Dietary restriction and life-history trade-offs: insights into mTOR pathway regulation and reproductive investment in Japanese quail

Journal of Experimental Biology, Год журнала: 2024, Номер 227(8)

Опубликована: Апрель 2, 2024

Resources are needed for growth, reproduction and survival, organisms must trade off limited resources among competing processes. Nutritional availability in is sensed monitored by nutrient-sensing pathways that can trigger physiological changes or alter gene expression. Previous studies have proposed one such signalling pathway, the mechanistic target of rapamycin (mTOR), underpins a form adaptive plasticity when individuals encounter constraints their energy budget. Despite fundamental importance this process evolutionary biology, how nutritional limitation regulated through expression genes governing pathway its consequential effects on fitness remain understudied, particularly birds. We used dietary restriction to simulate resource depletion examined body mass, Japanese quails (Coturnix japonica). Quails were subjected feeding at 20%, 30% 40% levels ad libitum 2 weeks. All restricted groups exhibited reduced whereas reductions number mass eggs observed only under more severe restrictions. Additionally, led decreased mTOR insulin-like growth factor 1 (IGF1), ribosomal protein S6 kinase (RPS6K1) autophagy-related (ATG9A ATG5) upregulated. The pattern which responded was similar mass. Regardless treatment, proportionally higher reproductive investment associated with individual variation These findings reveal connection between intake related pathway.

Язык: Английский

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Maternal Iron Deficiency Modulates Antioxidant Status and Longevity in a Sex-Dependent Manner in Drosophila melanogaster

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Background: Maternal iron deficiency (ID) disrupts both maternal and offspring health by impairing status antioxidant defenses. This study examines the intergenerational effects of ID rapamycin intervention on Drosophila melanogaster. Rapamycin is known for promoting autophagy, longevity, activity. Method: Female flies (F0) were subjected to an iron-deficient diet 14 days, followed a 30-day with either normal or rapamycin-treated diet. After chelation, some F0 females crossed males produce F1 offspring. Physiological, biochemical, gene expression changes assessed in after days chelation 30 interventions. Post-eclosion evaluations conducted flies, along 60-day survival generations. Result: In females, significantly reduced (p < 0.0001) body weight, levels, enzyme while increasing GSH levels. Gene showed significant 0.05) storage (Fer1HCH), autophagy (ATG1), telomere-related genes (dHeT-A, dTahre, dTart). A partially restored levels survival, improved antioxidants but had mixed expression. male/female exhibited reduced/increased respectively, also increased median weight female their survival. Conclusion: has lasting effects, diets restoring enhances defenses reduces particularly females.

Язык: Английский

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Sex‐specific effects of dietary restriction on physiological variables in Japanese quails

Ecology and Evolution, Год журнала: 2024, Номер 14(5)

Опубликована: Май 1, 2024

Abstract Nutritional limitation is a common phenomenon in nature that leads to trade‐offs among processes competing for limited resources. These are mediated by changes physiological traits such as growth factors and circulating lipids. However, studies addressing the sex‐specific effect of nutritional deficiency on these variables birds. We used dietary restriction mimic depletion resources various degrees investigated effects levels insulin‐like factor 1 (IGF‐1) triglycerides Japanese quails ( Coturnix japonica ) subjected ad libitum, 20%, 30% or 40% their daily requirement, 2 weeks. also explored association both with body mass egg production. While showed no IGF‐1, this hormone exhibited marked sexual difference, females having 64.7% higher IGF‐1 than males. Dietary significantly reduced plasma triglyceride sexes. Females more six‐fold Triglyceride were positively associated while not Overall, our findings revealed expression under conditions, which coincide size.

Язык: Английский

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Conservation Genetics and Breeding using Molecular Genetic Markers in Japanese Quail (Coturnix japonica)

Frontiers in Bioscience-Scholar, Год журнала: 2024, Номер 16(4)

Опубликована: Дек. 20, 2024

The Japanese quail (

Язык: Английский

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Sex‐dependent molecular landscape of Alzheimer's disease revealed by large‐scale single‐cell transcriptomics

Alzheimer s & Dementia, Год журнала: 2024, Номер unknown

Опубликована: Дек. 31, 2024

Alzheimer's disease (AD) shows significant sex differences in prevalence and clinical manifestations, but the underlying molecular mechanisms remain unclear.

Язык: Английский

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