Bioconversion of Fe3O4 Nanoparticles by Probiotics

Pharmaceuticals, Год журнала: 2025, Номер 18(4), С. 542 - 542

Опубликована: Апрель 8, 2025

Background/Objectives: Iron deficiency anemia remains a primary global health concern, affecting millions worldwide. Despite the widespread availability of iron supplements, their efficacy is often hindered by poor bioavailability and adverse gastrointestinal effects. This study explores potential probiotics to enhance Fe3O4 NPs through probiotic-mediated mechanisms. Methods: Lactobacillus fermentum, rhamnosus, plantarum were utilized investigate interactions with NPs, synthesized via co-precipitation characterized using transmission electron microscopy, scanning Fourier transform infrared spectroscopy, X-ray diffraction. Results: The results indicated that adhere nanoparticle surface, L. fermentum exhibiting highest adhesion internalization capacity, leading significant increase in 4-hydroxyphenylacetic acid (4-HPLA) production (11.73 ± 0.09 mg/mL at 24 h, p < 0.05). Spectroscopic analyses further revealed probiotic metabolism facilitates oxidation Fe2O3. Additionally, nanoparticle-treated cultures demonstrated enhanced bacterial viability metabolic activity, highlighting synergistic effect between nanoparticles. Conclusions: These findings provide compelling evidence for probiotic-assisted supplementation as promising strategy while mitigating side effects conventional supplements.

Язык: Английский

Investigation of impact of siderophore and process variables on production of iron enriched Saccharomyces boulardii by Plackett–Burman design

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 1, 2024

Язык: Английский