Reshaping the healthcare world by AI-integrated wearable sensors following COVID-19

Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159478 - 159478

Опубликована: Янв. 11, 2025

Язык: Английский

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Staunch the Age Related Decline into Dementia, Cancer, Autoimmunity (Long Covid), Obesity, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

Qeios, Год журнала: 2024, Номер unknown

Опубликована: Апрель 9, 2024

“All diseases originate in the gut.” Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, can alter tryptophan metabolism (ATM) increase kynurenine to ratio (KTR) with release proinflammatory cytokines, predominantly TNF-α, IL-6, IL-1β. These also characterize chronic inflammation, oxidative stress, multitude diseases. Also proposed is gut-lung dysbiosis concept consequent degradation ACE2 (richest lungs gut). Leaky (and lung) induced autoantibodies (AAs) related G-protein coupled receptors (GPCRs) combination increased Ang II further potentiate stress. The underappreciated pathogenic role these on invading Candida hyphae explored. efficacy fecal transplantation (FMT) treating dementia, cancer, autoimmunity supports plausibility success “FMT-lite”. This triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, oppose entry GPCR antigens (epitopes), suppress inflammatory cytokine triad, balance IFN-γ TGF-β, depress KTR, elevate HRV, extend lifespan its quality.

Язык: Английский

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Heart rate variability modulation through slow paced breathing in Healthcare workers with Long-COVID: a case-control study

The American Journal of Medicine, Год журнала: 2024, Номер unknown

Опубликована: Май 1, 2024

Язык: Английский

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Cholesterol, triglycerides, HDL, and nitric oxide as determinants of resting heart rate variability in non-hospitalized mild post-COVID individuals: a cross-sectional study

BMC Cardiovascular Disorders, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 31, 2025

Abstract Background The association between plasma lipids, nitric oxide (NO) and cardiovascular risk has been well documented in the literature, however, these outcomes heart rate variability (HRV) COVID-19 remains incipient as there is no scientific evidence that investigated this outcome. Objective Investigate whether metabolic may be associated with cardiac autonomic behavior arising from short-term HRV variables non-hospitalized mild post-COVID individuals. Methods This a cross-sectional study. Individuals of both sexes, aged ≥ 18 years, who tested positive for SARS-CoV-2 according to RT-PCR test, without need hospitalization, were included. was collected supine position at least 10 min later analysis Kubios software. Metabolic [high density lipoprotein (HDL) (mg/dL), cholesterol triglycerides (mg/dL) NO (µmol/L)] through blood sample. Results Seventy-three individuals included (post-COVID = 32; control 41). worse group when compared ( p < 0.05). Cholesterol, HDL, showed significant correlations indices. Regression models indicated triglycerides, NO, explain up 30.3% variations certain indices, suggesting an impact on modulation. Conclusion There relationship COVID-19. are 16.6% 30.30% resting Clinical trial number Not applicable.

Язык: Английский

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Preliminary Evaluation of a Mindfulness Intervention Program in Women with Long COVID Dysautonomia Symptoms

Brain Behavior & Immunity - Health, Год журнала: 2025, Номер unknown, С. 100963 - 100963

Опубликована: Фев. 1, 2025

The symptom burden for patients with Long COVID-associated dysautonomia is high, yet there are currently no effective treatments. Mindfulness programs reduce psychological and physical symptoms as well inflammatory gene expression in a variety of medical conditions. study aim was to evaluate the effect six-week mindfulness program women COVID symptoms. Using single arm, pre- posttest design, aged 18-54 years orthostatic intolerance suggestive were recruited from center. Participants attended standardized, six-week, virtual program. An active stand test 6-min walk (6MWT) performed at baseline post-intervention. Self-reported measures mental health collected baseline, post-intervention 4 week follow up included composite autonomic score (COMPASS-31), perceived stress (PSS), anxiety (GAD7), depression (PHQ8), COVID-19 event specific distress (IES-R), fatigue (FSI), sleep (ISI), well-being (MHC-SF), resilience (CD-RISC 10), quality life (SF-20). effects on conserved transcriptional response adversity (CTRA) examined by next-generation sequencing dried whole blood samples. Twenty participants enrolled mean age 39.9 (range 21-52 years). No significant changes observed or 6MWT. A reduction insomnia severity (ISI: 16.6 vs. 13.6; p = 0.001) post-intervention, but scores reverted toward levels 4-week follow-up. improvements seen symptoms, anxiety, stress, depression, well-being, related distress. Pro-inflammatory CTRA decreased significantly pre-to (p 0.004). Declines most among those 3 positive events 0.01), followed 2 0.04) 1 0.05). did not vary function recent illness, hospitalization, demographic characteristics, general history. virtual, may improve dysautonomia. While objective improvement observed, our findings suggest favorable intervention antiviral biology decrease expression. Nonetheless, this population very more attention needed provide multi-modal clinical therapies population.

Язык: Английский

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Reduced autonomic function in patients with long-COVID-19 syndrome is mediated by cardiorespiratory fitness

Current Problems in Cardiology, Год журнала: 2024, Номер 49(9), С. 102732 - 102732

Опубликована: Июль 1, 2024

Long-COVID-19 syndrome (LCS) exhibits neurological problems such as peripheral neuropathy and autonomic nervous system (ANS) dysfunction. Exercise intolerance and, consequently, low cardiorespiratory fitness (CRF) are some of the most common symptoms LCS. We describe a series individuals exhibiting LCS compared to control group posit that this condition may be related exercise capacity-mediated disruption ANS resulting particularly in intolerance.

Язык: Английский

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Postacute Sequelae of COVID (PASC or Long COVID): An Evidenced-Based Approach

Open Forum Infectious Diseases, Год журнала: 2024, Номер 11(9)

Опубликована: Авг. 27, 2024

Abstract While the acute manifestations of infectious diseases are well known, in some individuals, symptoms can either persist or appear after period. Postviral fatigue syndromes recognized with other viral infections and described coronavirus disease 2019 (COVID-19). We have a growing number individuals that for weeks, months, years. Here, we share evidence regarding abnormalities associated postacute sequelae COVID-19 (PASC) therapeutics. describe physiological biochemical seen reporting PASC. several evidence-based interventions to offer patients. It is expected this understanding mechanisms driving PASC benefits certain therapeutics may not only lead better outcomes those but also potential treating postinfectious sequelae.

Язык: Английский

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Evidence-Based Clinical Utility of Heart Rate Variability Across Populations, Including Long COVID

Cardiopulmonary Physical Therapy Journal, Год журнала: 2024, Номер unknown

Опубликована: Дек. 3, 2024

Purpose: Heart rate variability (HRV) has been used for decades as a tool measuring systemic health through the autonomic nervous system (ANS). The purpose of this paper was to examine literature on HRV and investigate its use in long COVID (LC) population. Summary Key Points: Measurement devices vary significantly their validity reliability when compared with gold standard electrocardiogram (ECG). Wrist hand typically demonstrate diminished capturing signal, while chest strap often exhibit high validity. Lack transparency third-party software clean analyze data makes assessment accuracy problematic. This is particular concern single beat miscalculations can result dissimilar output. conditions under which are collected, such natural or paced breathing, activity intensity, patient position, dramatically affect readings. While some individual metrics have consistently shown reflect certain components ANS, high-frequency power measure parasympathetic function, meaning other less clear. Recommendations Clinical Practice: be an extraordinarily valuable function. However, it recommended that clinicians judicious interpretation HRV, considering inconsistencies presentation. particularly true LC, where varies greatly. In all populations, should consider using valid assess trends values over time, along consideration unique physical conditions.

Язык: Английский

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Staunch the Age Related Decline into Depression, Dementia, Diabetes, Obesity, Cancer, Long Covid, and Other Diseases with a Prebiotic, Probiotic, Postbiotic Triple Play

Опубликована: Янв. 30, 2024

&ldquo;All diseases originate in the gut.&rdquo; Hippocrates (400 BC) A healthy gut microbiome via gut-brain-axis (GBA) elevates heart rate variability (HRV), a general measure of health and well-being. dysbiotic microbiome, low biodiversity butyrate producers, triggers altered tryptophan metabolism release proinflammatory cytokines, predominantly TNF-&alpha;, IL-6, IL-1&beta;, that also characterize chronic inflammation, oxidative stress, multitude diseases, all exhibiting HRV. Gut dysbiosis upregulates IFN-&gamma; with it IDO (indoleamine 2,3 dioxygenase). Tryptophan pivots from serotonin synthesis to kynurenine, increasing kynurenine ratio (KTR). An elevated KTR is positively linked neurodegenerative autoimmune negatively Elevated activity not only enzymatic but an intracellular signal transducer potentiated by TGF-&beta;. This cytokine primary determinant TME. The triple play prebiotic (d-mannose), probiotic (bifidobacteria lactobacilli), postbiotic (butyrate) might improve intestinal barrier integrity, suppress inflammatory triad, balance TGF-&beta;, depress KTR, elevate HRV, extend lifespan.

Язык: Английский

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Impact of COVID-19 on heart rate variability in post-COVID individuals compared to a control group

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Дек. 28, 2024

Abstract This study investigated the impact of mild COVID-19 on HRV in groups stratified by time after infection and to compare a healthy group same age without previous virus need hospitalization. is cross-sectional study. We divided sample into four groups: control (CG) ( n = 31), 1 (G1): ≤6 weeks 34), 2 (G2): 2–6 months 30), 3 (G3): 7–12 35) infection. For analysis, we used indices linear (time frequency domain) non-linear analysis. comparisons between groups, ANOVA one way test or Kruskal–Wallis was according data distribution. The effect size calculated based Cohen’s d η . Simple multiple regressions were performed investigate interaction clinical outcomes parameters. A total 130 individuals included. Groups G1 G2 showed less parasympathetic modulation when compared CG p < 0.05), while G3 an increase 0.05). Moderate large sizes found Cohen regression models identified duration as significant predictors for RMSSD (adjusted R 0.227) SD1 0.242), SDNN 0.213). BMI, hypertension, dyslipidemia non-significant all models. HF (n.u.), consistently significant, with stress emerging predictor Model 0.143). recovery since diagnosis influences from HRV, suggesting transient disease autonomic nervous system.

Язык: Английский

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