pathogenic microorganisms clinical environmental interest, MIC values 2.12 21.25 µg/mL, close those described MBC values. Therefore, our revealed use native species Brazilian biodiversity combined nanotechnology produce agents.

Язык: Английский

Процитировано

4
Antifungal efficacy of Citrusfusion mediated silver nanoparticles in Candida species DOI Creative Commons

A. Harine,

S. Ranjani,

S. Hemalatha

и другие.

BMC Biotechnology, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 20, 2025

Candida species are commensal fungi that can become opportunistic pathogens under specific host and environmental conditions. The emergence of multidrug-resistant strains poses a significant challenge. Nanotechnology represents cutting-edge field offering precise targeted delivery systems for combating fungal infections, leveraging the unique properties plant-derived bioactive compounds. This investigation employed biogenic approach utilizing polyherbal leaf extracts from Citrus limon medica, known their abundant Citral content. sp. were used to synthesize Citrusfusion silver nanoparticles (CitAgNPs) through green synthesis method. Characterization CitAgNPs was carried out using advanced analytical methods ensuring quality, uniformity, size, charge. synthesized exhibited non toxic effect when tested on Vigna radiata Danio rerio, highlighting potential sustainability safe therapeutic use. Antifungal assays demonstrated potent efficacy in various strains, with low MIC MFC. remarkable biofilm inhibition capabilities elucidated mechanisms action species, surpassing performance fluconazole. study underscores immense nanotechnology-driven approaches harnessing extract synthesizing highly effective antifungal nanoparticles. fusion compounds presents sustainable strategy addressing escalating challenge azole-resistant infections. research outcomes suggest have promising applications inhibiting biofilms, solutions infections caused by diaper rashes onychomycosis, providing alternatives therapies.

Язык: Английский

Процитировано

0
Synthesis and Antioxidant Applications of Silver Oxide Nanoparticles via Kniphofia foliosa Extract DOI
Semagn Mekonnen Abate, Sisay Awoke Endalew,

Belete Tesfaw Abebaw

и другие.

Next research., Год журнала: 2025, Номер unknown, С. 100239 - 100239

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Biosynthesis of silver nanoparticles by Talaromyces funiculosus for therapeutic applications and safety evaluation DOI Creative Commons

Bahig A. El deeb,

Gerges G. Faheem,

Mahmoud S. Bakhit

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 21, 2025

Abstract The study investigated the capacity of endophytic fungus Talaromyces funiculosus to biosynthesize extracellular AgNPs and assess their safety. was identified through morphological phylogenetic analyses. biosynthesized were spherical crystalline, stable (6 months), mono-dispersed (PDI: 0.007), exhibiting SPR at 422.5 nm, average diameter 34.32 Zeta potential -18.41 mV. optimal biosynthesis conditions are 1 mM AgNO 3 , 5 g biomass, pH 5.5, a reaction temperature 60 °C. Escherichia coli (bacterial strains) Candida tropicalis (yeast exhibited highest susceptibility with inhibition zones 26.3 mm 22.3 mm, respectively, 50 µg/mL AgNPs, MICs 3.7 6.3 µg/mL, respectively. cytotoxicity IC values 48.11 ppm for HEK-293 35.88 Hep-G2 cells, showing selective toxicity toward cancer cells. They demonstrated antioxidant activity by increasing GSH (10.29 14.76 mmol/g) reducing MDA (40.57 26.28 nmol/ml) ppm. also enhanced IL-10 production (96.47 177.0 pg/mL) reduced TNF-α levels (55.77 41.06 pg/mL), indicating anti-inflammatory properties. These results support safe use low-dose however, further studies needed evaluate clinical uses.

Язык: Английский

Процитировано

0
Biomimetic green synthesis of ZnO nanoflowers using α-amylase: from antimicrobial to toxicological evaluation DOI Creative Commons
Jahirul Ahmed Mazumder, Atika Ahmad,

Juned Ali

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Июль 17, 2024

Biologically mediated synthesis of nanomaterials has emerged as an ecologically benign and biocompatible approach. Our study explores enzymatic synthesis, utilizing α-amylase to synthesize ZnO nanoflowers (ZnO-NFs). X-ray diffraction energy-dispersive spectroscopy revealed crystal structure elemental composition. Dynamic light scattering analysis indicates that ZnO-NFs possess a size 101 nm. Transmission electron microscopy showed star-shaped morphology with petal-like structures. exhibit potent photocatalytic properties, degrading 90% eosin, 87% methylene blue, 81% reactive red dyes under UV light, kinetics fitting the Langmuir–Hinshelwood pseudo-first-order rate law. The impact pH interfering substances on dye degradation was explored. display efficient bacteriocidal activity against different Gram-positive negative strains, antibiofilm potential (especially P. aeruginosa), hemocompatibility up 600 ppm, suggesting versatile in healthcare environmental remediation applications.

Язык: Английский

Процитировано

3
Use of Aloe Vera Gel as Media to Assess Antimicrobial Activity and Development of Antimicrobial Nanocomposites DOI Open Access
Erwan Rauwel, Geeta Arya, Kristi Praakle

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5599 - 5599

Опубликована: Май 21, 2024

Antimicrobial resistance is a menace to public health on global scale. In this regard, nanomaterials exhibiting antimicrobial properties represent promising solution. Both metal and oxide are suitable candidates, even though their mechanisms of action vary. Multiple can occur simultaneously or independently; includes either direct contact with the pathogens, nanomaterial uptake, oxidative stress, ion release, any combinations. However, due specific more particularly fast settling, existing methods study nanoparticles have not been specifically adapted in some cases. The development methodologies that assess metallic accurately necessary. A cost-effective methodology straightforward set-up enables easy quick assessment high accuracy has developed. also capable confirming whether killing mechanism involves ionic diffusion. Finally, Aloe Vera gel showed good for use as medium ointment.

Язык: Английский

Процитировано

2