Sex‐specific effects of dietary restriction on physiological variables in Japanese quails DOI Creative Commons
Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus

и другие.

Ecology and Evolution, Год журнала: 2024, Номер 14(5)

Опубликована: Май 1, 2024

Abstract Nutritional limitation is a common phenomenon in nature that leads to trade‐offs among processes competing for limited resources. These are mediated by changes physiological traits such as growth factors and circulating lipids. However, studies addressing the sex‐specific effect of nutritional deficiency on these variables birds. We used dietary restriction mimic depletion resources various degrees investigated effects levels insulin‐like factor 1 (IGF‐1) triglycerides Japanese quails ( Coturnix japonica ) subjected ad libitum, 20%, 30% or 40% their daily requirement, 2 weeks. also explored association both with body mass egg production. While showed no IGF‐1, this hormone exhibited marked sexual difference, females having 64.7% higher IGF‐1 than males. Dietary significantly reduced plasma triglyceride sexes. Females more six‐fold Triglyceride were positively associated while not Overall, our findings revealed expression under conditions, which coincide size.

Язык: Английский

Embryonic methionine triggers post-natal developmental programming in Japanese quail DOI Creative Commons
Sawadi F. Ndunguru, Gebrehaweria K. Reda, Brigitta Csernus

и другие.

Journal of Comparative Physiology B, Год журнала: 2024, Номер 194(2), С. 179 - 189

Опубликована: Март 23, 2024

Embryonic development is one of the most sensitive and critical stages when maternal effects may influence offspring's phenotype. In birds other oviparous species, embryonic confined to eggs, therefore females must deposit resources into eggs prepare offspring for prevailing post-natal conditions. However, mechanisms such phenotypic adjustments remain poorly understood. We simulated a nutritional transfer by injecting 1 mg L-methionine solution Japanese quail before onset incubation. The increase in early methionine concentration activated insulin/insulin-like signalling mechanistic target rapamycin (IIS/mTOR) pathways affected developmental trajectories. Chicks from methionine-supplemented had higher expression liver IGF1 mTOR genes at hatching but were similar size, increased growth became apparent only week later remained up three weeks. Circulating levels insulin-like factor-1 (IGF-1) ribosomal protein serine 6 kinase (RPS6K1), downstream effector, elevated weeks after hatching. These results show that specific cues have programming sequentially activating nutrient-sensing achieving transgenerational plasticity.

Язык: Английский

Процитировано

5
Dietary restriction reveals sex-specific expression of the mTOR pathway genes in Japanese quails DOI Creative Commons
Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Апрель 9, 2024

Limited resources affect an organism's physiology through the conserved metabolic pathway, mechanistic target of rapamycin (mTOR). Males and females often react differently to nutritional limitation, but whether it leads differential mTOR pathway expression remains unknown. Recently, we found that dietary restriction (DR) induced significant changes in genes female Japanese quails (Coturnix japonica). We simultaneously exposed 32 male either 20%, 30%, 40% or ad libitum feeding for 14 days determined six key liver investigate sex differences patterns. DR significantly reduced body mass, albeit effect was milder males compared females. observed sex-specific gene expression. downregulated more than males. Under moderate DR, ATG9A RPS6K1 expressions were increased Like females, mass correlated positively with IGF1, negatively RS6K1 expressions. Our findings highlight sexes may cope deficits emphasise importance considering sexual studies restriction.

Язык: Английский

Процитировано

5
ECR Spotlight – Gebrehaweria Reda DOI Creative Commons
Gebrehaweria K. Reda

Journal of Experimental Biology, Год журнала: 2024, Номер 227(8)

Опубликована: Апрель 15, 2024

ECR Spotlight is a series of interviews with early-career authors from selection papers published in Journal Experimental Biology and aims to promote not only the diversity researchers (ECRs) working experimental biology but also huge variety animals physiological systems that are essential for ‘comparative’ approach. Gebrehaweria Reda an author on ‘ Dietary restriction life-history trade-offs: insights into mTOR pathway regulation reproductive investment Japanese quails’, JEB. PhD student lab Levente Czeglédi Ádám Z. Lendvai at University Debrecen, Hungary, investigating molecular nutrition birds.

Язык: Английский

Процитировано

0
Sex‐specific effects of dietary restriction on physiological variables in Japanese quails DOI Creative Commons
Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus

и другие.

Ecology and Evolution, Год журнала: 2024, Номер 14(5)

Опубликована: Май 1, 2024

Abstract Nutritional limitation is a common phenomenon in nature that leads to trade‐offs among processes competing for limited resources. These are mediated by changes physiological traits such as growth factors and circulating lipids. However, studies addressing the sex‐specific effect of nutritional deficiency on these variables birds. We used dietary restriction mimic depletion resources various degrees investigated effects levels insulin‐like factor 1 (IGF‐1) triglycerides Japanese quails ( Coturnix japonica ) subjected ad libitum, 20%, 30% or 40% their daily requirement, 2 weeks. also explored association both with body mass egg production. While showed no IGF‐1, this hormone exhibited marked sexual difference, females having 64.7% higher IGF‐1 than males. Dietary significantly reduced plasma triglyceride sexes. Females more six‐fold Triglyceride were positively associated while not Overall, our findings revealed expression under conditions, which coincide size.

Язык: Английский

Процитировано

0